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Dokiran medicine has the main active ingredient is Fluconazole with a concentration of 50mg and other excipients in sufficient quantities. This is an antibiotic that is used to treat diseases caused by parasites, anti-infectives, antivirals and antifungals.
1. What is the drug Dokiran?
Dokiran medicine has the main active ingredient is Fluconazole with a concentration of 50mg and other excipients in sufficient quantities. This is an antibiotic that is used in the treatment of diseases caused by parasites, anti-infectives, antivirals and antifungals.
Dokiran medicine is made in the form of hard capsules, suitable for direct oral use. Packing is a box of 2 blisters and each blister contains 10 capsules. The active ingredient fluconazole works well against most strains of Candida, including late-stage fungal infections in people with AIDS who are resistant to other antifungal drugs such as Nystatin, Ketoconazole and Clotrimazol. Therefore, the main active ingredient Fluconazole is indicated for the following cases:
Treatment of meningococcal infections caused by Cryptococcus. Treatment of esophageal candidiasis in people with AIDS.
2. What disease does Dokiran treat?
Dokiran drug is indicated in the treatment of the following diseases:
Treatment of candidiasis in the vagina and vulva. Treatment of candidiasis of the mouth - pharynx, oesophagus, urinary tract, peritoneum and other serious systemic candidal infections such as blood candidiasis, lung, disseminated candidiasis. Treatment of meningitis caused by Cryptococcus neoformans. Treatment of fungal diseases caused by Blastomyces, Coccidioides immititis and Histoplasma. Prophylaxis: Prophylaxis of Candida infections in immunocompromised individuals, bone marrow transplant recipients undergoing chemotherapy or radiation therapy, cancer, or AIDS.
3. Usage and dosage of Dokiran
Dosage and duration of treatment depend on the type of fungus causing the disease, kidney function and individual response to Dokiran drug. When treating fungal diseases, this drug should be used continuously until clinical and laboratory manifestations show that the disease is completely cured. Inadequate treatment can cause the disease to recur and the condition to become more severe.
3.1. Treatment dose for people with HIV infection and cryptococcal meningitis: For people in this group, long-term maintenance therapy with Dokiran is required to prevent recurrence of the disease.
3.2. Therapeutic dose for infants: Children in the first 2 weeks after birth: dose 3-6 mg/kg/time; every 72 hours. Children from 2 to 4 weeks after birth: dose 3-6 mg/kg/time; every 48 hours. 3.3. Therapeutic dose for children: Prophylactic treatment: 3 mg/kg/day in superficial fungal infections and 6-12 mg/kg/day in systemic fungal infections. Treatment: dose 6 mg/kg/day. In cases of persistent disease, up to 12 mg/kg/24 hours may be required in 2 divided doses. Do not take more than 600 mg per day. 3.4. Dosage for adults: Candida infections:
Dosage for treatment of vulvovaginal candidiasis: Use a single dose of 1 tablet (150mg)/time/day. To prevent the risk of disease recurrence, the doctor will prescribe a dose of 1 tablet (150mg) / time / month for a period of 4 to 12 months. Dosage for treatment of oropharyngeal thrush: The recommended dose is 1 tablet (150mg)/time/day, for 1 to 2 weeks. Dosage for treatment of esophageal thrush: Take 1 tablet (150mg) once a day, for at least 3 consecutive weeks and for at least 2 more weeks until the symptoms are gone. Dosage for systemic fungal treatment: Take 3 tablets on the first day, take 1 tablet (150mg) in the following days, for at least 4 weeks and at least 2 more weeks until the symptoms are gone. . In case of meningitis caused by Cryptococcus: 3 tablets/time on the first day, 1-3 tablets/time/day in the following days, for at least 6 to 8 weeks after CSF culture until negative results. Dosage with HIV-infected people, in order to avoid recurrence, Difuzit should be used at a dose of 1 tablet / time / day for a long time. Dosage for prophylaxis of fungal infections: For the prevention of Candida infections in bone marrow transplant recipients, the recommended dose is 3 tablets (450mg)/time/day. 3.5. Dosage for patients with renal failure: Patients using a single dose to treat vulvovaginal candidiasis: no dose adjustment is required. People with kidney failure must take multiple doses of fluconazole, adjust the dose according to the doctor's prescription.
4. Undesirable effects of the drug Dokiran
During the use of Dokiran, you may experience some unwanted effects of the drug, specifically as follows:
Common adverse effects with ADR frequency > 1/100:
For the nervous system Menstrual: Headache, dizziness accompanied by dizziness. For the digestive system: Nausea, vomiting, abdominal pain, digestive disorders, diarrhea. Uncommon side effects with an ADR frequency of 1/1000:
For the liver: A transient increase in serum transaminase and bilirubin (from 1.5 to 3 times the upper limit of normal). For skin: Rash, itching on the skin. Rare side effects, specifically as follows:
For blood: Increased eosinophil index, anemia, decreased white blood cell count, decreased neutrophil count, decreased platelet count. For the liver: Elevated serum transaminase levels (8 times or more the upper limit of normal) and the drug must be discontinued. For the skin: Scaly skin (mainly in people with AIDS and cancer), Stevens-Johnson syndrome. Other undesirable effects: Fever, edema, pleural effusion, oliguria, hypotension, hypokalemia, anaphylactic reactions. However, it is very difficult to evaluate and determine the relationship between fluconazole active ingredient and unwanted effects, because Dokiran has been used for many patients with severe infections who have used many drugs simultaneously.
You need to actively inform the treating doctor of any unwanted effects encountered during the use of Dokiran.
5. Interactions of Dokiran
The active ingredient Fluconazole increases the plasma concentration of drugs such as sulfonylurea antidiabetic drugs (Tolbutamide, Glyburide, Glipizide), Phenytoin (medicine for epilepsy), Theophylline (medicine for asthma) , Astemizol (antihistamine), Coumarin anticoagulants (Warfarin), antivirals (Zidovudine), Cisaprid, Tacrolimus and Cyclosporin when used concurrently. Therefore, it is possible to increase the effects and toxicity of these drugs.Concomitant use of Fluconazole or Dokiran and Rifampicin may affect the pharmacokinetics of both drugs. Rifampicin reduces the absorption and half-life of the active substance Fluconazole, because the therapeutic dose of Fluconazole should be increased when used concomitantly.
There have been reports of interactions when concomitant use of drugs containing the active ingredient fluconazole with rifabutin or fluconazole with zidovudine in HIV-infected people.
6. Some notes when using Dokiran
6.1. Contraindications of Dokiran: People with hypersensitivity or hypersensitivity to Azol antifungals including Ketoconazole, Miconazole, and Clotrimazol or any of its ingredients.
6.2. Precautions for Dokiran: Caution should be exercised when using Dokiran for people with impaired liver or kidney function, cardiac arrhythmias, prolongation of the QT interval on the electrocardiogram. Effects of Dokiran on pregnancy: To date, there are no adequate studies on the use of drugs containing the active ingredient Fluconazole in pregnant women. Therefore, Dokiran should be used during pregnancy only when the potential benefit outweighs the potential risk to the fetus. Effects of Dokiran in lactation: Fluconazole is excreted in milk at concentrations similar to those in plasma, so its use is contraindicated in nursing mothers. Effects of Dokiran on the ability to operate machinery or drive: The drug may cause adverse effects such as headache, dizziness, so caution should be exercised when doing tasks that require high concentration such as driving. vehicles and operate machinery. Above is all information about Dokiran drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Dokiran medicine to treat diseases at home, because there may be unwanted side effects to health.
