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Cadigesic Extra belongs to the group of prescription pain relievers and antipyretics, used when specifically prescribed by a doctor about dosage and frequency. In order to maximize the effects of Cadigesic and prevent the risk of side effects, patients need to take the medicine according to the plan given by the doctor.
1. What is Cadigesic Extra?
Cadigesic extra belongs to the group of ETC drugs (prescription drugs) that help relieve pain and reduce fever. Cadigesic is often used to quickly relieve headache, flu pain, toothache, menstrual pain, ... or improve fever symptoms. Cadigesic is also used in combination with other treatments for the cause of fever or pain.
Cadigesic medicine is prepared in the form of hard capsules, packed in a box of 10 blisters x 10 tablets or a bottle of 200 tablets. This medicine has a shelf life of 36 months from the date of manufacture. This is a product of US Pharma USA Co., Ltd. Each Cadigesic hard capsule contains the following main ingredients:
Main active ingredient: Paracetamol 500mg or 650mg (depending on type). Other excipients: Methyl paraben, tapioca starch, Propylparaben, Magnesium stearate, Talc and Aerosil.
2. Indications for the use of Cadigesic Extra
2.1. Indications Cadigesic for which case? Cadigesic 650mg or Cadigesic 500 is usually indicated for the following cases:
Relief of migraine / headache. Symptomatic treatment of pain caused by menstrual pain, sore throat, sinusitis. Relieve pain after tooth extraction, pain from dental procedures or common toothache. Relieve muscle aches, tendon pain, arthritis pain or injury. Relieves aches and pains caused by colds/flu. 2.2. Pharmacological effects of the active ingredient Paracetamol in the drug Cadigesic *Pharmacodynamics
Paracetamol when combined with caffeine can bring pain relief and antipyretic effects quickly and effectively. According to research, Paracetamol in Cadigesic has a significant effect on the central - peripheral, bringing antipyretic - analgesic effects by blocking the activity of Cyclooxygenase enzyme in the process of synthesizing pain substances. , fever and inflammation of Prostaglandin in the body. In addition, the component Paracetamol also has a strong hypothermic effect thanks to its ability to act on the hypothalamus, increase peripheral blood flow and vasodilatation.
*Pharmacokinetics
Paracetamol in Cadigesic Extra has a rapid and almost complete absorption from the gastrointestinal tract when taken orally. The mean half-life of Paracetamol is between 1.25 and 3 hours. In general, Paracetamol is metabolized mainly in the liver and eliminated via the renal system.
2.1. Indications Cadigesic for which case? Cadigesic 650mg or Cadigesic 500 is usually indicated for the following cases:
Relief of migraine / headache. Symptomatic treatment of pain caused by menstrual pain, sore throat, sinusitis. Relieve pain after tooth extraction, pain from dental procedures or common toothache. Relieve muscle aches, tendon pain, arthritis pain or injury. Relieves aches and pains caused by colds/flu. 2.2. Pharmacological effects of the active ingredient Paracetamol in the drug Cadigesic *Pharmacodynamics
Paracetamol when combined with caffeine can bring pain relief and antipyretic effects quickly and effectively. According to research, Paracetamol in Cadigesic has a significant effect on the central - peripheral, bringing antipyretic - analgesic effects by blocking the activity of Cyclooxygenase enzyme in the process of synthesizing pain substances. , fever and inflammation of Prostaglandin in the body. In addition, the component Paracetamol also has a strong hypothermic effect thanks to its ability to act on the hypothalamus, increase peripheral blood flow and vasodilatation.
*Pharmacokinetics
Paracetamol in Cadigesic Extra has a rapid and almost complete absorption from the gastrointestinal tract when taken orally. The mean half-life of Paracetamol is between 1.25 and 3 hours. In general, Paracetamol is metabolized mainly in the liver and eliminated via the renal system.
3. Dosage and instructions for using Cadigesic extra
3.1. Dosage of drugs Cadigesic extra Cadigesic drugs 650mg and 500mg are used with the following specific doses:
Dosage for adults: Take no more than 6 tablets / day. Dose for children aged 7 - 12: Take 1/2 tablet / time, do not take more than 3 tablets / day. The recommended minimum interval between doses of Cadigesic is 4 hours. In addition, patients should avoid self-medication for pain relief beyond 5 days (for children) and more than 10 days (for adults) or more than 3 days (in case of fever 39.5 degrees C) unless when directed by a doctor.
For people with severe renal impairment with creatinine clearance less than 10mL/min, it is recommended to maintain an interval between doses of at least 8 hours or as directed by a specialist.
3.2. Instructions for proper use of the drug Cadigesic extra Cadigesic drug is in the form of hard capsules, so it should be taken orally. The patient should take Cadigesic with a large glass of water and swallow the tablet whole. Avoid taking the medicine with carbonated drinks, soft drinks or stimulants (such as alcohol/beer).
3.3. Treatment of overdose Cadigesic extra Cadigesic overdose can occur when a patient takes a single dose or repeats a dose of 7.5 - 10g Paracetamol within 1-2 days, or can also due to taking the drug for several days. One of the most dangerous acute toxic effects of Cadigesic overdose is hepatic necrosis, which can lead to death. This phenomenon often has warning symptoms such as nausea, vomiting, abdominal pain, cyanosis of the skin, nails and mucous membranes.
To manage an overdose of Cadigesic extra , the patient needs to receive active supportive treatment. In all situations, the first-line urgent treatment is gastric lavage, preferably within 4 hours of an overdose.
The main antidote for Cadigesic overdose is the use of N-acetylcysteine compounds, which can be administered orally or intravenously. N - acetylcysteine must be taken immediately if it has not been more than 36 hours since the overdose of Paracetamol. Treatment with N - acetylcysteine will promote the best effect when this compound is used less than 10 hours after taking Paracetamol.
When taken orally, N - acetylcysteine needs to be diluted with water to reach a 5% solution and drink immediately after mixing (should be less than 1 hour). The initial dose of N-acetylcysteine should be 140mg/kg clear body, followed by 17 more doses, 70mg/kg each, 4 hours apart.
In addition to the above treatments, the patient may also be given activated charcoal, salt bleach or methionine to treat overdose symptoms.
4. Some side effects of the drug Cadigesic extra
Rash or other allergic reactions may occasionally occur after using Cadigesic Extra. The most common allergy symptoms are urticaria, a red rash, but some people may experience more severe symptoms, accompanied by fever and mucosal lesions.
Patients sensitive to salicylates are rarely sensitive to paracetamol and related drugs in the same class. In rare cases, Cadigesic can lead to side effects such as thrombocytopenia, neutropenia or pancytopenia.
Uncommon side effects: Hematopoietic disorders (leukopenia, neutropenia, pancytopenia), nausea, vomiting, rash, anemia, nephrotoxicity or drug-induced nephropathy long. Rare side effects: Drug hypersensitivity reactions or liver failure (hepatocellular destruction) due to prolonged use of high doses.
5. Some things to keep in mind when using Cadigesic extra
Cadigesic is contraindicated in the following cases:
People who are sensitive or allergic to Paracetamol or any other active ingredient in the drug. People with advanced liver disease. Patients with myocardial infarction or coronary insufficiency. Patients with anemia, lung disease. People with tachycardia or extrasystoles. People with a deficiency of Glucose - 6 - Phosphate dehydrogenase in the body. During the treatment of pain reliever and antipyretic with Cadigesic extra, patients need to be careful about the following things:
People with anemia need to be careful when using Cadigesic extra because cyanosis may occur. People with severe liver/kidney disease should use Cadigesic extra with caution. Concomitant use of alcohol with Cadigesic extra may increase hepatotoxicity. When used in combination with other preparations containing the main ingredient Paracetamol, it can easily lead to poisoning or drug overdose. Patients with signs of severe skin reactions such as Lyell's syndrome, Steven-Johnson syndrome (SJS), acute generalized exanthematous pustulosis (AGEP), or toxic epidermal necrolysis (TEN) syndrome. Care should be taken when using Cadigesic. Long-term use of Paracetamol along with high doses of caffeine can lead to drowsiness, irritability, and headaches if the drug is stopped suddenly. When taking Cadigesic extra with other drugs, there may be interactions and increased side effects of the drug:
Long-term administration of high doses of Paracetamol slightly increases the anticoagulant effect of Coumarin as well as Indandion derivatives. . Concomitant administration of Paracetamol with Phenothiazines may increase the risk of severe hypothermia. Anticonvulsants such as Carbamazepine, Phenytoin, Barbiturates can increase the toxicity of Paracetamol on the liver. Taking Paracetamol with Isoniazid also carries a high risk of increasing hepatotoxicity. Cadigesic is a prescription drug, so make sure you consult your doctor before using it. Hopefully the article has provided you with useful information about the uses, dosage and precautions when using Cadigesic.
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