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Cbimigraine is indicated for the prevention of migraine headaches. However, this drug has some adverse effects such as extrapyramidal syndrome, depression. So when using Cbimigraine, what should be noted to be effective and safe? Let's learn about the drug Cbimigraine in this article.
1. What is Cbimigraine?
Cbimigraine is made in the form of hard capsules with the active ingredient Flunarizine dihydrochloride 5.9 mg, equivalent to Flunarizine 5 mg.
Flunarizine has antihistamine, calcium channel blocker and sedative activity. The drug prevents intracellular calcium overload by reducing excessive transmembrane calcium flux. However, flunarizine does not inhibit the normal homeostasis of intracellular calcium.
Flunarizine has the ability to reduce the frequency and severity of migraine attacks but does not affect the duration of the attacks.
In addition, flunarizine has no effect on myocardial contractility, does not inhibit the sinoatrial or atrioventricular node, does not increase heart rate, has no antihypertensive effect.
2. Indications of the drug Cbimigraine
Cbimigraine is indicated in the prevention of migraine headaches. However, Cbimigraine should not be used in patients with a history of hypersensitivity to any of its components.
3. Dosage and usage of Cbimigraine
Cbimigraine should be taken in the evening. The usual dose for children over 12 years of age and adults is 10mg/day. Patients who experience undesirable effects can reduce the dose to 5mg/day.
4. Undesirable effects of the drug Cbimigraine
When using Cbimigraine, patients may experience the following undesirable effects:
Common undesirable effects (frequency of ADR > 1/100): fatigue, drowsiness, weight gain... Effects Uncommon (incidence 1/1000 < ADR < 1/100): depression, extrapyramidal symptoms (restlessness, slow movement, rigidity, dyskinesia, tremor), dry mouth.. Rare adverse effects (ADR frequency < 1/1000): stomach pain, nausea, increased lactation
5. Notes when using Cbimigraine
When using Cbimigraine, it is necessary to pay attention to the following issues:
During treatment, it is necessary to closely monitor the patient to detect extrapyramidal symptoms early (common symptoms such as slow movement, facial paralysis, etc.) , convulsions, restlessness, episodic tremor, tremor, palpitations) or depression, if necessary discontinue treatment. In the case of severe extrapyramidal symptoms, appropriate supportive therapy such as Parkinson's disease medication may be used. Patients with a history of extrapyramidal symptoms should be closely monitored as they may have difficulty performing daily activities such as changing clothes, going up and down stairs, etc. Dose response should be checked after 2 days. months from starting Cbimigraine. Thereafter, periodic check-ups should be made to decide whether to discontinue or to discontinue the drug. If no response, treatment should be discontinued. If a response cannot be determined, the drug should be withheld. Depending on the severity of symptoms, a decision is made to stop or continue taking the drug. Patients may have abnormalities in liver function such as elevations in liver enzymes (ALT, AST, ALP, LDH) and should be monitored closely, if these abnormalities occur, treatment with Cbimigraine should be discontinued. Cbimigraine should be used with caution in elderly patients, patients with impaired liver function There have been reports of fetal abnormalities such as bone disorders in rat studies, so Cbimigraine is contraindicated during pregnancy. pregnant. Cbimigraine should not be used in lactating women, if necessary, breast-feeding should be discontinued. Cbimigraine has sedative and/or somnolence effects, so this medicine is not suitable for patients to drive or operate machinery Overdose of Cbimigraine can cause agitation, tachycardia, sedation. In this case, it is necessary to use supportive measures such as gastric lavage, if necessary, use activated charcoal.
6. Drug interactions
Drugs with Cbimigraine interact with the following drugs:
Alcohol, sleeping pills, sedatives used together with Cbimigraine drugs increase the sedative effect. Medications to treat high blood pressure : Cbimigraine may increase the antihypertensive effect of these drugs. However, Cbimigraine is not contraindicated in patients taking beta-blockers.
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