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Davibest medicine contains the main active ingredient Trazodone and other excipients with a sufficient amount of 1 tablet. Drugs belonging to the group of drugs with strong antidepressant effects should be used in the treatment of symptoms of all forms of depression. Davibest drug is prepared in the form of tablets, used orally.
1. What is Davibest drug? What are the uses of Davibest?
Davibest is indicated in the treatment of symptomatic relief of all forms of depression, including associated anxiety.
1.1. Pharmacodynamics of Davibest Drugs Main active ingredient Trazodone is a potent antidepressant. The drug is also active in reducing anxiety. Active ingredient Trazodone hydrochloride is a derivative of triazole pyridine that is not chemically related to tricyclic, 4-cyclic antidepressants and other classes of antidepressants. Davibest has a negligible effect on the reabsorption mechanism of noradrenaline.
Although the mechanism of action of trazodone hydrochloride is unknown, its antidepressant effects may be related to noradrenergic stimulation not by a mechanism of absorption blocking. The anxiolytic effect of the drug may be due to central serotonin inhibition.
1.2. Pharmacokinetics of Davibest Drug Absorption: Trazodone is rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved approximately 1 hour after administration of Trazodone hydrochloride in the fasted state and 2 hours if Davibest is taken with food. Distribution: Distribution of Davibest in human tissues and fluids has not been determined. Davibest crosses the blood-brain barrier in animals and brain concentrations are higher than in plasma within the first 8 hours after oral administration. Trazodone is 85-95% bound to plasma proteins. Metabolism: Trazodone is extensively metabolised in the liver. Elimination: Trazodone is excreted in the urine almost entirely as metabolites, either free or conjugated. Elimination of the drug Trazodone consists of two phases with a terminal half-life of 5 to 9 hours. Trazodone is excreted in human milk.
2. Usage and dosage of Davibest
2.1. How to use Davibest: Davibest is made in the form of tablets, suitable for oral use of Davibest.
2.2. Dosage of the drug Davibest Treatment of depression
For adults: The starting dose is 150 mg/day divided into several doses orally after meals or once before bedtime. The therapeutic dose may be increased to 300 mg/day administered once or in divided doses.
Elderly: In the very elderly or frail, the recommended starting dose is reduced to 100 mg/day in divided doses or once at bedtime. The treating physician may gradually increase the dose under the supervision of the treating physician, based on efficacy and tolerability. In general, single therapeutic doses above 100 mg should be avoided in these patients. Typically, a therapeutic dose of 300 mg/day will not be exceeded. Children: There is no information to recommend the use of Trazodone for children under 18 years of age. Treatment of depression with anxiety
The treatment dose is the same as for treatment of depression .
Treatment of anxiety
Treatment dose is 75mg/day increased to 300mg/day if necessary. The undesirable effects of Trazodone (increased reabsorption and decreased peak plasma concentrations) can be reduced by taking Davibest after a meal. Use of drugs for people with liver failure: Trazodone hydrochloride is extensively metabolized in the liver and is also toxic on the liver. Therefore, you should use caution when using the drug in people with liver failure, especially in cases of severe liver failure. Your doctor will prescribe regular monitoring and evaluation of liver function.
Use of the drug in people with renal impairment: Usually no dose adjustment is required, but caution should be used when using the drug in people with severe renal impairment.
2.3. Case of Davibest Overdose Case of Davibest Drug Overdose: Commonly reported reactions in overdose are drowsiness, dizziness, nausea and vomiting. In severe cases may cause coma, tachycardia, hypotension, hyponatremia, convulsions and respiratory failure, bradycardia, prolongation of the QT interval and torsades de pointes. Symptoms may appear 24 hours after overdose. Overdose of Davibest when taken with other antidepressants can cause Serotonin syndrome.
Treatment: Currently, there is no specific antidote for Davibest overdose. Your doctor may consider using the following treatments:
Use activated charcoal in adults who take more than 1g of Trazodone or in children who take more than 150mg of Trazodone within 1 hour of symptoms. For adults, the treating physician may consider switching to gastric lavage within 1 hour of a potentially life-threatening overdose. Monitor vital signs including temperature, breathing rate, blood pressure, and pulse for at least 6 hours after ingestion (or 12 hours if extended-release formulation is used). Assess status according to the Glasgow Coma Scale (GCS). Monitor blood oxygen saturation (SpO2). There is no need to treat a brief single seizure. Control frequent or prolonged seizures with intravenous diazepam (0.1 - 0.3 mg/kg body weight) or lorazepam (4 mg in adults and 0.05 mg/kg in children) em). If the seizures cannot be controlled with the above measures, the treating doctor may prescribe intravenous phenytoin. Administer oxygen, correct acid base and metabolic disturbances if necessary. The treating doctor will prescribe symptomatic and supportive treatment in case of prolonged hypotension and sedation. If hypotension is severe, persistent, consider inotropic agents such as dopamine or dobutamine.
3. Undesirable effects of the drug Davibest
Cases of suicidal ideation and suicidal behavior have been reported while using Davibest or soon after stopping treatment. Davibest has no effect on arterial blood pCO2 or pO2 levels in people with severe respiratory failure due to chronic lung or bronchial disease.
Undesirable effects on organ systems in the body include:
Blood and lymphatic system: Hematopoietic disorders such as agranulocytosis, thrombocytopenia, eosinophilia, leukopenia and anemia blood. Immune system: Allergic reaction. Endocrine: Syndrome of inappropriate antidiuretic hormone secretion. Metabolism and nutrition: Hyponatremia, weight loss, anorexia. Psychiatric: Presence of suicidal ideation or behavior, confusional state, insomnia, disorientation, mania, anxiety, nervousness, agitation, delusions, agitated behavior, hallucinations , nightmares, decreased libido, withdrawal syndrome or delirium. Neurological: serotonin syndrome, neuroleptic malignant syndrome, dizziness, dizziness, headache, somnolence, decreased reflexes, tremor, blurred vision, memory disturbance, myoclonic tremor, aphasia , paresthesia, dystonia, altered taste. Cardiovascular system: Arrhythmia, arrhythmia, ECG abnormalities (prolongation of the QT interval), orthostatic hypotension, hypertension, syncope. Respiratory system: Nasal congestion, difficulty breathing. Digestive system: Nausea, vomiting, dry mouth, digestive disorders, dyspepsia, abdominal pain, gastritis, increased salivation, intestinal paralysis, liver function abnormalities (including jaundice, cell damage liver), intrahepatic cholestasis. Skin and subcutaneous tissues: Rash, redness of the skin, itching, increased sweating. Musculoskeletal system and connective tissue: Pain in the extremities, back pain, muscle pain, joint pain. Urinary system: Urinary disorders. Genitourinary system and mammary glands: Penile erection in men. Body as a Whole: Feeling of weakness, edema, flu-like symptoms, exhaustion, chest pain, fever. Laboratory tests: Increased liver enzymes. Davibest drug may cause other unwanted effects, when you encounter any unwanted signs during the use of the drug, you need to immediately notify the treating doctor for timely treatment and right way.
4. Davibest drug interactions
General interactions: When using Davibest, it can increase the sedative effect of neuroleptics, tranquilizers, anti-anxiety drugs, sleeping pills. The doctor will prescribe a reduction in the treatment dose in these cases. The metabolism of antidepressants is increased by the liver effects of oral contraceptives such as Phenytoin, Carbamazepine and Barbiturates. Metabolism of antidepressants is inhibited by cimetidine and some other psychoactive drugs. In vitro studies have shown that Trazodone has the ability to interact with strong inhibitors of CYP3A4 such as erythromycin, ketoconazole, itraconazole, ritonavir, indinavir, resulting in increased plasma concentrations of Trazodone. Davibest can increase the effect of muscle relaxants and volatile anesthetics, so caution should be taken when used in combination. Davibest enhances the sedative effect of sedative drugs, including alcohol. Do not consume alcoholic beverages or alcohol while you are being treated with Trazodone. Tricyclic antidepressants: Should be avoided in combination with Davibest because of the risk of interaction causing Serotonin syndrome and undesirable effects on the cardiovascular system. Fluoxetine: Rarely, increased plasma concentrations of trazodone have been reported. Monoamine oxidase inhibitors: Do not co-administer MAOIs with Davibest and do not take one within two weeks of stopping the other. Phenothiazines, fluphenazines, chlorpromazines, levomepromazines and perphenazins: Serious orthostatic hypotension may be caused when used concurrently with Davibest. Concomitant use of Davibest with drugs known to prolong the QT interval may increase the risk of ventricular arrhythmias, including torsades de pointes. Warfarin: May cause changes in blood clotting time. Phenytoin, digoxin: Increased serum concentrations of the drugs phenytoin and digoxin.
5. Some notes when using Davibest drug
Before using the drug Davibest you need to carefully read the instructions for use and refer to the information below:
5.1. Contraindications of the drug Davibest Drug Davibest is contraindicated in the following cases:
People with hypersensitivity to the drug Trazodone or to any of its ingredients. Alcohol intoxication or intoxication with sleeping pills. Patients with acute myocardial infarction. 5.2. Precautions while using Davibest Trazodone should be used with caution in people with urinary retention related to porphyria. Experiencing suicide/suicidal thoughts and worsening condition: People with depression and neurosis may find their depression worsens. However, antidepressants may play a role in the worsening of depression and the emergence of suicidal ideation in some people in the early stages of treatment. Use for children and adolescents under 18 years of age: Davibest should not be used by children or adolescents under 18 years of age. Currently, there is still a lack of safety information on growth, maturation, cognitive and behavioral development with prolonged use of Davibest in children or adolescents. 5.3. Note to special subjects: For pregnant women: Limited information shows that there are no unwanted effects of Davibest drug on pregnant women or on the health of the fetus or newborn. born. As a general rule, the use of Davibest should be avoided during the first trimester of pregnancy. For women who are breastfeeding: Use caution when using Davibest for pregnant women. Women who use Davibest until delivery should be monitored for the appearance of signs of withdrawal symptoms in the newborn. Effects of the drug on the job, especially those who operate machinery, people who are driving vehicles, people working at height and other cases: Davibest drug causes little effect on the ability to drive or ability to drive. machine operation. As with drugs that act on the central nervous system, you should be aware of the risks when driving or operating machinery. Only drive or operate machinery until you are certain you are not experiencing the side effects of drowsiness, sedation, dizziness, confusion, or blurred vision caused by the medication. Davibest medicine contains the main active ingredient Trazodone and other excipients with a sufficient amount of 1 tablet. Drugs belonging to the group of drugs with strong antidepressant effects should be used in the treatment of symptoms of all forms of depression. To ensure the effectiveness of treatment and avoid side effects, patients need to take the medicine exactly as directed by the doctor, professional pharmacist.
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