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Cedazuridine and Decitabine is a combination medicine used to treat certain blood and bone marrow disorders, such as myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). So what is Cedazuridine and Decitabine? How does the drug work? Read the article below to be able to answer the above question.
1. What is Cedazuridine and Decitabine?
Cedazuridine and Decitabine are sold under the brand name Inqovi. This is a combination medicine used to treat adults with myeloproliferative disorders (MDS) and chronic myelomonocytic leukemia (CMML).
In which:
Decitabine (content 35mg) is an inhibitor of Nucleoside metabolism; Cedazuridine (100mg strength) is a Cytidine deaminase inhibitor.
2. Instructions on how to take Cedazuridine and Decitabine
To use Cedazuridine and Decitabine, users need to follow the instructions on the drug label and the doctor's instructions. Usually this combination drug will be prescribed for 1 treatment cycle of 28 days. Users take 1 tablet / day for the first 5 days of each cycle, then the doctor will determine the next specific treatment time depending on the patient's response.
Notes when taking Cedazuridine and Decitabine:
Take the medicine on an empty stomach (at least 2 hours before or after a meal); Take the above combination at the same time every day; Swallow the tablet whole without crushing, separating, or breaking the tablet; Do not stop taking the medicine or change the dose on your own without consulting your doctor. If you vomit right after taking Cedazuridine and Decitabine, do not take another dose right away but wait until the time for your next dose. In addition, to help limit nausea or vomiting, your doctor may help you prescribe other medications.
3. Side effects of drugs Cedazuridine and Decitabine
During treatment with Cedazuridine and Decitabine, this medicine can affect your immune system and cause some side effects such as:
Fever, headache, dizziness, fatigue, trouble breathing, cold hands and feet; Abnormal liver function tests; Swelling in the hands or feet; Muscle pain, joint pain; Sore mouth due to sores; Nausea, loss of appetite; Diarrhea or constipation; Contact your doctor soon if you experience more serious side effects such as:
Low blood cell counts (red blood cells, white blood cells, platelets) which can increase the risk of infection, bleeding; easy bruising or bleeding, purple red spots under the skin; Occurrence of allergic reactions such as: rash, itching, swelling of the face, lips, tongue; Fever or cold symptoms: sneezing, cough, stuffy nose, sore throat; Shortness of breath, cough with mucus, lung infection; To ensure safety during treatment, the use of Cedazuridine and Decitabine may be considered adjusted or permanently discontinued if the user experiences certain side effects.
4. Notes when using Cedazuridine and Decitabine drugs
Before taking Cedazuridine and Decitabine, tell your doctor if you have ever:
Have kidney disease, impaired kidney function; Hypersensitivity to the active substance or to any of the excipients (especially Cedazuridine, Decitabine); Have liver disease, impaired liver function; Are pregnant or suspect to be pregnant. Be especially aware that Cedazuridine and Decitabine can harm an unborn baby or cause birth defects if the mother or the father's fertility is being treated with this medicine. Therefore:
If you are a woman, do not take Cedazuridine and Decitabine during pregnancy. You may be asked to have a negative pregnancy test if you decide to take the pill. In addition, effective contraception should be used while taking the drug and for at least 6 months from the last dose; If you are a man, if you are taking medication, you should actively use birth control when having sex with your partner. Maintain avoidance measures for at least 3 months from the last dose. Similarly, women who are breastfeeding should also not take Cedazuridine and Decitabine for at least 2 weeks after the last dose.
Cedazuridine and Decitabine are also not recommended for use by people under 18 years of age.
5. Interactions of Cedazuridine and Decitabine
Cedazuridine and Decitabine are metabolized by Cytidine Deaminase (CDA). Therefore, co-administration with drugs metabolized by CDA may lead to increased systemic exposure and increased toxicity of these drugs. Therefore, the co-administration of Cedazuridine and Decitabine with drugs metabolized by CDA should be avoided.
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