This is an automatically translated article.
Diclofenac has the main content of diclofenac sodium, accounting for 100mg. With this content, Diclofenac Stada will support pain relief and fever reduction. To better understand the function and principle of action of the drug, please refer to the article below.
1. Learn about the drug Diclofenac Stada
As a pharmaceutical product manufactured by STADA - Vietnam Joint Venture Company, Diclofenac Stada contains the main ingredient diclofenac sodium with a content of 100mg. This is a drug that belongs to the NSAID group. Therefore, it will have the effect of antipyretic, pain reliever, non-steroidal anti-inflammatory. The property of diclofenac sodium is that it will quickly take effect as soon as it enters the body, they inhibit the synthesis of prostaglandins - a substance that affects the process of inflammation, fever, and pain in the body. Because of this, diclofenac sodium is fast and powerful, eliminating moderate to severe muscle pain in the body and especially from arthritis or other acute pain caused by trauma.
2. Uses and indications of Diclofenac Stada
Diclofenac Stada 100mg will apply to cases such as:
Support for pain relief and widespread inflammation; Treatment of diseases from arthritis such as: tendinitis, bursitis, osteoarthritis, tenosynovitis, periarthritis (eg stiff shoulder), ankylosing spondylitis, rheumatoid arthritis... Pain in cases of trauma such as low back pain, sprains, orthopedic surgery, muscle strains, fractures, dislocations...
3. The effect of Diclofenac Stada on the body
Diclofenac is a member of the phenylacetic acid family of derivatives and is also the primary non-steroidal anti-inflammatory drug (NSAID). Therefore, Diclofenac has similar pharmacological activities as other primitive NSAIDs supporting anti-inflammatory, antipyretic and analgesic. Although the mechanism of action has not been clearly analyzed, the main effect will be related to inhibition of prostaglandin synthesis.Diclofenac's mechanism of inhibiting prostaglandin synthesis in the body is by acting on cyclooxygenase. Specifically, it will inhibit at least two cyclooxygenase isoenzymes -1 (COX - 1) and -2 (COX - 2) (prostaglandin G/H synthase - 1 [PGHS-1] and -2 [PGHS - 2, respectively) ] corresponding). These are the catalysts for the formation of prostaglandins in the arachidonic acid pathway.
4. Effects of the body on the drug Diclofenac Stada
The drug is completely absorbed by the body and can be delayed on the stomach side by food. The average concentration of diclofenac in the blood is 1.48 + 0.65pg/ml, this index is achieved after 2 hours of using 50mg of the drug;
Diclofenac distribution: 99.7% bound to protein and 99.4% bound to albumin. When entering the synovial fluid, the concentration of Diclofenac will reach the maximum after 2-4 hours. After 3 to 6 hours, the drug will be eliminated from the synovial fluid. After 2 hours of reaching peak plasma concentrations, diclofenac concentrations in the synovial fluid will be higher than those in plasma and persist for up to 12 hours.
The glucuronidation of the intact diclofenac molecule results in partial metabolism of diclofenac. Diclofenac is largely metabolized by one or more hydroxylation and methoxylation, resulting in several phenolic metabolites, most of which are converted to glucuronide conjugates. These substances are biologically active but weaker than diclofenac.
The total elimination of diclofenac in plasma is 263 + 56 ml/min, the terminal half-life is 1-2 hours. In the metabolites there are 2 active substances with short plasma half-lives of 1-3 hours. 60% of diclofenac is excreted in the urine. Less than 1% will be eliminated unchanged, the rest is metabolized in the bile via feces.
5. Recommended dosage of Diclofenac
The drug is absorbed orally, should be swallowed whole, rather than chewed or crushed. To avoid side effects, the lowest effective dose should be used to quickly control the condition.
Should take from 75-150mg / day to take 2 to 3 times. This is a reference dose, for the most effective oral dose, please consult a professional doctor.
6. Undesirable effects of taking Diclofenac
About 10% of patients will experience side effects in the digestive system;
Using diclofenac has an increased risk of cardiovascular thrombotic complications such as stroke, myocardial infarction ...
Common conditions: Upper abdominal pain, vomiting, headache, bloating, indigestion, loss of appetite, increased transaminases, tinnitus..
Less common conditions such as edema, allergic reactions, sleep changes, nodules, gastrointestinal bleeding, defecation, vomiting blood, irritability, irritability, Stevens - Johnson syndrome, hair loss, encephalitis.....
7. Notes when using Diclofenac
Cases not indicated for use:
Allergy and hypersensitivity to diclofenac other NSAIDs Severe stomach ulcers; Do not take the drug while taking coumarin anticoagulants; People with bleeding disorders, severe liver-kidney failure, cardiovascular disease, bronchospasm; People with aseptic meningitis or autoimmune diseases; Heart diseases such as heart failure, anemia... Other notes such as:
This drug should not be substituted for corticosteroids or for the treatment of corticosteroid deficiencies; May compromise the usefulness of diagnosing fever and infectious tablets by the pharmacological action of diclofenac; People with liver dysfunction or liver diseases should pay attention to monitoring when using the drug; Hemoglobin or red blood cell volume should be checked if any symptoms of anemia are observed during prolonged use of diclofenac. In summary, Diclofenac Stada is effective in supporting pain relief and fever reduction. Before taking the drug, the patient should carefully read the instructions before use and if necessary, consult a specialist.
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