Uses of Diphereline 3 75mg

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1. What is Diphereline 3 75mg?

Diphereline 3 75mg belongs to the ETC group of drugs, used to treat conditions such as prostate cancer, stage I - IV endometriosis, premature puberty in both boys and girls, female infertility. or preoperative treatment of uterine fibroids. Currently, Diphereline 3 75mg is manufactured by Ipsen Pharma Biotech - France with the dosage form of powder for suspension for injection, in which each box will include a vial of powder, a syringe, a tube of 2ml and 2 solvents. needle.
In a packet of Diphereline 3 powder 75mg contains the following ingredients:
Main active ingredient: Triptoreline 3.75mg. Other excipients: Polysorbate 80, Mannitol, D,L lactide Coglycolide Polymer, Sodium Carmellose, Mannitol and water for injection.

2. What are the effects of Diphereline 3 75mg?

2.1. Uses of Diphereline 3 75mg The main active ingredient Triptoreline in Diphereline 3 75mg acts as a synthetic Decapeptide similar to natural GnRH. This substance has the ability to inhibit gonadotropic secretion, thereby causing loss of function of the ovaries in women and testes in men.
According to research, Triptoreline acts directly on the gonads in the human body through its ability to reduce the sensitivity of peripheral receptors for GnRH. Besides, Triptoreline also works to create complete ovarian follicles, thereby effectively treating infertility in women.
2.2. Indications to use Diphereline 3 75mg Diphereline 3 75mg is often prescribed by doctors to treat the following cases:
Locally advanced or metastatic prostate cancer. The therapeutic effect of Diphereline 3 75mg will be higher if the patient has never used any hormone. Diphereline 3 75mg can be used alone or in combination with radiation therapy. Treatment of precocious puberty in boys before the age of ten and girls before the age of 8. Treatment of endometriosis in women stage I - IV. Diphereline 3 75mg for endometriosis patients should not be used for more than 6 months and should only be treated in 1 course. Treatment of infertility in women. Diphereline 3 75mg can be combined with gonadotropic hormones such as hCG, FSH and hMG in phase to help induce ovulation and embryo transfer (IVF). Preoperative treatment for uterine fibroids, for fibroids associated with anemia (hemoglobin concentration less than or equal to 8g/dl). Diphereline 3 75mg will be indicated to reduce the size of the tumor, making the process of laparoscopic or vaginal surgery easier and more convenient. The duration of treatment with Diphereline 3 75mg is usually limited to 3 months. 2.3. Contraindications to the use of Diphereline 3 75mg Do not use Diphereline 3 75mg for the following subjects without the doctor's instructions:
Contraindicated Diphereline 3 75mg for people who are sensitive or hypersensitive to the active ingredient Triptorelin, Dextran, Poly-(d, l lactide coglycolide) or any other excipients in the drug. Contraindicated in people with hypersensitivity to Gonadotrophin-releasing hormone (GnRH) or any other GnRH-like substance. Do not arbitrarily use Diphereline 3 75mg for pregnant or lactating women.

3. Dosage and how to use Diphereline 3 75mg

3.1. Recommended dosage of Diphereline 3 75mg Below is the dose of Diphereline 3 75mg as recommended by doctors for each specific patient:
Prostate cancer treatment dose:
Patients can choose to apply one of the following two regimens:
Inject 1 dose of Diphereline 0.1mg/day x 7 days under the skin, on day 8 inject a dose of Diphereline 3 75mg intramuscularly and repeat every 4 weeks. Intramuscular injection of Diphereline 3 75mg at baseline every 4 weeks. Dosage for treatment of precocious puberty:
Children under 20kg: Intramuscular 1/2 vial of Diphereline 3 75mg every 4 weeks (38 days), inject about half of the mixed drug. Children weighing 20 - 30 kg: Intramuscularly 2/3 vial of Diphereline 3 75mg per week, inject about 2/3 of the mixed drug. Children weighing more than 30 kg: Intramuscularly one vial of Diphereline 3 75mg every 4 weeks, ie inject the entire amount of mixed drug. Dose to treat endometriosis:
The patient will receive one vial of Diphereline 3 75mg every 4 weeks. The first injection should be given during the first 5 days of the menstrual cycle. The duration of endometriosis treatment with Diphereline 3 75mg will depend on the initial severity of the disease as well as the patient's clinical changes during treatment. As a rule, endometriosis can be treated with Diphereline 3 75mg for at least 4 months and not longer than 6 months. Diphereline 3 75mg should only be treated once.
Dose to treat female infertility:
On the 2nd day of the menstrual cycle, the patient will be injected intramuscularly 1 vial of Diphereline 3 75mg. After about 15 days of injecting Diphereline 3 75mg, the drug can be used in combination with gonadotropic hormones when the pituitary gland is suppressed and the blood estrogen hormone level is below 50pg/ml.
Treatment dose before surgery for uterine fibroids:
The patient will be injected intramuscularly with a vial of Diphereline 3 75mg every 4 weeks and the first injection should be taken during the first 5 days of the menstrual cycle. The duration of preoperative treatment of uterine fibroids with Diphereline 3 75mg should not be longer than 3 months.
3.2. Instructions for proper use of Diphereline 3 75mg Diphereline 3 75mg is administered by injection, used for children over 5 years old and adults. Before injecting Diphereline 3 75mg, patients need to follow all instructions of their doctor to ensure safe and effective use of the drug.

4. Diphereline 3 75mg side effects

Diphereline 3 75mg medicine can cause patients to experience some of the following side effects during treatment:
Very common reactions: Hot flashes, paresthesias in the lower extremities, increased sweating, asthenia, backache. Common Reactions: Headache, dizziness, depression, musculoskeletal pain, nausea, fatigue or loss of libido. Uncommon reactions: Gout, anorexia, paresthesia, insomnia, dyspnea, hypertension, tinnitus, constipation, abdominal pain, vomiting, diarrhea, rash or itching. Rare reactions: Purpura, nasopharyngitis, diabetes mellitus, memory impairment, confusion, anaphylactic reactions, dizziness, abdominal distention or epistaxis. Patients should notify their doctor immediately if they notice the appearance of one or more of the side effects mentioned above while taking Diphereline 3 75mg.

5. Precautions when using Diphereline 3 75mg

5.1. What precautions should be taken during treatment with Diphereline 3 75mg? Here are the things that patients need to note and be careful about while using Diphereline 3 75mg, including:
Caution when treating with Diphereline 3 75mg for children < 18 years old and patients with osteoporosis . While taking Diphereline 3 75mg, patients should avoid drinking alcohol or abusing stimulants, because this can increase the risk of experiencing adverse effects. Inject Diphereline 3 75mg according to the dose and time prescribed by the treating doctor. Avoid injecting Diphereline 3 75mg that has expired, the powder shows signs of discoloration, mold or other abnormalities such as cloudiness or precipitation after reconstitution. If the drug Diphereline 3 75mg has expired, the patient needs to handle the drug according to the requirements and instructions of the medical professional. Diphereline 3 75mg injection solution should only be mixed immediately before use. The risk of bone loss may be increased with the use of GnRH agonists. Therefore, special caution should be taken when administering Diphereline 3 75mg to patients with risk factors for osteoporosis, such as smoking, chronic alcoholism, family history of osteoporosis, malnutrition , are on long-term treatment with drugs that reduce bone density such as corticosteroids or anticonvulsants. Do not use Diphereline 3 75mg for pregnant women. Treatment with Triptorelin may increase the risk of major depression. Diphereline 3 75mg should be used with caution in people who have been treated with anticoagulants because it may lead to a risk of blood accumulation at the injection site. 5.2. Interactions of Diphereline 3 75mg with other drugs The following are drugs that can interact with Diphereline 3 75mg, including:
Drugs affecting the secretion of Gonadotropins by the pituitary gland. Medicinal products capable of prolonging the QT interval. Drugs that cause twisting points, such as class IA (Disopyramide, Quinidine), class III (Dofetilide, Sotalol, Ibutilide, and Amiodarone). Antiarrhythmic drugs. Moxifloxacin drug. Methadone drug . Antipsychotic drugs. Diphereline 3 75mg belongs to the ETC group of drugs, used to treat conditions such as prostate cancer, stage I-IV endometriosis, precocious puberty in both boys and girls, female infertility or female infertility. preoperative treatment of uterine fibroids.
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