Uses of Clovagine

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1. What effect does Clovagine have?

What is clovagine? Clovagine belongs to the group of gynecological drugs with the main ingredient being clotrimazol with a strength of 100mg. In which, clotrimazol is a synthetic derivative of imidazole with similar chemical structure to miconazole. The drug has broad-spectrum antifungal action, capable of inhibiting the growth of most human pathogenic fungi such as dermatophytes, malassezia furfur and yeasts, trichomonas, staphylococcus, bacteroides and is not active against lactobacillus.
The mechanism of action of clotrimazol is to bind to phospholipids in the fungal cell membrane, helping to change the permeability of the membrane and cause the loss of essential intracellular substances leading to the destruction of the fungal cell. Clovagine is inhibitory and fungicidal depending on the concentration and strains such as trichophyton mentagrophytes, epidermophyton fl oc-cosum, mycrosporum canis and other candida species. Natural resistance to clotrimazole is rare. Only one strain of Candida gulliermondi resistant to clotrimazol was isolated. Cross-resistance between azoles is common. The drug has a local therapeutic effect on cases of vaginitis of various etiologies.

2. Indications and contraindications to the drug Clovagine

2.1 Indications for use of C lovaginin Indications to use Clovagine in the following cases:
Mixed bacterial infections in the vagina Vaginitis accompanied by white discharge Itching due to bacterial and fungal infections Trichomonas vaginitis Vaginitis Vaginal, vulvar, candidiasis In addition to the above uses, clovagine may also be used to treat some other conditions that are not listed above. Therefore, patients should consult with their doctor before taking the drug for advice on how to use the drug effectively.
2.2 Contraindications to the use of clovagine The use of clovagine is contraindicated in cases where the patient has a history of allergy, hypersensitivity to any ingredient of the drug.

3. How to use and dosage of Clovagine

Clovagine is in the form of a vaginal capsule. Before using the medicine, put the tablet in the freezer for about 5-10 minutes and wash the vagina. Then put the pill deep inside the vagina every night before going to bed, note that placing as deep as possible will bring high treatment effect. Dosage of clovagine drug will depend on the disease condition, as well as the age of the patient such as:
For acute vaginitis: use a dose of 1 tablet (100mg)/time, 1-2 times a day. (morning and evening), after 1 tablet in the evening, treatment within 6-8 days. Then maintain 1 capsule in the evening for the next 6-8 days. For chronic vaginitis: 1 tablet in the evening, treatment for 14 days. Use Clovagine regularly to get the most benefit from it. To use it safely, take clovagine exactly as directed by your doctor, do not use more, smaller doses or for longer than prescribed. Absolutely do not arbitrarily increase the dose of the drug or abuse the drug for too long for a long time. Because this not only makes your condition worse, but also increases the risk of unwanted effects.

4. Undesirable effects when using Clovagine

Some unwanted effects that may occur when using clovagine include:
Mild burning Irritation Vaginal burning Before prescribing the drug, the doctor always considers the benefits and effectiveness of clovagine. greater risk of side effects. However, some cases when using clovagine can still occur unwanted effects. Therefore, when there are unusual signs after taking the drug, especially when a severe allergic reaction is accompanied by signs such as severe dizziness, difficulty breathing, swelling of the face, throat and tongue, rash or itching,... In this case, the patient or family member should immediately notify the medical staff for immediate treatment.

5. Some notes when using Clovagine

Some notes when using clovagine include:
Inform your doctor about any history of hypersensitivity, allergy to clovagine or any other allergies. Clovagine may contain inactive ingredients and could cause an allergic reaction or other serious problems. Report any medications you are taking including prescription and over-the-counter medicines, herbs and supplements, foods, preservatives or dyes. Avoid sex during treatment, to prevent re-infection of your partner. Take clovagine for a full period of time even if symptoms have resolved. After 4 weeks of using the drug without any effect, it is necessary to re-examine. Avoiding sources of infection and reinfection Clovagine may reduce the reliability of mechanical contraceptives such as condoms and diaphragms due to the interaction of the suppository and the condom. Clovagine should be used with caution in pregnant and lactating women. If you forget to take a dose, take the missed dose as soon as possible. However, if the time of remembering is close to the time of the next dose, skip the missed dose and continue taking the medicine as scheduled. Do not arbitrarily use the drug twice the dose more than the treatment regimen. Overdose with clovagine can cause serious symptoms such as leukopenia, peripheral sensory neuropathy, nausea, vomiting, abdominal pain, asthenia, ...

6. Drug interactions

Drug interactions can decrease the effect of clovagine, or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including vitamins, prescription drugs, over-the-counter medicines, and other herbal products. Do not stop, start, or change the dose of any medicine without your doctor's consent.
Currently there is not enough information on the synergistic or antagonistic effects of clotrimazol with C.Albicans, nystatin, amphotericin B, flucytosin. In the serum of liver transplant patients, tacrolimus concentrations are increased when co-administered with clotrimazol. Therefore, it is necessary to reduce the dose of the drug according to the need.

7. How to store clovagine?

Store clovagine at room temperature, away from light and away from moisture. Do not store clovagine in a humid place or in the freezer. Different medicines will have different storage methods, so read the clovagine storage instructions on the package carefully, or ask your pharmacist. Keep clovagine out of the reach of children and family pets. When the medicine has expired or has been damaged and cannot be used anymore, dispose of the medicine according to the correct procedure. Do not arbitrarily dispose of clovagine into the environment such as plumbing or toilet unless requested. Consult with your environmental company or pharmacist on how to safely dispose of clovagine to help protect the environment.
In summary, clovagine belongs to the group of gynecological drugs indicated in the treatment of mixed vaginal infections, itching caused by bacterial and fungal infections, vaginitis, treatment of fungal infections,... However, Clovagine can cause some unwanted effects and drug interactions, so tell your doctor what medicines you are taking to reduce the risk of unwanted effects and at the same time make them more effective. treatment process.
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