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Dimoxiti drug has the main active ingredient is Diacerein with a concentration of 50mg and other excipients in sufficient quantities. This is a pain reliever, antipyretic, non-Steroid anti-inflammatory drug and treatment of bone and joint diseases.
1. What is Dimoxiti?
What is Dimoxiti? Dimoxiti drug has the main active ingredient is Diacerein with a concentration of 50mg and other excipients in sufficient quantities. This is a pain reliever, antipyretic, non-steroid anti-inflammatory drug and treatment of bone and joint diseases.
Dimoxiti is made in the form of hard capsules, suitable for direct oral use. Packing is a box of 2 blisters, each blister contains 10 capsules.
1.1. Pharmacodynamics of the main active ingredient Diacerein The results of several in-vitro and in-vivo studies indicate that the active substance Diacerein and Rhein, its active metabolite, inhibit the production and activity of Interleukin. -first. Interleukin-1 is a proinflammatory and pro-catabolic agent, both in the superficial and deep layers of cartilage, in the synovial membrane and in the synovial fluid. At the same time, Interleukin-1 stimulates the production of transforming growth factor-α (TGF-β) and components of extracellular matrix such as proteoglycan, aggrecan, hyaluronic acid and type II collagen. In addition, these substances also have the ability to inhibit the phagocytosis and migration of macrophages. In studies in several animal models of osteoarthritis, the active ingredient Diacerein reduced cartilage degeneration compared with the untreated group. Clinical studies have shown significant pain relief and significant improvement in joint function compared with placebo after 1 month of treatment with Diacerein. Other studies have also shown that the beneficial effects of Diacerein treatment persist for at least 2 months after treatment has been discontinued.
1.2. Pharmacokinetics of the active substance Diacerein After oral administration, the active substance Diacerein passes through the liver and is completely deacetylated to rhein. The half-life of rhein averages about 4.5 hours. The total amount of drug excreted from the body in the urine is about 30%. About 80% of rhein is excreted in the urine as sulpho-glucurose conjugates and about 20% as unchanged rhein. After repeated dosing (50 mg twice daily), Diacerein showed a slight potential for accumulation. In patients with severe renal impairment with creatinine clearance less than 30 ml/min, the AUC and half-life were doubled and urinary excretion was halved.
2. What diseases does Dimoxiti treat?
What disease does Dimoxiti treat? Dimoxiti is used in the treatment of signs and symptoms of osteoarthritis.
3. Usage and dosage of Dimoxiti
Usage and dosage of Dimoxiti drug as follows:
Dimoxiti drug is prepared in the form of hard capsules, suitable for direct oral use. For adults: Take 2 tablets daily, divided into 2 times, with meals. For patients with renal impairment: Reduce by half the dose for patients with renal impairment with creatinine clearance less than 30 ml/min. It should be noted: the dosage of the above medicine is for reference only, the patient should take the drug according to the instructions of the doctor prescribing and consulting. Because each person will have a different condition and response to medication.
4. Undesirable effects of the drug Dimoxiti
During the use of Dimoxiti, patients may experience some of the following side effects:
Common undesirable effects when treated with Dimoxiti are a rapid increase in the time for food to pass through the intestines and abdominal pain. These signs and symptoms may appear during the first few days of treatment and, in most cases, they resolve spontaneously with continued treatment. Using Dimoxiti may make your urine darker yellow. You need to actively inform the treating doctor about the unwanted effects encountered when using Dimoxiti medicine so that the doctor can change and adjust the dosage if necessary.
5. Some notes when using Dimoxiti
During the use of Dimoxiti, patients may experience some of the following side effects:
5.1. Contraindications of the drug Dimoxiti Contraindicated with the drug Dimoxiti in the following cases:
People with a history of sensitivity or hypersensitivity to the main active ingredient Diacerein and its components. Persons with a history of hypersensitivity to Anthraquinone derivatives. 5.2. Notes and precautions of the drug Dimoxiti should not be prescribed to children under 15 years of age, because there are no clinical studies on subjects using the drug in this age group. Dimoxiti should not be used concurrently with laxatives. Interactions with other drugs, other forms of interaction: The concomitant use of Dimoxide should be avoided with drugs containing salts, oxides or hydroxides of aluminum, calcium and magnesium. This is because these drugs reduce the absorption of the active ingredient Diacerein. You can use these substances at a different time (more than 2 hours apart) after taking Dimoxiti . Use in pregnancy and lactation: Dimoxiti should not be used by pregnant women. In addition, Dimoxiti should not be prescribed to women who are breastfeeding. This is because it has been reported that small amounts of diacerein derivatives pass into breast milk. Effects of drugs on driving and operating machines: There are currently no specific reports on the harmful effects of Diacerein on the ability to concentrate when driving or operating machinery and equipment. . Store Dimoxiti in a dry place, away from direct light. In addition, you need to keep the medicine out of the reach of children and household pets.
Above is all information about Dimoxiti, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Dimoxiti to treat diseases at home, because there may be unwanted side effects on health.
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