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Cebastin 20 is a drug that is taken orally, belongs to the group of prescription drugs - ETC (medicine sold by prescription). The drug is prepared in the form of film-coated tablets with a box format of 3 blisters x 10 tablets (30 tablets/box) or 6 blisters x 10 tablets (60 tablets/box). So what is Cebastin 20?
1. What is Cebastin 20?
Cebasin 20 of the medicinal product of 3/2 Pharmaceutical Joint Stock Company. The main ingredient of Cebasin 20 is Ebastin with a content of 20mg and excipient system includes: Microcrystalline Cellulose, Starch 1500, Croscarmellose Sodium, Magnesium stearate, Lactose Monohydrate, ReadiLYCOAT, purified water...
Ebastin is an antagonist to histamine at the H1 receptor, this active ingredient is long-acting and selective. After oral administration, Ebastin will be rapidly absorbed and converted into Carebasin - this substance will give pharmacological activity. After a single oral dose of Cebasin 20 containing Ebastin 20 mg, peak plasma concentrations of Ebastin were 2.8 ng/ml in 1-3 hours and of Carebasin 157 ng/ml. The half-life of the metabolite Carebasin is 15-19 hours, and 66% of Carebastin will be eliminated primarily in the urine as a conjugated metabolite.
2. Uses of the drug Cebastine 20
Cebastin 20 is indicated for use in the following cases:
Treatment of allergic rhinitis (seasonal allergic rhinitis or perennial allergic rhinitis), with or without allergic conjunctivitis ; Treatment of chronic idiopathic urticaria.
3. Dosage of Cebastine 20
Take the whole Cebastin 20 tablet with a glass of water, can be taken with or without food with the following dosage:
Patients with severe itching: Initially 20mg/day (1 Cebastin 20 tablet), then 10mg/day when itching has subsided; Treatment of seasonal allergic rhinitis: 20mg/day; For people with mild to moderate hepatic impairment: only use up to 10 mg/day. Note: The dosage of Cebastin 20 is for reference only, the specific dose may change depending on the condition and progress of each specific patient, so to have a suitable dose of Cebastin 20. In case, the patient should consult a doctor.
4. What to do when overdose of Cebasin 20?
In studies conducted with a high dose of Cebastin 20, there were no clinically significant signs or symptoms when tested up to 100 mg once daily. There is currently no specific antidote for Ebastin.
In case of overdose of Cebastin 20, it is necessary to perform gastric lavage, monitor vital functions including electrocardiogram, and actively treat symptoms if present.
5. Side effects of Cebastine 20
When using Cebasin 20, patients may experience unwanted effects. Side effects of Cebastin 20 are usually: headache, dry mouth, drowsiness. Rarely, pharyngitis, abdominal pain, dyspepsia, fatigue, epistaxis, rhinitis, sinusitis, nausea, insomnia. The side effects of Cebastin 20 can be mitigated by reducing the dose. When experiencing side effects of Cebastin 20, patients should stop using the drug and immediately notify the doctor or quickly go to the nearest medical facility for timely treatment.
6. Contraindications of Cebastine 20
Cebastin 20 is contraindicated for use in patients with hypersensitivity to the components of Cebasin 20.
7. Be careful when using Cebastine 20
Cebastin 20 should be used with caution in patients with long QT syndrome, hypokalemia, patients being treated with drugs capable of increasing QT or inhibiting the CYP3A4 enzyme system (azole antifungals, macrolide antibiotics ) ; Ebastin should also be used with caution in patients with mild to moderate renal or hepatic impairment. Cebastine 20 should not be used by pregnant or nursing women. Cebastine 20 should be avoided when driving and operating machinery because it can cause headaches and drowsiness.
8. Drug interactions of Cebastine 20
Cebastin 20 may interact with other H1 antihistamines, antiarrhythmics, azole antifungals and macrolide antibiotics. Do not take Cebastin 20 with alcohol. Store Cebasin 20 in a cool place, away from light, at a temperature below 300C and keep Cebastin 20 out of the reach of children. Cebastine 20 is only used under the prescription of a doctor.
Cebastin 20 is a drug that is taken orally, belongs to the group of prescription drugs - ETC (medicine sold by prescription). The drug is prepared in the form of film-coated tablets with a box format of 3 blisters x 10 tablets (30 tablets/box) or 6 blisters x 10 tablets (60 tablets/box). To ensure the effectiveness of treatment and avoid side effects, patients need to take the drug exactly as directed by the doctor, professional pharmacist.
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