This is an automatically translated article.
Daspa medicine has the main ingredient is Arginin hydrochloride, has a hepatotropic effect, lowers ammonia, increases detoxification and eliminates ammonia in case of genetic impairment of urea production. Daspa drug is often indicated in the treatment of digestive disorders, indigestion.
1. What are the effects of Daspa?
What does Daspa do? Daspa medicine has the main ingredient is Arginin hydrochloride. The drug has a hepatotropic effect, lowering blood ammonia, increasing detoxification and eliminating ammonia in the form of citrulline in cases of hereditary impairment of urea production. The drug is indicated in the treatment of digestive disorders, indigestion.
Arginin is well absorbed from the gastrointestinal tract, peak plasma concentrations are reached 2 hours after dosing. Arginin is metabolized by the liver to ornithin and urea by hydrolysis of the guanidine group. The drug is filtered by the glomerulus and reabsorbed almost entirely in the renal tubules.
2. What is the dosage of Daspa?
The recommended dose of Daspa in adult patients is 15 - 30 tablets/day
3. Contraindications of Daspa
Daspa is contraindicated in the following cases:
Patients with hypersensitivity to any ingredient in the formula Patients with atopic allergies Patients with urea cycle disorders accompanied by arginase enzyme deficiency . Patients with chronic renal failure
4. Undesirable effects of Daspa
Patients using Daspa may experience undesirable effects including: Abdominal pain, abdominal distention, thrombocytopenia, cyanosis of extremities, sickle cell anemia, increased BUN, creatinine and serum creatine , nausea, vomiting, flushing, headache, frostbite. In addition, cases of hyperkalemia have been reported in patients with uremia. Patients should inform their doctor about the undesirable effects encountered when taking Daspa.
5. Be careful when using Daspa
During the use of Daspa, the following should be noted:
The patient should stop taking the drug if diarrhea occurs. Daspa may alter the ratio of extracellular to intracellular potassium; plasma potassium concentrations may be increased with arginine administration in patients with renal impairment. Daspa should be used with caution in patients with renal disease or dysuria. The use of high doses of Arginin to treat acute blood ammonia infection can cause metabolic acidosis due to hyperchloremia. Therefore, plasma chloride and bicarbonate levels should be monitored, and the corresponding bicarbonate supplementation Arginin is not effective in the treatment of hyperammonemia due to organic acid disorders and should not be used in such disorders. An overdose of Daspa may lead to transient metabolic acidosis accompanied by tachypnea. Overdose in children can lead to hyperchloremia, cerebral edema or even death. Therefore, the extent of deficiency should be determined and an appropriate amount of alkylating agent calculated in the event of an overdose. Use caution when using Daspa in pregnant women, lactating women, patients with gallstones.
6. Daspa . drug interactions
Daspa when used concurrently with certain drugs can reduce the effectiveness or increase the risk of side effects. Therefore, the patient must inform the doctor of all drugs, vitamins, and dietary supplements being used for specific advice. The following are some notable drug interactions of Daspa:
Plasma insulin concentrations due to stimulation of arginine may be further increased by thiazide diuretics, xylitol and aminophylin. Long-term oral sulfonylurea antidiabetics may inhibit the response of plasma glucagon to arginine. In glucose-intolerant patients given glucose, phenytoin reduces the plasma insulin response to arginine. Hyperkalemia may occur when Arginin is used to treat metabolic alkalosis in patients with severe hepatic impairment who have recently received spironolactone. Above is an overview of Daspa medicine. To ensure the best effectiveness of the drug and prevent side effects, patients should consult a healthcare professional before use.
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