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Combikit contains the main active ingredients, Ticarcilin and Clavulanic Acid. The drug belongs to the group of anti-parasitic, anti-bacterial, anti-viral, anti-fungal drugs. So what does Combikit do?1. Effects of the drug Combikit
Combikit is indicated for use in the following cases:
Treatment of skin and soft tissue infections, upper and lower respiratory tract infections, ENT, urinary and genitourinary infections, severe urinary tract infections. Treatment in peritonitis, intra-abdominal infection, sepsis, myelitis, mixed infection after surgery. Combikit should not be used in patients with hypersensitivity or a history of hypersensitivity to beta-lactam antibiotics and penicillins. Also, should not be used in patients with mononucleosis or patients with a history of liver failure receiving penicillin antibiotics.
2. How to use and dose Combikit
2.1. Usage The use of Combikit is done by a doctor or medical staff, not for intramuscular injection, can be administered intravenously directly or by intermittent intravenous infusion. When using, it is necessary to dissolve Combikit 3.2g with 20ml of water for injection, inject slowly within 3-4 minutes, when the product is dissolved, there will be heat, the reconstituted solution turns pale yellow. Any remaining antibiotic solution should be discarded. For intravenous infusion of soluble 3.2 g with 100 ml of water for injection or 100 to 150 ml of glucose for intravenous infusion, the infusion should be given over 30 to 40 minutes, the preparation should be infused immediately after the solution is reconstituted. The infusion solution should be prepared under sterile conditions and when needed. 2.2. Dosage The usual dose of Combikit in adults (including the elderly):
For infections is: intravenous injection 1 tube 3.2g every 4 hours. Used for a period of 3 to 4 weeks, the dose should be customized according to the nature and severity of the infection. In patients with renal impairment : Mild renal impairment use a dose of 3.2g every 8 hours. Moderate renal failure: 1.6g every 8 hours. Severe renal impairment: 1.6g every 12 hours. Endometritis: Moderate infection is done intravenously at a dose of 50 mg/kg body weight (calculated on ticarcillin dose) every 6 hours. In severe infections, an intravenous dose of 50 mg/kg body weight (based on ticarcilin dose) should be administered every 4 hours. In children:
The usual dose is calculated according to the child's weight, 80 mg/kg body weight every 6 to 8 hours. For neonates, the dose is still 80 mg/kg body weight but every 12 hours, then increased every 8 hours. Children with renal impairment: the dose should be reduced as in adults.
3. Undesirable effects
When using Combikit, patients may experience some side effects such as: vomiting, nausea, headache, abdominal pain, flatulence, mild diarrhea, itching or rash, muscle pain, joint pain, swelling, pain or burning at the injection site, vaginal yeast infection (discharge or itching)....
In addition, when using Combikit, patients may experience serious side effects such as: bloody or watery diarrhea. , painful or difficult urination, urgent need to urinate or blood in the urine, thirst, dry mouth, confusion, muscle pain or weakness, frequent urination, rapid heart rate,..
Patient recommendations If you experience any symptoms of hypersensitivity, you should tell your doctor and stop using Combikit immediately.
When a patient has a serious anaphylactic reaction that requires immediate emergency treatment, this will be done by a doctor or medical staff: subcutaneous injection of the indicated dose of adrenaline, intravenous corticosteroids, oxygen breathing respiratory support. When bleeding occurs, the drug should be stopped immediately and appropriate treatment indicated.
4. Drug interactions
Do not use Combikit with anticoagulants because it may increase the risk of bleeding. The risk of Combikit side effects is increased when taken with Probenecid. Do not use with Tetracycline group of antibiotics such as Doxycycline because it reduces the effect of Combikit. Methotrexate side effects are increased when taken with Combikit. The effectiveness of the following drugs may be reduced when used with Combikit: Mycophenolate, Aminoglycoside antibiotics such as Gentamycin or oral contraceptives. Combikit may cause a false-positive Coombs reaction.
5. Pay attention to using Combikit
Do not use Combikit for pregnant women, only use it when absolutely necessary under the supervision of a doctor, the treatment benefits outweigh the possible side effects. Breastfeeding women can use Combikit but should be cautious. Use with caution in subjects with severe liver dysfunction, moderate and severe renal impairment. Do not use Combikit when the expiry date printed on the package has expired or there are signs of lumps or discoloration. Store the medicine in a cool place, away from direct sunlight, the appropriate temperature is below 25°C. Keep out of reach of children.
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