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Canzeal 4mg is a drug that helps lower blood sugar, used for patients with non-insulin dependent diabetes. When using drugs to be able to use drugs safely, it is necessary to understand the drug and pay attention when using it.
1. What is Canzeal 4mg?
The main ingredient of Canzeal 4mg is Glimepiride and excipients just enough for one tablet. Glimepiride is an oral antidiabetic drug of the sulphonylurea group. It is used to treat people with non-insulin dependent diabetes. Glimepiride works primarily by stimulating the release of insulin from the beta cells of the pancreas. As with other sulphonylureas, this effect is due to an increased response of pancreatic beta cells to physiological glucose stimulation.
Thanks to the effect of stimulating insulin secretion, so sometimes the drug can cause hypoglycaemia side effects when taken.
2. Indications and contraindications of Canzeal 4mg
Indications:
Canzeal 4mg is indicated for use in: Treatment of type 2 diabetes when the patient is applying measures such as strict adherence to the diet, weight loss in case of excess obesity. weight, exercise without the desired results. Using the drug still requires a combination of the above measures to increase effectiveness.
Contraindications:
Canzeal 4mg is contraindicated in the following cases:
Hypersensitivity to the active glimepiride, sulphonylureas or sulphonamides or any of the excipients of the drug. Insulin-dependent diabetes mellitus. Diabetic coma. Metabolic ketoacidosis. Severe liver or kidney dysfunction. This drug should not be used in patients with lactose intolerance.
3. Dosage and usage of Canzeal 4mg
Usage: The drug is taken orally. Take with water and need to take the medicine before meals.
Dosage: The drug is prescribed depending on the response of each patient. Below you can refer to drug dosage and drug combination.
The starting dose is 1mg glimepiride/day. If good results are achieved, this treatment dose should be maintained. If the desired effect is not achieved, the dose should be increased, with an interval of 1 to 2 weeks to doses of 2, 3, or 4 mg of glimepiride per day. Doses greater than 4 mg/day are only more effective in rare cases. The maximum dose of the drug is 6mg/day. If the patient still does not respond adequately to the maximum dose of metformin, combination therapy with glimepiride may be considered: During maintenance dosing with metformin, add glimepiride at the lowest starting dose and titrate based on response. patient response. If the patient still does not respond adequately to glimepiride at the maximum daily dose, insulin can be added. If a patient has a hypoglycemic reaction when taking a dose of 1mg glimepiride per day, it indicates that the patient can usually control blood sugar with diet alone. In order to avoid excessive hypoglycaemia, the possibility of dose reduction or discontinuation should be considered.
Overdose and missed dose:
Overdose: After taking an overdose, hypoglycemia may occur due to overdose, lasting from 12 to 72 hours and may recur after initial recovery. At this point, the patient needs to be taken to the hospital to be examined by a doctor. Missed dose: If you forget to take a dose, do not increase the next dose to make up for it. Try not to miss a dose for the best blood sugar lowering effect.
4. Undesirable effects of Canzeal 4mg
When using Canzeal 4mg, you may experience unwanted effects, including:
Common: Transient visual disturbances, this symptom usually occurs at the beginning of treatment due to changes in blood sugar levels. Rare: Thrombocytopenia, leukopenia, decreased red blood cell count, granulocytopenia, agranulocytosis, hemolytic anemia, pancytopenia. ; Hypoglycemia. Very rare: Allergic vasculitis; Mild to severe hypersensitivity reactions including dyspnea, hypotension and sometimes shock. Possible cross-allergy to sulphonamides or related active ingredients. Gastrointestinal symptoms such as nausea and vomiting, diarrhea, gastric distension or distention, and abdominal pain are rarely sufficient to warrant discontinuation of the drug. Increased liver enzymes, decreased liver function, hepatitis and liver failure. Skin sensitization reactions such as pruritus, rash, urticaria and photosensitivity. Decreased serum sodium concentration. When experiencing side effects of the drug, it is necessary to stop using the drug and notify the doctor or immediately go to the nearest medical facility for timely treatment.
5. Notes of Canzeal 4mg
The drug is used under a doctor's prescription, before using it, it is necessary to inform the doctor about the history of allergies and medical history if any. Read the medication instructions carefully before use.
Glimepiride must be taken immediately before meals, because to reduce blood sugar after eating. When eating at the wrong time or when skipping meals can lead to hypoglycemia when taking glimepiride.
Treatment with sulphonylureas in patients with G6PD deficiency can cause hemolytic anemia. Therefore, caution should be exercised in patients with G6PD deficiency and alternative drug classes should be considered. Liver function, blood count, blood glucose levels, urinary glucose, and HbA1c should be checked periodically.
Patients should take care to avoid hypoglycemia while driving or operating machinery. This is especially important when the patient has reduced or masked hypoglycaemia warning symptoms or the patient has frequent episodes of hypoglycaemia, in which case consideration should be given to driving a vehicle or operating machinery.
Pregnancy : There are not enough data on the use of glimepiride in pregnant women. Therefore, glimepiride should not be used during pregnancy.
Lactation: If the mother is taking the drug, the infant should not be breastfed while taking glimepiride.
When using drugs, make sure to use the correct dose and do not change the dose on your own. Follow a reasonable diet and lifestyle to increase the effectiveness of the drug and control blood sugar.
Drug interactions:
The hypoglycemic effect of the drug may occur when used concomitantly with the following drugs: Phenylbutazone, azapropazone, oxyphenbutazone, insulin, other oral antidiabetic drugs such as metformin, salicylates, para-amino salicylic acid, male sex hormone, chloramphenicol, long-acting sulphonamides, tetracyclines, quinolone antibiotics, clarithromycin, coumarin anticoagulants, fenfluramine, fibrates, ACE inhibitors, fluoxetine, allopurinol, probenecid, anticoagulant sympathomimetic, cyclophosphamide, miconazole, fluconazole, tritoqualine. Reduces the hypoglycemic effect of the drug, which may cause an increase in blood glucose levels when used concomitantly with drugs: Oestrogens, progestagens, saluretics, thiazide diuretics, glucocorticoids, phenothiazine derivatives, chlorpromazine, adrenaline, sympathomimetics , nicotinic acid derivatives, phenytoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide. Drugs with sympathomimetic effects such as beta-blockers, clonidine and reserpine: Signs of hypoglycemia may be reduced or masked. Drinking alcohol can increase or even decrease the blood sugar-lowering effect of the drug. In summary, Canzeal 4mg is an oral hypoglycemic drug that lowers blood sugar by stimulating insulin production. When taking the drug, it is necessary to monitor for abnormal signs to notify the doctor immediately when necessary.
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