Uses of butapenem 500

This is an automatically translated article.

1. Uses of Butapenem 500

1.1 What is Butapenem 500? Butapenem 500 is a product of the Central Pharmaceutical Joint Stock Company 2, belonging to the group of drugs for the treatment of parasites, antivirals, antifungals and anti-infectives; Classification of beta-lactam antibiotics, Carbapenem subgroup; with registration number VN- 29168-18, manufactured and registered by TW2 Pharmaceutical Company (Dopharma) - Vietnam.
Butapenem 500 has the main ingredient Doripenem (in the form of Doripenem monohydrate) 500mg content and excipients just enough in the vial for injection. The drug is in the form of a powder for injection.
Butapenem 500 is recommended for use by people 18 years of age and older and adults.
Doripenem has a broad spectrum of activity, against many types of Gram-negative bacteria, Gram-positive aerobic bacteria and some anaerobic bacteria. The spectrum of action of doripenem is similar to that of meropenem and imipenem, however doripenem is somewhat more potent than other carbapenems on Enterobacteriaceae and Pseudomonas aeruginosa.
1.2. Uses of Butapenem 500 Nosocomial pneumonia, including ventilator-associated pneumonia Complicated intra-abdominal infections Complicated urinary tract infections, including pyelonephritis, with or without complications, and Due to its broad-spectrum bactericidal activity against both aerobic and anaerobic gram-positive and gram-negative bacteria, Butapenem 500 can be used to treat mixed or complex infections. complex.

2. How to use Butapenem 500

2.1 How to take Butapenem 500 is given as an intravenous infusion over 1 hour or 4 hours.
Intravenous injection: Add 10 ml of distilled water for injection or 0.9% sodium chloride injection solution to the 250 mg or 500 mg vial of Butapenem, shake gently to make a suspension of 25 mg/ml or 50 mg/ml. This suspension must be further diluted before infusion to the patient.
Dilution before infusion :
The suspension after dilution is further diluted by injecting 50 ml or 100 ml of 0.9% sodium chloride solution or 5% glucose solution into the infusion bag, and shaking to mix. form a transparent solution.
2.2 Dosage Nosocomial pneumonia including ventilator-associated pneumonia/500 mg/every 8 hours/1 or 4/7-14 days Complicated intra-abdominal infections/500mg/every 8 hours/1 /5-14 days Complicated urinary tract infections, including pyelonephritis/500mg/every 8 hours/1/10 days For patients with hospital-acquired pneumonia, infusion in 1 hour. For patients at risk of infection with less susceptible organisms, the infusion should be over 4 hours.
This use time includes the time to switch to oral medication, after at least 3 days of injection, infusion and when the patient has a good progress
2.3 Overdose and missed dose when taking Butapenem 500 * Overdose:
Signs : Symptoms of overdose may cause rash
Treatment : When overdose of doripenem need to stop taking the drug and treat symptomatically until the drug is eliminated by the kidneys. Doripenem can be eliminated by hemodialysis, but no relevant information is available regarding the use of hemodialysis in the event of an overdose of doripenem.
If a hypersensitivity reaction occurs in a patient receiving Butapenem, the drug should be discontinued immediately and appropriate therapeutic measures instituted (eg, corticosteroids, epinephrine, fluids, antihistamine infusions, antihypertensive amines, breathing). oxygen and maintain airway).
If the patient has diarrhea during treatment or after completing treatment with Butapenem 500, it is necessary to monitor, have an appropriate diagnosis and treatment. Some cases of diarrhea and pseudomembranous colitis may resolve with the end of treatment or discontinuation of the drug, however, in some severe cases, fluid and electrolyte supplementation, protein supplementation, and combination therapy may be required. use drugs that are active against C. difficile (oral vancomycin or metronidazole).
* Missed dose:
Take the dose as soon as you remember, if it is almost time for the next dose, skip the missed dose, just take the next dose. Do not take a double dose.

3. Contraindications of Butapenem 500

Patients with allergy or history of allergy to doripenem, other drugs in the carbapenem class, or patients with anaphylaxis to beta-lactam antibiotics.

4. Notes when using Butapenem 500

In addition to the above 5% glucose solution or 0.9% sodium chloride solution, do not mix Butapenem 500 with any other drugs or solutions.
Precautions when using the drug:
Do not use Butapenem 500 by inhalation because it can cause pneumonia. Use with caution in patients with hypersensitivity to other carbapenems, or to cephalosporins, to penicillins due to the increased risk of life-threatening anaphylactic reactions. Patients with a history of hypersensitivity to various allergens are also at increased risk of a life-threatening hypersensitivity reaction to Butapenem 500. Concomitant use of Butapenem 500 with probenecid is not recommended. With caution when co-administered with valproic acid, serum concentrations of valproic acid should be monitored. Dosage should be reduced when used in patients with moderate to severe renal impairment, and the patient is regularly monitored. Use of antibiotics may result in superinfection with non-susceptible fungi and bacteria, including C. difficile diarrhea and pseudomembranous colitis. Therefore, monitoring and appropriate diagnosis should be made if the patient develops diarrhea secondary to treatment with doripenem. Avoid prolonged use of Butapenem 500. Effects of the drug on driving and operating machinery : Caution should be exercised when using for subjects driving and operating machinery.
Use during pregnancy: Doripenem was not teratogenic, had no effect on fetal ossification, and did not affect fetal growth and weight in preclinical trials.
Use during lactation: It is not known whether Doripenem is excreted in human milk. Because many drugs are excreted in human milk, extreme caution should be exercised when Doripenem is administered to nursing mothers
Butapenem 500 reduces valproic acid concentrations below the therapeutic range desired, possibly increasing risk of seizures, caution should be exercised when co-administered. The mechanism of interaction is unknown, however carbapenem may inhibit glucuronide hydrolysis of valproic acid.
Avoid use with some drugs: Probenecid reduces the excretion of Butapenem 500 through the renal tubules, increases the blood concentration of the drug and prolongs the elimination time of the drug. Some other antibiotics such as amikacin, co-trimoxazol, daptomycin, levofloxacin, linezolid, vancomycin.

5. Side effects of Butapenem 500

Very common:
Effects on the central nervous system: Headache. Effects on the digestive system: Nausea, diarrhea. Common:
Bacterial infections: Oral candidiasis, vaginal yeast infections. Skin and Subcutaneous Organisms: Skin rash (including erythema, maculopapular, atopic/bullous dermatitis, urticaria and erythema multiforme). Liver, bile: Increase liver enzyme index. Effects on the lymphatic system and blood: Anemia. Kidney: Decreased kidney function. Local: Phlebitis. Uncommon:
Effects on the digestive system: Colitis caused by C. difficile. Effects on lymphatic system and blood: Thrombocytopenia, neutropenia. Immunological: Hypersensitivity reactions. Frequency not determined:
Stevens-Johnson syndrome, Lyell syndrome, anaphylaxis, convulsions, interstitial pneumonia.
Inform the doctor about the unwanted effects encountered when using the drug.

6. How to store Butapenem 500

Store the powder bottle at room temperature 15 - 30 degrees Celsius. Keep out of reach of children

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.