Uses of Carbatol 200

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1. What is Carbatol 200?

Carbatol 200 contains the main active ingredient, Carbamazepine, 200mg, excipients just enough, belongs to the group of psychotropic drugs, prepared in the form of tablets, packed in a box of 10 blisters (1 blister of 10 tablets).

2. Uses of Carbatol 200

2.1.Indications of Carbatol 200 Used in epilepsy: partial seizures with complex symptoms such as temporal lobe epilepsy, psychomotor epilepsy. Carbatol 200 is used for acute manic episodes and as a maintenance treatment for bipolar affective disorders to prevent and reduce the likelihood of recurrence. Treatment of subjects with alcohol withdrawal syndrome. Use Carbatol 200 to treat idiopathic or multiple sclerosis-induced trigeminal neuralgia. Carbatol 200 is also used to treat neuropathy caused by diabetes, polyuria and polyuria of neurohormonal origin, central diabetes insipidus. 2.2. Contraindications of the drug Carbatol 200 Contraindicated for use in subjects with hypersensitivity to the active substance Carbamazepine and tricyclic antidepressants. For patients with myelosuppression is not indicated. If the patient is being treated with an MAOI, an MAOI must be discontinued for at least 14 days. Carbatol 200 should not be combined with an MAOI.

3. Dosage and how to use Carbatol 200

3.1. Administration: Treatment with Carbatol 200 should be started at a low dose, then gradually increased until maximum effect is achieved. Once seizures are well controlled, the lowest effective dose can be reduced.
If Carbatol 200 is to be used as an adjunct to another epilepsy drug, Carbatol 200 must be introduced gradually during maintenance, or the dosage of the other epilepsy drug should be adjusted.
3.2. Dosage For adults: Treatment should be started with a dose of 100-200 mg, 1-2 times a day. The dose is gradually increased to the maximum response dose, usually 400 mg, 2 to 3 times a day. Depending on the individual patient, the indicated dose can range from 1600mg or 2000mg per day. For children: dose from 10 to 20mg/kg body weight/day For children under 1 year old: 100-200mg/day (equivalent to 1⁄2 - 1 Carbatol 200 tablet) : dose 200-400 mg/day (equivalent to 1-2 Carbatol 200 tablets) Children from 6 to 10 years old: 400-600 mg dose (equivalent to 2-3 Carbatol 200 tablets) Children from 11 to 15 years old: dose 600-1000 mg/day (equivalent to 3 - 5 Carbatol 200 tablets) In children 4 years of age or younger, treatment should only be started with an initial dose of 20-60 mg/day, then increased to 20- 60 mg/day. 60 mg per day. For children older than 4 years, start with a therapeutic dose of 100 mg/day then increase to 100 mg weekly. When replacing Carbatol 200 oral tablets with suppositories, the dose used should be increased by 25% compared to the above level, the maximum dose when using suppositories should not exceed 1000mg. For patients with nerve pain V: use with a starting dose of 200 to 400mg (equivalent to 1-2 Carbatol 200 tablets)/day. Indication to increase the dose slowly until the pain is gone is usually 200mg (1 tablet) 3 to 4 times a day. Once a therapeutic effect has been achieved, the dose should be reduced to the maintenance dose level. For the elderly can apply the dose starting from 100mg, twice a day. Dosage of Carbatol 200 for alcohol withdrawal syndrome: the average dose is 1 tablet of 200mg, 3-4 times a day. In severe cases, the dose should be increased at the beginning (400mg, 3 times a day) and Tegretol must be combined with other insomnia/sedative drugs such as cholordiazepoxide, clomethiazole. Tegretol is still indicated for continued use as monotherapy after the acute phase has passed. For the prevention of bipolar state, manic episodes: the recommended dose is high from 400 to 1600 mg used in 1 day. Dose escalation will be different for the two cases above, in acute manic episodes need to increase the dose quickly, and in the prevention of bipolar state, increase the dose slightly to achieve the best tolerability. It should be noted: The above drug dosage is for reference only, users need to strictly follow the doctor's instructions to ensure the best treatment effect.
3.3. Treatment of Carbatol 200 overdose Signs : When using Carbatol 200 overdose, patients often experience manifestations of central nervous system, respiratory tract and cardiovascular system. Specifically;
Central nervous system: disorientation, hallucinations, agitation, neurasthenia, somnolence, coma, dysarthria, slurred speech, color blindness, nystagmus, psychomotor disturbances, hypotension body temperature, myoclonus, convulsions, before increased reflexes, then decreased reflexes. Respiratory tract: pulmonary edema, respiratory depression Circulatory system: hypotension, tachycardia, sometimes increased blood pressure. Syncope with cardiac arrest, QRS complex disorder. Digestive system: Decreased intestinal motility, slow gastric secretion, vomiting. Urinary – Genitourinary: oliguria, urinary retention, water intoxication similar to the effect of ADH, water retention. Laboratory tests showed: metabolic acidosis, hyponatremia, increased muscle creatinine phosphokinase, hyperglycemia. Treatment of Carbatol 200 Overdose There is currently no specific antidote for Carbatol 200 overdose The initial management should depend on the patient's condition: after referral to the hospital for confirmation. blood level determination to verify carbamazepine toxicity and the extent of the patient's overdose. Use activated charcoal and suction, gastric lavage. Besides, it is necessary to monitor and take special care of the patient. Some specific treatment guidelines for each symptom:
Hypotension: Dobutamine or dopamine IV Convulsions: use antiepileptic drugs such as phenobarbital, benzodiazepine (diazepam), paraldehyde. Hyponatremia: slow infusion, limit water intake, be cautious with 0.9% NaCl solution intravenously. In some patients, slow absorption of Carbatol 200 may occur. Therefore, it should be noted that symptoms may appear on the 2nd or 3rd day.

4. Undesirable effects of the drug Carbatol 200

Side effects when taking Carbatol 200 include signs of gastrointestinal disorders (vomiting, nausea), neurological disorders (drowsiness, headache, dizziness, ataxia, diplopia, fatigue), skin and skin appendages (urticaria, skin allergy), blood (thrombocytopenia, leukopenia, sometimes eosinophilia), liver (elevated alkaline phosphatase, increased g-GT), endocrine system and metabolism (water retention, weight gain, edema, hyponatremia, and hypovolemia). Other rare reactions such as: nystagmus, involuntary movements (oral-facial dyskinesia, dystonia, dystonia, tremor, myoclonus), systemic lupus erythematosus syndrome, erythema, exfoliative dermatitis, Stevens-Johnson syndrome, lymphadenopathy, leukocytosis, cardiac arrhythmia, etc. Most of the side effects are dose related and will be spontaneous. decrease in a few days when the dose is reduced.

5. Pay attention when using Carbatol 200

While using Carbatol 200, it is necessary to note some of the following issues:
Advise patients to be careful when driving, operating machinery or doing work that requires alertness because Carbatol 200 can cause Decreased concentration, dizziness and drowsiness. For pregnant women: There has been a lot of evidence of fetal malformations or teratogenicity when Carbatol 200 is used during the first 3 months of pregnancy. However, if not treated to control seizures increases the risk to both mother and baby, caution and consideration should be taken when administering epilepsy treatment during pregnancy. The active ingredient Carbamazepine in Carbatol 200 accumulates in breast milk. However, the risk of breastfeeding is low, the baby needs to be monitored to avoid unwanted complications. Carbatol 200 is manufactured and registered by Torrent Pharmaceuticals Ltd. The drug is indicated for the treatment of epilepsy and some other neurological diseases, patients need to strictly follow the doctor's instructions to ensure the highest effectiveness.
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