This is an automatically translated article.
Desfonak belongs to the group of emergency and antidote drugs, with the main ingredient being the active ingredient Deferoxamine Mesylate. Adhering to the indications, the dose of Desfonak drug will help patients improve the effectiveness of treatment and avoid unwanted side effects.1. What is Desfonak?
Desfonak is a drug to treat poisoning, blood poisoning, with the main ingredient being the active ingredient Deferoxamine Mesylate. Desfonak drug is prepared in the form of lyophilized powder for injection, packed in 1 box including 10 small vials.2. What are the effects of Desfonak?
The effect of Deferoxamine Mesylate in the drug Desfonak to treat cases of iron excess without affecting electrolytes as well as other metals in the body.
The mechanism of action of the drug Desfonak is as follows:
The drug Deferoxamine Mesylate when entering the body will be activated to cut the ester to form an active substance called Deferoxamine. This substance has a high affinity and selectively forms complexes with Iron III (Fe3+) ions. Deferoxamine-Fe3+ complex after formation will be transported by color and excreted by the kidneys easily. In particular, Deferoxamine does not increase the excretion of trace metals as well as other electrolytes present in the body.
Desfonak drug is indicated for use in the following cases:
Patients with serum iron levels above 450 - 500μg/dl, acute iron poisoning that can be fatal (iron dose 180-300mg/kg or calculated by iron). element) or when clinical signs of severe iron toxicity (convulsions, shock, coma) appear. The patient was diagnosed and treated with primary iron deficiency. In patients with chronic iron overload secondary to congenital anemia, regular blood transfusion in the treatment of thalassemia and other anemias. Patients using drugs and iron supplements improperly cause iron poisoning. Patients with renal failure are being treated for aluminum accumulation (serum aluminum concentration above 60μg/l).
3. Usage of Desfonak
3.1. How to use Desfonak Patients use Desfonak through injection. Desfonak drug is allowed to enter the patient's body through intramuscular injection, slow intravenous infusion and subcutaneous infusion through a metered infusion machine.
For intramuscular and subcutaneous injection: Add 2 or 5ml of sterile water to 1 vial to get a solution with a concentration of 250mg/ml or 100mg/ml respectively. For intravenous infusion: Add 0.9% Sodium Chloride solution, Ringer Lactate solution or 5% Dextrose solution to 1 vial. Infusion at a rate not to exceed 15 mg/kg/hour for the first 1000 mg. And infuse at a rate not exceeding 125mg/hour at a later time. For subcutaneous infusion: Infusion rate from 20-40mg/kg over 8-24 hours. Night is the most suitable time for infusion when it must be administered subcutaneously for 8-12 hours. 3.2. Dosage of Desfonak The dose of the drug prescribed by the doctor is based on the medical condition of each patient.
Treatment of acute iron poisoning:
Adults: Use by intramuscular route, each injection is 4-12 hours apart with the first dose of 1g, after about 4 hours, inject the next dose with a dose of 0.5g. The maximum dose used in a day is 6g. Administer intravenously with a maximum daily dose not exceeding 6g and an infusion rate of 15mg/kg/hour. Children: The maximum dose used in a day should not exceed 6g. It can be administered intramuscularly every 6 hours at a dose of 50mg/kg/time or intravenously at the same dose as intravenous infusion. Chronic iron overload:
Adults: Use by intramuscular route, using a dose of 0.5-1g/day. Use by subcutaneous infusion with specialized tools at a dose of 1-2g/day. Children: 15mg/kg IV every hour for a maximum of 12 hours, or 20-50mg/kg/day subcutaneously. Thalassemia:
Use by slow intravenous infusion at a dose of 2g/unit of blood during blood transfusion. Accumulation of aluminum in patients with renal failure:
Each dialysis dose is 20-40mg/kg, the number of times of drug use must be according to the doctor's prescription based on the clinical basis of the patient. 3.3. Handling when forgetting, overdosing Missed dose:
The process of taking Desfonak medicine into the patient's body is done by medical staff to minimize the phenomenon of missed dose. If this is not the case, notify your doctor immediately.
Overdose:
In the case of an overdose of Desfonak, the patient may experience symptoms such as tachycardia, hypotension and gastrointestinal symptoms. In this case, contact your doctor immediately and follow the instructions of your doctor.
3.4. Contraindications to the drug Desfonak is contraindicated in patients with severe renal failure or anuria, active infections and hypersensitivity to the components of the drug.
4. Notes when using the drug Desfonak
Desfonak is prescribed and sold by prescription. Patients do not voluntarily use. Do not use Desfonak drug for pregnant women (especially in the early stages) and women who are breastfeeding need a doctor's prescription. Rapid intravenous injection may cause some phenomena such as hypotension, urticaria, skin flushing, shock in some patients. Side effects of Desfonak:
When using Desfonak, patients may experience side effects including:
Common: Rash, itching, swelling, erythema, pain. It may sometimes be accompanied by chills, fever and fatigue. Uncommon: Itching, dizziness, abdominal pain, angioedema, urticaria, night blindness, vitreous involvement, increased transaminases, anaphylactoid reactions with or without anaphylaxis... Interactions Desfonak drug
Patients should be careful when using Desfonak concurrently with the following drugs:
Vitamin C: May cause cardiac arrhythmias. Prochlorperazine: Ability to temporarily lose consciousness. Store Desfonak medicine
Store Desfonak medicine in a cool, dry place, away from direct sunlight. The appropriate storage temperature for Desfonak medicine is at room temperature, below 30 degrees Celsius. Do not use Desfonak when the expiry date printed on the package, color change, or taste change. Keep Desfonak out of the reach of children. Above is all information about Desfonak drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Desfonak drugs for home treatment because there may be unwanted side effects.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
