This is an automatically translated article.
Bondaxil is a prescription medication, used to treat, prevent recurrence and prevent herpes simplex infections of the skin. To ensure the effectiveness of using Bondaxil, patients also need to follow the instructions of a specialist, and refer to the information in the article below.
1. What is the use of Bondaxil?
1.1. What is Bondaxil? Bondaxil belongs to the group of antiparasitic, anti-infective, antiviral and antifungal drugs. The drug has registration number VN-17492-13, manufactured by Hutecs Korea Pharm Co., Ltd - Korea, and imported to Vietnam by Hop Nhat Joint Stock Company.
The drug has the main active ingredient is Acyclovir 200mg, prepared in the form of tablets, blisters of 10 tablets, boxes of 10 blisters.
Bondaxil is recommended for use by adults and children.
1.2. What is Bondaxil used for? Active ingredient Acyclovir has a selective effect on cells infected with Herpes virus. The spectrum of activity of acyclovir is strongest against Herpes simplex virus type 1 (HSV - 1), less effective against Varicella zoster virus (VZV) and Herpes simplex virus type 2 (HSV - 2), weakest effect on Cytomegalovirus (CMV). .
Bondaxil tablets are indicated in the following cases:
Treatment of skin and mucous membranes infected with Herpes simplex, including initial or recurrent genital herpes infections. Prevention of recurrent Herpes simplex in immunocompetent patients. Prevention of Herpes simplex infection in patients with immunodeficiency syndrome. Treatment of chickenpox (also known as varicella). Herpes zoster infection (also known as shingles). The drug is contraindicated in the following cases:
Patients who are allergic to the main active ingredient Acyclovir, Valacyclovir. or any excipients of Bondaxil
2. How to use Bondaxil?
2.1. How to take Bondaxil medicine Bondaxil is taken orally. The patient should take the tablet whole with a large glass of water. Do not crush, break the tablet or chew it before swallowing. Patients can take Bondaxil at any time of the day without regard to food. However, try to take it at the same time each day to avoid forgetting your medication. This will help the concentration of the drug in the patient's blood always keep a stable level, thereby increasing the effectiveness of the drug. Follow the instructions and instructions of the treating doctor. Do not arbitrarily increase or decrease the prescribed dose. 2.2. Dosage of Bondaxil Adult Dose:
Treatment of the onset of herpes simplex, including genital herpes: 200 mg 5 times/day (usually 4 hours apart) for 5 to 10 days. Patients with malabsorption or severe immunodeficiency: 400mg x 5 times/day for about 5 days. Prevention of recurrence of herpes simplex in immunocompetent patients: 800mg divided into 2 to 4 times daily. You can try reducing the dose from 400mg to 600mg/day. Doses higher than 1 gram/day may be used on an individual basis. Treatment should be discontinued every 6 to 12 months for re-evaluation. Prevention of Herpes simplex in immunocompromised patients: 200 to 400 mg/day in 4 divided doses. Preventive treatment of chronic diseases : Not applicable to mild or recurrent Herpes simplex infections. For this case, treatment by stages of relapse will be more effective; 200mg/day in 5 divided doses for 5 days. It is best to use it as soon as symptoms appear. Chickenpox: 800mg/day in 4 or 5 divided doses for about 5 to 7 days. Herpes zoster: 800mg/day in 5 divided doses for 7 to 10 days Pediatric dose:
Treatment and prevention of herpes simplex infection in immunocompromised pediatric patients: Children 2 years of age and older: Dose as adults .
Children under 2 years: Use half the adult dose.
Treatment of pediatric patients with chickenpox: Children 2 years of age and older: 20mg/kg body weight, maximum 800mg/day divided into 4 doses for 5 days. Children > 6 years old: 800mg/day divided into 4 times. Children from 2 to 5 years old: 400mg/day divided into 4 times. Children under 2 years old: 200mg/day divided into 4 times. Dosage of Bondaxil in Renal Impairment: The dose of Bondaxil should be reduced in patients with renal impairment according to creatinine clearance.
CrCl < 10 ml/min:
Herpes simplex infection: 200mg every 12 hours. Varicella-zoster infection: 800mg every 12 hours. CrCl index 10 - 25 ml/min: Varicella-zoster infection: 800mg/day in 3 divided doses every 8 hours.
Handling when missed dose:
In case of missed dose of Bondaxil, it is advisable to supplement as soon as possible. However, if it is almost time for the next dose, skip the missed dose of Bondaxil and use a new dose. Treatment of overdose:
Symptoms: Acyclovir is partially absorbed from the gastrointestinal tract. An overdose of up to 20 grams of acyclovir as a single dose has been reported in patients, also without toxicity. However, when overdose is repeated for many days, there are effects on the gastrointestinal tract (such as nausea and vomiting) and effects on the nervous system (such as headache and dysfunction). Treatment: Patients with an overdose of Bondaxil should be closely monitored for signs of toxicity. Hemodialysis significantly removes acyclovir from the blood and thus may resolve the symptoms of overdose.
3. Notes when using Bondaxil
Do not use Bondaxil after the expiry date on the package. Sensory blisters are open, pills are moldy, change color. Acyclovir is excreted by the kidneys, so dose adjustment is necessary in patients with renal impairment. Elderly patients often have reduced renal function, so dose adjustment is also required for this group of subjects. Both of the above mentioned groups of subjects are at increased risk for neurotoxic side effects and require careful monitoring for adverse events. These side effects were almost all reversible upon discontinuation of treatment. Do not use Bondaxil for pregnant women because of the absolute contraindication. Use with caution in lactating women and if necessary, discontinue nursing. Effects of the drug on the ability to drive and use machines: The phenomenon of drowsiness or dizziness has not been recorded, so it is possible to drive or operate machines.
4. Bondaxil side effects
Renal impairment may be associated with the use of acyclovir in some patients, but this effect is usually reversible and has been reported in response to hydration or following dose reduction or discontinuation. In some patients may progress to acute renal failure. Side effects that often occur after systemic use of Bondaxil include:
Increase in serum bilirubin, increase in liver enzymes, change in hematological tests. Skin rash (including Stevens-Johnson syndrome, polycythemia vera, and toxic epidermal necrolysis), fever, dizziness, headache, and gastrointestinal effects such as nausea, vomiting or diarrhea. Rare: Hypersensitivity and hepatitis and jaundice. If you experience these symptoms, the patient should stop using the drug and notify the doctor for appropriate treatment.
5. Bondaxil drug interactions
Drugs that may interact with Bondaxil include:
Antifungal antibiotics. Aminoglycoside antibiotics such as Gentamicin, Kanamycin, Amikacin, Neomycin, Streptomycin, Paramomycin and Tobramycin. Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen and Naproxen. Cyclosporin drug. Medicines for HIV or AIDS immunodeficiency such as zidovudine. Pentamidine. Probenecid drug. Sulfonamide drugs such as Sulfamethoxazol and Trimethoprim. Tacrolimus drug.
6. How to store Bondaxil?
Bondaxil shelf life is 36 months from the date of manufacture. Store the medicinal product at an ideal temperature below 25 degrees Celsius, do not expose the medicine to direct sunlight. Places with high temperatures, such as next to refrigerators, heaters, or televisions. Avoid storing Bondaxil in humid places such as bathrooms, with humidity higher than 70%. Keep Bondaxil out of the reach of small children. Above is all information about Bondaxil, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Bondaxil is a prescription drug, patients absolutely must not buy and treat at home because they may experience unwanted side effects.
