This is an automatically translated article.
Bestporal belongs to the group of anti-bacterial, anti-parasitic, antifungal and viral drugs, commonly used in the treatment of diseases related to candida, visceral, nail fungus, yeast... Using Bestporal exactly as prescribed by the doctor will help the patient ensure safety and maximize the effectiveness of treatment.
1. What is Bestporal?
Bestporal medicine contains the main ingredient Itraconazole 100mg. This ingredient is known as a synthetic antifungal agent Triazol, which has the ability to promote effectiveness against some fungi, especially Aspergillus spp.
2. Indications and contraindications for taking Bestporal
2.1. Indications for use of Bestporal The drug Bestporal is effective for people with certain types of fungi, indicated for use in the following cases:
Patients with Candida infection in the mouth, throat or vulva, vagina. People with ringworm, toenail and nail fungus (tinea unguium). People with fungal skin infections sensitive to Itraconazole (including fungi caused by Microsporum spp, Trichophyton spp and Epidermophyton floccosum) are common in tinea pedis, inguinal skin, interstitial skin. People with Blastomyces in the lungs and outside the lungs. Bestporal is indicated in the treatment of histoplasmosis, including chronic lung disease and disseminated histoplasmosis. Treatment of intrapulmonary and extrapulmonary Aspergillus in patients who cannot tolerate or are resistant to Amphotericin B. Use in AIDS patients to prevent recurrence of latent fungal infections. Prophylaxis of fungal infections during prolonged neutropenia when other conventional treatments are ineffective. 2.2. Contraindications to use Bestporal Drug Bestporal is contraindicated in the following cases:
Bestporal is not for people who are sensitive to any of the ingredients of the drug. Do not use Bestporal concurrently with certain antiarrhythmic and lipid-lowering Statins. Bestporal is contraindicated in patients treated with oral medications such as Terfenadine, Cisapride, Astemizol, Triazolam and Midazolam. Women who are pregnant or planning to become pregnant should not take Bestporal.
3. How to use and dose of Bestporal
Bestporal drug is prepared in the form of tablets, so patients should use it immediately after eating. Specific reference dosages are as follows:
In case of vulvovaginal candidiasis: Use the drug with a dose of 2 tablets (100mg) x 2 times/day orally for 1 day; or 2 tablets x 1 time / day for 3 days. Treatment of tinea versicolor: Use the drug with a dose of 2 tablets x 1 time / day, used for 7 days. Treatment of ringworm: Use Bestporal with a dose of 2 tablets x 1 time / day for 7 days or a dose of 1 tablet x 1 time / day for 15 days. For cases of high keratinization such as fungal infections on the soles of the feet, the palms need to be used at a dose of 2 tablets x 2 times / day for 7 days or 1 tablet x 1 time / day for a period of 30 days. Patients with candidiasis in the mouth - throat: Use the drug with a dose of 1 tablet x 1 time / day for 15 days. Patients with AIDS, organ transplant or neutropenia: Use the drug at a dose of 2 tablets x 1 time / day for 15 days. Treatment of nail fungus: Need to use Bestporal 2-3 times, each 7 days with a dose of 4 tablets / day, 2 tablets in the morning, 2 tablets in the afternoon. Patients can also take Bestporal for continuous treatment with a dose of 2 tablets x 1 time/day for 3 months. In addition, for visceral fungal infections, Bestporal dosages refer to the following:
Patients with Aspergillus: Use the drug at a dose of 2 tablets x 1 time per day, used for 2-5 months, if the disease spreads Radiation can be used with a dose of 2 tablets x 2 times / day. Patients with Candida infection: Use the drug at a dose of 1-2 tablets x 1 time / day, used for 3 weeks to 7 months. Patients with epidural Cryptococcus: Use Bestporal with a dose of 2 tablets x 1 time / day, used for 2 months to 1 year. Patients with cryptococcal meningitis: Use the drug with a dose of 2 tablets x 2 times/day. Maintenance treatment using Bestporal with a dose of 2 tablets x 1 time / day. Patients with Histoplasma: Use the drug with a dose of 2 tablets x 1-2 times/day, used for 8 months. Patients infected with Sporothrix schenckii: Use the drug at a dose of 1 tablet x 1 time / day, used for 6 months. Patients infected with Paracoccidioides brasiliensis: Use the drug at a dose of 1 tablet x 1 time / day, used for 6 months. Patients infected with Chromomycosis (Cladosporium, Fonsecaea): Use the drug with a dose of 1-2 tablets x 1 time / day, used for 6 months. Patients infected with Blastomyces dermatitidis: Use Bestporal with a dose of 1 tablet x 1 time / day or 2 tablets x 2 times / day, used for 6 months.
4. Bestporal drug side effects
During the use of Bestporal, some side effects may occur including:
Nausea, abdominal pain, headache, feeling of indigestion. In rare cases, allergic reactions such as pruritus, rash, urticaria and angioedema have been reported. Menstrual disturbances, reversible elevations of liver enzymes, and Stevens-Johnson syndrome have been reported in some patients. A rare side effect in Bestporal users is hypokalemia.
5. Drug interactions
Bestporal has the potential to interact with other drugs such as:
Concomitant use with Terfenadine, Astemizol, Cisaprid can increase the concentration of these drugs in the blood plasma leading to life-threatening arrhythmias. Do not use Bestporal with Diazepam, Midazolam, Triazolam oral form. Do not use together with Warfarin drugs because it will increase the anticoagulant effect of Warfarin. Care should be taken when using Bestporal with calcium blockers because it can cause edema, tinnitus, increased risk of inhibiting the metabolism of calcium blockers, leading to an increased risk of congestive heart failure. If using Bestporal with cholesterol-lowering drugs of the HMG - CoA reductase inhibitor group (including drugs such as Lovastatin, Atorvastatin, Simvastatin, Pravastatin...) may increase the concentration of these drugs in the blood, increasing the risk of myositis. or have muscle diseases. Concomitant use with Digoxin will increase the concentration of Digoxin in the blood plasma. Concomitant use with oral antidiabetic drugs will lead to severe hypoglycemia. Using Bestporal with antacids or H2 antagonists (including Cimetidine, Ranitidine) or Omeprazole, Sucralfate, will cause the bioavailability of Bestporal to be significantly reduced, reducing the anti-fungal therapeutic effect. Use of Bestporal with CYP inducers (including Rifampicin, Isoniazid, Phenobarbital, Phenytoin) will result in a decrease in plasma concentrations of the active ingredient Itraconazole.
6. Precautions while using Bestporal
Pregnant women do not use Bestporal unless prescribed by a doctor. Women of childbearing age should use appropriate contraception during treatment with this medicine. In case of suspected neuropathy due to the use of Bestporal, the patient should stop taking the drug. The use of Bestporal in the maintenance treatment of visceral mycosis in patients with AIDS (including Blastomyces, Sporothrix, Histoplasma, Cryptococcus infections) and patients at risk of recurrence should be considered by a specialist. For patients with a history of liver disease or liver toxicity by other drugs, it is necessary to check the liver function when taking Bestporal for a long time because the component Itraconazole in the drug is metabolized mainly in the liver. When Bestporal is used, bioavailability in patients with renal impairment is also often reduced. Therefore, it is necessary to pay close attention to regular observation and adjust the dose accordingly in these patients. Caution should be exercised when using Bestporal in patients with a predisposition to drugs of the Azole class. The basic information about Bestporal in the above article is for reference only. Because this is a prescription drug, patients should not use it on their own, but need to contact a specialist directly to get an appropriate prescription to ensure safety for health.
