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Devastin 10mg is a drug that has the effect of lowering blood fat, a statin drug. It is used when hypercholesterolemia cannot be controlled by non-pharmacological measures such as diet and exercise.
1. Uses of Devastin 10mg
Devastin 10mg drug has the same main ingredient as Rosuvastatin 10mg. The drug is available in the form of film-coated tablets. Rosuvastatin is a drug belonging to the Statin group, the mechanism of action is by selectively and competitively inhibiting the enzyme hydroxymethylglutaryl coenzyme (HMG-CoA) reductase, thereby preventing the conversion of HMG - CoA into mevalonic acid, which is a prodrug. cholesterol substance. From there, it helps to lower blood cholesterol and helps lower LDL- cholesterol and increase HDL-cholesterol.
2. Indications and contraindications of Devastin 10mg
The drug is indicated in the following cases:
Hyperlipidemia type IIa is an inherited form of high blood cholesterol and is often accompanied by increased LDL-don in the blood. Type IIb hyperlipidemia is a combination of genetic and other causes of high cholesterol. In both cases, when combined with diet and exercise, there is no improvement, then Devastin 10mg is indicated in combination to help control blood fat and reduce the risk of cardiovascular disease. Besides, during the course of taking the drug, the patient still needs to continue the diet and exercise according to the doctor's instructions..
Contraindication to Devastin 10mg drug in the following cases:
Patient has a history Hypersensitivity to rosuvastatin or any of the other excipients of the drug. Patients with liver disease or unexplained persistent elevations in serum transaminases or when serum transaminase levels are increased more than 3 times the upper limit of normal. Patients with severe renal impairment when creatinine clearance < 30 ml/min. The patient has musculoskeletal disorders. Patient is taking cyclosporin. Pregnant and lactating women, women can become pregnant while taking the drug, if appropriate methods of contraception are used. Therefore, women need to use appropriate contraception.
3. Usage and dosage of Devastin 10mg
Devastin 10mg is to be taken orally with water. Rosuvastatin can be taken at any time of the day, with or without meals. However, to avoid forgetting the medicine, the patient should take the medicine at a fixed time of the day.
Specific dosing is as follows:
The recommended starting dose is 10 mg orally once a day and most patients are controlled even with this starting dose. If not well controlled, the dose can be increased to 20mg after 4 weeks. An increase in the maximum dose to 40 mg should only be used in patients with severe hypercholesterolemia and at high risk of cardiovascular disease who have not achieved their therapeutic goals at 20 mg, and patients receiving this dose should be monitored. monitor regularly. When co-administered with drugs such as Atazanavir, Ritonavir or Lopinavir, the dose of Rosuvastatin should be limited to a maximum of 10 mg once daily. Elderly: No dose adjustment is required. Patients with renal impairment: No dose adjustment is required in patients with mild to moderate renal impairment. For children under 8 years of age: Safety and effectiveness in children have not been specifically studied. Pediatric experience is limited to a small group of children (≥ 8 years) with homozygous familial hypercholesterolemia. Therefore, Rosuvastatin is not recommended for use in children under 8 years of age.
4. Side effects when taking Devastin 10mg
Like other drugs, when taking this drug, it can also cause some unwanted effects such as:
Common: Headache, dizziness, constipation, nausea and vomiting, abdominal pain, itching, rash rash, urticaria, myalgia, asthenia. Rare: Causes hypersensitivity reactions such as anaphylaxis, angioedema, myopathy, rhabdomyolysis, with a predisposition to drug dependence. If you experience these side effects. Patients need to go to the medical facility for timely treatment. There are also some other undesirable effects that may occur such as: cognitive impairment (memory loss, confusion...), increased blood sugar, increased HbA1c index. Like other statins, this drug can also cause elevation of liver enzymes.
5. Notes when taking Devastin 10mg
Some notes in the process of taking Devastin 10mg as follows:
You need to inform your doctor about a history of allergy to the drug or other statin drugs, a history of muscle toxicity due to inhibitors. Other HMG-CoA reductase-induced enzymes or fibrates, the existing diseases. From there, take appropriate medication and monitoring measures. Liver enzyme tests should be performed prior to initiating statin therapy and may be required in each case thereafter. When taking drugs at high doses, it is necessary to monitor the creatine kinase (CK) enzyme index, because the risk of effects on skeletal muscle causing rhabdomyolysis is very dangerous. Before treatment, it is necessary to test CK in cases such as: impaired renal function, hypothyroidism, personal or family history of hereditary myopathy, history of drug-induced myopathy previous statin or fibrate group, history of liver disease, heavy alcohol intake, elderly patients (>70 years) with risk factors for rhabdomyolysis. In these cases, the benefits and risks of adverse events should be carefully weighed, and patients should be monitored clinically during statin therapy. If the CK test result is > 5 times the upper limit of normal, statin therapy should not be initiated. During treatment with statin drugs, patients need to report when there are muscle symptoms such as muscle pain, muscle stiffness, muscle weakness... Need to conduct blood test CK index to be monitored and timely treatment. Drug interactions may occur when Rosuvastatin is used concomitantly with drugs for the treatment of HIV and hepatitis C virus (HCV). It can increase the risk of muscle damage, most seriously causing rhabdomyolysis, kidney failure and possibly death. Therefore, caution should be exercised when combining. While taking the drug, you still need to follow a lipid-lowering diet and exercise regularly to maintain a reasonable weight. Do not use the medicine if there are signs of damage or expiry date. Storage: should be stored in a closed place, away from moisture, away from direct light and at a storage temperature below 30 ̊C. Keep out of reach of CHILDREN. Devastin 10mg should be used under the direction of a doctor and should be closely monitored during treatment, especially in people with high risk factors for complications. When there is an abnormality, you should consult your doctor for timely treatment.
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