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Caplexib is one of the non-steroidal anti-inflammatory drugs (NSAIDs) known for its ability to relieve pain caused by osteoarthritis or in acute pain after surgery, tooth extraction. Learn more about the uses and uses of this drug to help patients use it more effectively.
1. What is Caplexib?
Caplexib medicine contains the main ingredient is Celecoxib 200 mg. This is an active ingredient in the group of pain relievers, non-steroidal anti-inflammatory drugs (NSAIDs). The mechanism of action of Celecoxib is to selectively inhibit the enzyme Cyclooxygenase 2 (COX-2) - an enzyme that responds to inflammatory agents. From here, Caplexib helps promote effectiveness in preventing the synthesis of Prostaglandin E2, the leading cause of inflammation, pain, swelling and edema.
Because Caplexib does not have a mechanism of action on the COX-1 enzyme, from here all physiological processes related to this enzyme in the gastric mucosa, intestines, and platelets are not affected. As such, this means that Celecoxib does not cause as many unwanted effects as some COX-1 inhibitors.
2. Indications and contraindications to the drug Caplexib
2.1. Indications With the above effect, Caplexib is often prescribed by doctors in the following cases:
Patients with arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis Women with menstrual pain during menstruation terrible. Caplexib can be used in the treatment of hereditary polyps in the colon. In some cases, your doctor may prescribe Caplexib to treat gout. 2.2. Contraindications Caplexib is contraindicated in the following cases:
People who are hypersensitive or sensitive to the Celecoxib component in the drug. People with a history of allergy to Sulfamide, asthma, urticaria, allergic reaction to Aspirin and other active ingredients of the NSAID group. Celecoxib is not recommended for people with severe heart/kidney/liver failure, inflammatory bowel disease (Crohn's disease, ulcerative colitis), pregnancy/breastfeeding.
3. Dosage and usage
Using Caplexib for people with chronic osteoarthritis: 200mg/day, once or divided into 2 times. Patients with rheumatoid arthritis: Use a dose of 200mg x 2 times / day. In the case of drug use to control acute pain and treat dysmenorrhea, patients should take Caplexib at an initial dose of 400 mg, supplemented with 200 mg if needed on the first day of use. Then in the following days, use the drug at a dose of 200mg x 2 times / day if necessary, paying attention to the interval between doses at least 4 hours.
Caplexib is a drug that is taken orally, you can take it on an empty or full stomach.
4. Caplexib . drug side effects
Caplexib has a risk of causing some side effects such as:
Headache, dizziness, abdominal pain, nausea, vomiting, diarrhea, flatulence. Bleeding from the upper gastrointestinal tract or causing an upper gastrointestinal infection. Bronchitis , severe cough, pharyngitis, rhinitis, sinusitis, Joint pain, back pain or muscle pain in some places. There is a feeling of itching, peripheral edema, rash on the skin.
5. Caplexib drug interactions
Caplexib can interact with some drugs such as Warfarin, Fluconazole, Furosemide.... Therefore, in case the 2 drugs are prescribed together, the doctor can change the dosage or frequency of Caplexib to avoid interactions.
6. Precautions while taking Caplexib
Caution in using Caplexib for the following subjects:
Patients with a history of cardiovascular diseases, heart failure because Caplexib has an increased risk of thromboembolism, myocardial infarction, making patients more susceptible to heart failure. stroke, hypertension or cardiac edema. Patients with signs of liver dysfunction, with abnormalities in liver function tests should be cautious when taking the drug. Patients with a history of peptic ulcer disease, especially in the elderly, require dose adjustment. People with kidney failure, dehydration or electrolyte disturbances, taking oral anticoagulants should consult their doctor carefully before taking the drug. Caplexib will work best when used correctly and in the right dose. Therefore, you need to carefully read the instructions for use, consult your doctor before use.
