Uses of Berlthyrox 100

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Berlthyrox 100 is commonly used to treat conditions associated with thyroid hormone deficiency (hypothyroidism). To better understand the uses, usage and notes when using Berlthyrox, please read the article below.

1. What is Berlthyrox?

Berlthyrox 100 has the main ingredient Levothyroxine sodium, belongs to the group of thyroid hormone drugs, is made in the form of 100mcg tablets, the drug is manufactured by the pharmaceutical company Berlin Chemie AG - Germany.
Berlthyrox 100mcg drug is prescribed by doctors in the following cases:
Treatment of congenital hypothyroidism and acquired hypothyroidism in infants and young children. Management of hypothyroidism in adults. Prevention of recurrent hypertrophy of the thyroid gland after goiter in patients with normal thyroid function. Used to replace thyroid hormone deficiency (also known as hypothyroidism). Treatment of benign thyroid nodules in patients with normal thyroid function. In the treatment of hyperthyroidism combined treatment with antithyroid drugs after achieving normal thyroid status. Treatment and replacement therapy in cases of malignant goiter after thyroidectomy. Treatment and prevention of goiter. Treatment of thyroid hormone deficiency or imbalance. Support in radiation therapy for cancer patients, thyroid suppression test.

2. What are the uses of Berlthyrox 100?

Pharmacodynamics:
Levothyroxine is a hormone mainly formed in the thyroid gland, currently on the market most of the products are synthetic. The main use of hormones secreted by the thyroid gland is to increase the metabolism of tissues in the body, helping to balance the growth and differentiation of cells. Children without or lack of this hormone will slow down the development of the skeletal system and the whole body.
Hormones secreted by the thyroid gland increase oxygen use in tissues and increase the rate of metabolism of body components. Therefore, these hormones have strong effects on organs and nerves. In addition, it also affects tissue, causing the heart to increase contractility.
Levothyroxine is deioted in peripheral tissues to form Triiodothyronine which is thought to be the active tissue form of thyroid hormone. Triiodothyronine is fast acting but has a shorter duration of action than Levothyroxine.
The main effect of Levothyroxine is to speed up cell metabolism.
Pharmacokinetics:
Levothyroxine sodium is incompletely and differentially absorbed from the gastrointestinal tract. It is almost completely bound to plasma proteins and has a circulating half-life of approximately one week in healthy subjects, but longer in patients with myxoid edema.
A large part of Levothyroxine leaves the circulatory system to be taken up by the liver. Part of the Levothyroxine dose is metabolized to Triiodothyronine. Levothyroxine is excreted in the urine as free drug, deionized metabolites and conjugates. Some Levothyroxine is excreted in the feces. The transmission of Levothyroxine across the placenta is limited.
Contraindications of Berlthyrox 100:
Patients with hypersensitivity to the active ingredients or any of the excipients of Berlthyrox 100. The patient has hyperthyroidism but is not being treated for any reason. Patients with recent acute myocardial infarction, acute myocarditis, adrenal insufficiency, or pituitary insufficiency that have not been treated, unless authorized by a physician. If you are pregnant and are taking anti-thyroid drugs. Side effects when using Berlthyrox 100:
If used according to indications and doses, there will be no unwanted side effects during treatment with Berlthyrox hypothyroidism. However, in a few isolated cases, when the dose is not well tolerated by the body or the dose is increased too quickly, causing the body to not adapt in time to the new treatment phase, the typical symptoms of hyperthyroidism can be severe. may occur, such as: heart beat faster than normal, arrhythmia, palpitations, angina, tremor, restlessness, insomnia, increased sweating, feeling hot, fever, vomiting, diarrhea , headache, muscle weakness, cramps, weight loss, menstrual disorders, increased brain pressure. Some patients may have a severe reaction to elevated levels of thyroid hormone. This is called a "thyroid crisis" with any of the following symptoms: Hyperoxia, arrhythmia, tachycardia, hypotension, heart failure, jaundice, confusion, seizures, and coma. In case of hypersensitivity to Levothyroxine or any of the excipients in the composition of the drug, symptoms such as: urticaria, laryngeal edema, bronchospasm leading to difficulty in breathing may occur. Very rarely patients develop anaphylaxis. Children: Heat intolerance, benign intracranial hypertension, neonatal craniocerebral syndrome, transient alopecia areata, and early nodular closure in children. Drug interactions:
Salicylates (pain relievers, antipyretics); dicoumarol (anticoagulant); High dose furosemide (diuretic) (250mg); Clofibrate (a lipid-lowering drug) and other drugs may increase blood levels of Levothyroxine. Rapid intravenous injection of phenytoin may increase blood levels of thyroid hormone and increase the risk of cardiac arrhythmias. Cholestyramine and Colestipol (lipolipids) inhibit the absorption of Levothyroxine, so they should not be taken within 4-5 hours of taking Berlthyrox 100. Absorption of Levothyroxine may be reduced when taken with other drugs. aluminum-containing medicines, stomach antacids, calcium carbonate or iron-containing medicines. Therefore, Berlthyrox should be administered at least 2 hours before these drugs. Propylthiouracil (medicine to treat hyperthyroidism); Glucocorticoids (adrenal cortex hormone); beta-blockers (antihypertensives) and iodinated contrast agents inhibit the conversion of T4 to T3. Sertraline (medicine for depression) and Chloroquine/proguanil (medicine for malaria and rheumatism) decrease the effectiveness of Levothyroxine. Barbiturates (sleeping pills) and some other drugs can increase the breakdown of Levothyroxine in the liver. Levothyroxine requirements may be increased when oestrogen-containing oral contraceptives or hormone replacement therapy are used in postmenopausal women. Sevelamer (a drug that lowers blood phosphate levels in hemodialysis patients) may decrease the absorption and effectiveness of Levothyroxine. Therefore, Berlthyrox 100 should be administered 1 hour before Sevelamer or 3 hours after Sevelamer. Your doctor must check your thyroid hormone levels regularly. Amiodarone (medicine to treat heart rhythm disorders) can cause hyperthyroidism or hypothyroidism due to high iodine levels in the drug. Therefore, special care must be taken when administering to patients with nodular goiter. Levothyroxine may increase the effectiveness of some anticoagulants (coumarin derivatives) and decrease the hypoglycemic effect of antidiabetic agents. Therefore, if these drugs are co-administered with levothyroxine, coagulation parameters and blood glucose levels should be monitored regularly, especially at the start of treatment, and the dose of anticoagulants and anticoagulants should be adjusted. this blood sugar. Soy products may reduce the intestinal absorption of Berlthyrox 100. Dosage adjustment of Berlthyrox 100 may be necessary at the initiation and discontinuation of the soy diet.

3. Note when using Berlthyrox 100

Levothyroxine should be introduced very gradually in patients over 50 years of age and those with longstanding hypothyroidism to avoid any sudden increase in metabolic requirements.
Patients with hypopituitarism or other causes of adrenal insufficiency may respond to treatment with Berlthyrox 100, and corticosteroid therapy should be initiated before Berlthyrox 100 is administered to these patients.
Levothyroxine sodium should be used with caution in patients with cardiovascular disorders, including angina, coronary artery disease, hypertension, and in the elderly.
To minimize the risk of undetected overtreatment side effects, such as atrial fibrillation and fractures associated with low serum thyroid-stimulating hormone (TSH) levels in elderly patients , it is important to monitor serum TSH and adjust dosage accordingly during long-term use.
In individuals with suspected or high-risk cardiovascular disease, it is important to have an electrocardiogram performed prior to initiating therapy with Berlthyrox 100 to detect changes consistent with ischemia, In that case, Levothyroxine should be started at a low dose, then increased cautiously to avoid exacerbation of ischemia or the formation of an infarct.
Thyroid replacement therapy may increase the need for insulin doses or other antidiabetic therapy (such as metformin). Need to care for patients with diabetes, diabetes insipidus.
Subclinical hyperthyroidism may be associated with bone loss. To minimize the risk of osteoporosis, the dose of Berlthyrox 100 should be titrated to the lowest effective level possible.
Parents of children being treated with antithyroid drugs should be advised that partial hair loss may be possible during the first few months of treatment, these effects are usually transient and regrowth is common.
A small number of patients report adverse events when switching between different levothyroxine products. In some cases, symptoms were reported even though thyroid function tests were within the reference range. If patients report side effects when switching between products, consider thyroid function testing. For patients with persistent symptoms after conversion, whether they are biochemically euthyroid or have evidence of abnormal thyroid function, consider consistently prescribing a specific levothyroxine product prescribed well tolerated by the patient. If symptoms or poor control of thyroid function persist despite adherence to a particular product, a prescription for levothyroxine as an oral solution should be considered.

4. How to use the thyroid medicine Berlthyrox 100 effectively

Always stick to the exact dose of Berlthyrox your doctor prescribes. Ask your doctor or pharmacist if you are unsure.
The individual daily dose should be calculated based on clinical and laboratory tests. Initiation of thyroid hormone therapy must be especially cautious in elderly patients, in patients with coronary artery disease, and in patients with severe or persistent hypothyroidism, e.g. Low starting dose
and then gradually increase the dose, regularly checking thyroid hormone levels after each dose increase.
Experience shows that low doses have good effects on low weight people and patients with large goiter.

Children take a maximum starting dose of 1/2 Berlthyrox tablet (equivalent to 50mcg Levothyroxine Sodium) daily, newborns receive 1/2 Berlthyrox tablet (equivalent to 50mcg Levothyroxine Sodium) daily.
In cases of long-term treatment, the dose depends on many factors such as: Age and weight of the child.
Pediatric dosing table:

For infants with congenital hypothyroidism, treatment should be initiated as soon as possible to promote normal psychomotor development. Levothyroxine blood levels should be adjusted to the upper end of the normal range during the first 3 to 4 years. During the first 6 months of life, blood levels of Levothyroxine are more important than TSH (thyroid-stimulating hormone) levels.
In some cases, normalization of TSH levels can take up to 2 years despite adequate levothyroxine intake. If possible, use a dosage form with a low content of the active ingredient at the start of treatment and when increasing the dose for both adults and children.
During long-term treatment, it is recommended to switch to a drug with a high content of active ingredients.

5. Cases needing caution when using the drug Berlthyrox

Here are some cases where patients need to be cautious when using Berlthyrox thyroid medicine:
For people with a history of cardiovascular disease, an electrocardiogram must be measured. Close monitoring of patients with coronary disorders or arrhythmias should be carried out. Be careful when using for people with high blood pressure, adrenal insufficiency, tuberculosis or with anorexia associated with malnutrition. For patients with diabetes, it is necessary to adjust the hypoglycemic agent when using Berlthyrox. For the elderly, it is advisable to check the heart before deciding to take this drug. For pregnant and lactating women, when using the drug, it is necessary to provide an appropriate amount of Levothyroxine, and should be treated continuously. However, during pregnancy, when taking Levothyroxine should not be taken with antithyroid drugs. Because if taken together will have to increase the dose of antithyroid drugs, this is not good for pregnant women. Above is information about Berlthyrox 100's uses, dosage and usage. Patients should carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy drugs to treat at home because there may be unwanted side effects.

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