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Cobicistat, also known by its common name Tybost, is a prescription medication that has been approved by the Food and Drug Administration (FDA) for use in the treatment of immunodeficiency virus infections. in humans (HIV) in both adults and children.1. Cobicistat drug effect
Cobicistat is indicated for use in the following cases:
Cobicistat is used in combination with Atazanavir (Reyataz) or Darunavir (Prezista) to treat human immunodeficiency virus (HIV) or viruses that can cause syndrome acquired immunodeficiency syndrome (AIDS). Mechanism of action: Cobicistat does not have any activity against HIV but is used only as a pharmacokinetic enhancer to boost the action of other HIV drugs.
2. Dosage and usage
How to use: Cobicistat comes in tablet form and each tablet contains 150mg of Cobicistat. Patients use Cobicistat by mouth, after eating or during meals, once a day.
Drug dosage:
Need to follow the doctor's instructions. Patients can refer to the dose of 1 tablet per day. When used in combination with Atazanavir, Cobicistat is used for adults and children weighing at least 35 kg or more. When taken with Darunavir, Cobicistat is FDA-approved for use in adults and children weighing at least 40 kg or more. Note: Cobicistat is not a treatment for HIV. Even if you take Cobicistat in combination with Atazanavir or Darunavir, you will need to take other HIV medicines prescribed by your doctor. Therefore, patients should not voluntarily cut back, skip or stop taking Cobicistat or any HIV medication unless directed by their doctor.
Missed dose:
If the patient misses a dose of Cobicistat, take the dose as soon as you remember. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the usual time. Do not take 2 doses at the same time to make up for a missed dose. The drug is contraindicated in case:
The patient is allergic to Cobicistat, Atazanavir, Darunavir or any other drugs. Patients have problems with impaired kidney function and impaired liver function. If the patient is pregnant and breast-feeding: For HIV-infected women who are pregnant, doctors recommend not using Cobicistat. Women who are breast-feeding should consult their doctor before taking the drug and if necessary, seek a more suitable alternative treatment. If you are using birth control based on changing your hormone levels (such as the pill, implant or vaginal ring), Cobicistat may make these methods less effective. more effective.
3. Side effects
Cobicistat may cause side effects such as nausea, vomiting or a feeling of dizziness. However, these side effects are manageable and do not have a major impact on the patient's health.
When Cobicistat is taken with Atazanavir, the most common side effects include jaundice or rash.
Some signs of an allergic reaction include: hives, difficulty breathing; swelling of the face, lips, tongue, or throat.
Cobicistat can cause serious side effects such as kidney problems: Urinating little or no, swelling feet or ankles, feeling tired or having liver problems such as: Upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice or yellow eyes.
If experiencing these symptoms, the patient should stop using Cobicistat and notify the doctor for appropriate treatment.
4. Caution
If you take antacids, take them at least 2 hours before or 2 hours after the person takes cobicistat and atazanavir.
If the patient is taking medicines for stomach ailments such as: Cimetidine, Ranitidine, Tagamet, Axid, Zantac, Pepcid, etc., they should wait at least 10 hours after taking these drugs before taking the dose of cobicistat and Atazanavir.
If the patient is taking a proton pump inhibitor such as: Omeprazole, Esomeprazole, Nexium, Prevacid, Prilosec, Protonix, wait at least 12 hours before taking the dose of Cobicistat and Atazanavir.
Do not use Cobicistat if the drug shows signs of unsatisfactory quality.
Keep Cobicistat out of reach of children
5. Drug interactions
Inform your doctor about other prescription and over-the-counter medicines, vitamins, nutritional supplements and herbal products that you are taking or plan to take. Cobicistat with other products may cause drug interactions, affect effectiveness, or increase side effects. Taking Cobicistat together with Atazanavir or Darunavir and certain other medicines can cause serious or life-threatening side effects. 1,2-Benzodiazepine, Abatacept, abemaciclib: The metabolism of these drugs may be reduced when combined with Cobicistat. Abametapir: The serum concentration of Cobicistat can be increased when it is combined with Abametapir. Acenocoumarol: The serum concentration of Acenocoumarol can be increased when it is combined with Cobicistat. Allopurinol: Cobicistat may decrease the rate of excretion of Allopurinol, which may lead to higher serum concentrations. Antipsychotics such as Lurasidone and Pimozide : Increases unwanted side effects. Alpelisib: The serum concentration of Alpelisib may be increased when it is combined with Cobicistat. To avoid interactions, before being prescribed Cobicistat, patients should inform their doctors about all the drugs they are using, including dietary supplements. The doctor will base on that to prescribe the appropriate Cobicistat.
Above is all information about Cobicistat, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Cobicistat is a prescription drug, patients absolutely must not buy and treat at home because they may experience unwanted side effects.
