Miconazole, the main ingredient, has strong antifungal effects. This substance is formulated in various forms under different trade names, one of which is Daktarin Oral Gel 10g. So, what are the uses of Daktarin Oral Gel 10g?
1. What is Daktarin Oral Gel 10g?
Daktarin Oral Gel 10g is a product manufactured by Janssen - Cilag Ltd. (Thailand), with the main ingredient being Miconazole at a concentration of 20mg.
This medication is formulated as an oral gel with a white color and orange flavor. Each box contains one tube of 10g gel.
2. What are the effects of Daktarin Oral Gel 10g?
Miconazole in Daktarin Oral Gel 10g exhibits antifungal activity against both dermatophytes and yeast fungi. The effectiveness of this medication is based on Miconazole's ability to inhibit the biosynthesis of ergosterol in fungi. This leads to changes in the lipid composition of fungal cell membranes, ultimately causing the destruction of fungal cells.
3. Indications and contraindications of Daktarin Oral Gel 10g
Indications:
- Treatment of Candida infections in the oral cavity, oropharynx, and gastrointestinal tract.
- Daktarin Oral Gel 10g can only be used in adults and children aged 4 months or older.
Contraindications:
- Individuals with hypersensitivity to Miconazole, other imidazole derivatives, or any excipients in the gel.
- Children under 4 months of age.
- Infants with incomplete swallowing reflex development.
- Patients with liver dysfunction.
Concurrent use of Daktarin Oral Gel 10g with medications metabolized by the CYP3A4 enzyme, such as:
- Drugs that prolong the QT interval (e.g., Astemizole, Cisapride, Dofetilide, Mizolastine, Pimozide, Quinidine, Sertindole, and Terfenadine).
- HMG-CoA reductase inhibitors (e.g., Simvastatin, Lovastatin).
- Oral Triazolam and Midazolam.
4. Instructions for using Daktarin Oral Gel 10g
How to use:
- This gel is intended for oral use and should be taken after meals.
- A measuring spoon provided with the product delivers 124mg of Miconazole per 5ml of gel.
- For young children, each dose should be divided into smaller portions and applied directly to the affected area using a clean finger. Do not apply the gel to the back of the throat to avoid the risk of choking. Encourage children to hold the gel in their mouths as long as possible without swallowing immediately.
- Adults and children over 2 years old should use the gel after meals and keep it in their mouths for as long as possible before swallowing.
Dosage:
- Children aged 4–24 months: 1.25ml of gel (equivalent to 1/4 measuring spoon) per dose, 4 times daily.
- Adults and children over 2 years old: 2.5ml of gel (equivalent to 1/2 measuring spoon) per dose, 4 times daily.
- Treatment should continue for at least one week after symptoms of fungal infection disappear.
- In cases of oral Candida infections with dentures, the dentures should be removed in the evening and cleaned with the gel.
5. Side effects of Daktarin Oral Gel 10g
- Gastrointestinal disorders such as dry mouth, oral discomfort, nausea, or vomiting.
- Abnormal taste at the application site.
- Taste disturbance.
- Anaphylactic reactions and hypersensitivity.
- Choking.
- Diarrhea, stomatitis, and tongue discoloration.
- Angioedema, toxic epidermal necrolysis, Stevens-Johnson syndrome, urticaria, rash, acute generalized exanthematous pustulosis, and eosinophilia.
If any side effects occur, discontinue use and consult a doctor or visit the nearest hospital for timely diagnosis and treatment.
6. Precautions when using Daktarin Oral Gel 10g
- When using this medication concurrently with anticoagulants, closely monitor the anticoagulant effect and adjust the dose if necessary.
- Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with Daktarin Oral Gel 10g and other Miconazole formulations. Discontinue use if these reactions occur.
- Monitor Miconazole and Phenytoin levels if both drugs are used simultaneously.
- Patients with diabetes treated with oral sulfonylureas may experience severe hypoglycemia during concurrent use with Daktarin Oral Gel 10g. Consider appropriate management strategies.
Choking in infants and young children is a risk due to gel obstruction of the throat. For this reason:
- Do not apply the gel to the back of the throat.
- Divide doses into smaller portions for application.
- Ensure the child has a developed swallowing reflex before use.
Daktarin Oral Gel 10g contains a small amount of ethanol (less than 100mg per dose).
Severe skin reactions (e.g., toxic epidermal necrolysis and Stevens-Johnson syndrome) have been reported in patients using this gel. Inform a doctor immediately if signs of severe skin reactions occur.
Avoid using Daktarin Oral Gel 10g in pregnant women. The secretion of Miconazole into breast milk is unknown; therefore, exercise caution when using this medication in breastfeeding individuals.
7. Drug interactions with Daktarin Oral Gel 10g
Miconazole in Daktarin Oral Gel 10g inhibits the metabolism of drugs processed by the CYP3A4 and CYP2C9 enzyme systems, leading to prolonged effects or increased toxicity of these drugs.
Drugs requiring caution during concurrent use with Daktarin Oral Gel 10g:
- Oral anticoagulants (e.g., Warfarin).
- Oral hypoglycemic agents (e.g., sulfonylureas).
- Phenytoin.
- HIV protease inhibitors (e.g., Saquinavir).
- Cancer drugs (e.g., Vinca alkaloids, Busulfan, Docetaxel).
- Immunosuppressants (e.g., Cyclosporine, Tacrolimus, Sirolimus).
- Other drugs metabolized by CYP3A4 (e.g., Carbamazepine, Sildenafil, Alprazolam).
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