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Bloxiverz (Neostigmine methylsulfate) is a cholinesterase inhibitor used to reverse the effects of non-depolarizing neuromuscular blocking agents after surgery. The drug was first approved by the FDA on May 31, 2013.
1. What is Bloxiverz?
Bloxiverz 0.5 mg/mL is a prescription medication manufactured by Avadel Legacy Pharmaceuticals, LLC. Bloxiverz contains the active ingredient Neostigmine Methylsulfate and is packaged as an injection at a concentration of 0.5mg/ml.
Neostigmine is a cholinergic muscle stimulant, which is an agent that increases the presence of acetylcholine - a neurotransmitter in the neuromuscular junction. Cholinergic muscle stimulants are cholinesterase inhibitors - blocking the cholinesterase enzyme from breaking down acetylcholine in the synapse, thereby increasing the amount of acetylcholine in the neuromuscular junction for a longer time.
Cholinergic muscle stimulants are generally used to diagnose and treat myasthenia gravis - a chronic disorder that causes muscle weakness. Myasthenia gravis is an autoimmune disease in which autoantibodies bind to cholinergic receptors at the neuromuscular junction and prevent acetylcholine from triggering muscle contractions.
2. What does Bloxiverz do?
Bloxiverz is used to reverse the effect of anesthesia on the function of the musculoskeletal system during surgery.
Bloxiverz should not be treated if the patient is allergic to the main active ingredient or if the patient has:
Bladder obstruction or other urinary problems; A blockage in the digestive tract (intestinal obstruction); Severe disorders of peritonitis (inflammation of the membranes lining the organs inside the abdomen); Coronary artery disease (coronary artery stenosis); Cardiac arrhythmias; Myasthenia gravis. Are pregnant or breastfeeding.
3. How to take Bloxiverz
Bloxiverz is administered intravenously by qualified medical personnel. The patient's breathing rate, blood pressure, oxygen levels, kidney function, and other vital signs will be closely monitored during the infusion. The doctor will also check the patient's reflexes to make sure Bloxiverz is effective in reversing the anesthesia.
Bloxiverz is only used when necessary for surgery, Bloxiverz does not have a daily dosing schedule. Note that Bloxiverz is for intravenous use only and should be injected slowly over a period of at least 1 minute.
Prior to administration of Bloxiverz and until the patient has fully recovered from normal ventilation, the patient should be assured of good ventilation and an airway maintained. Satisfactory recovery will be assessed by adequate return of skeletal muscle tone and respiratory measurements, along with response to peripheral nerve stimuli.
4. Bloxiverz side effects
Although it may be rare, some people can experience very bad and sometimes fatal side effects when taking Bloxiverz. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect of Bloxiverz :
Signs of an allergic reaction reaction : rash, itching, red skin, swelling, blistering or peeling, with/without fever, wheezing... Muscle weakness; Convulsions; Swollen arms or legs. Facial flushing; Creepy; Fast/slow/irregular heartbeat; Shortness of breath ; Dizziness or unconsciousness. Some of the milder side effects of Bloxiverz: Headache; stomachache ; Dry mouth. trouble sleeping....
These are not all possible side effects of Bloxiverz. If the patient or family member has questions about side effects, call the treating doctor for more specific advice.
5. Using Bloxiverz for pregnant and lactating women?
It is not known whether Bloxiverz can harm an unborn baby when administered to a pregnant woman or may affect fertility? However, cholinesterase inhibitors can stimulate the uterus, causing premature labor when used in pregnant women near full term.
Animal studies have shown no evidence of adverse effects when Bloxiverz is used in organogenesis at equivalent doses in humans however no large enough studies have been performed on pregnancy in humans.
Bloxiverz is only used in a very small number of pregnant women and women of childbearing age, the results show that Bloxiverz does not increase the frequency of malformations or have direct or indirect harmful effects on the fetus. with the fetus was observed. The available data show no evidence of increased fetal damage.
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