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Benztropin belongs to the class of anticholinergic drugs indicated in the treatment of parkinsonism, drug-induced extrapyramidal symptoms. Let's learn about the uses, dosage and notes when using Benztropin through the article below.
1. Uses of Benztropine
"What is Benztropine and what is it used to treat?". Accordingly, the drug Benztropine contains the active ingredient Benztropine - belonging to the anticholinergic group. The drug is available in the form of tablets and solution for infusion. Benztropine is indicated in the treatment of the following conditions:
Treatment of all forms of Parkinson's disease, which can be used as monotherapy or in combination with other Parkinson's medications. Treatment of acute extrapyramidal symptoms drug-induced.
2. Dosage of Benztropine
Benztropine belongs to the group of prescription drugs, so the dose of the drug should be prescribed by the treating doctor based on the medical condition. Patients should absolutely not self-medicate without a doctor's prescription. Some dosing recommendations for Benztropine are as follows:
Dosage in adults:
Treatment of drug-induced extrapyramidal symptoms: For severe acute symptoms, the parenteral route is preferred for the first time. treatment, when symptoms are relieved switch to oral administration. The duration of Benztropine therapy depends on the severity of the extrapyramidal reactions, the pharmacokinetics of the drug, and the patient's condition. In case of acute treatment, the recommended dose is 1-2mg/time x 2-3 times/day. The dose is adjusted based on the patient's response, usually the dose will be gradually increased by 0.5mg after 5 days of treatment until the maximum daily maintenance dose is 6mg; Treatment of dystonia: The recommended starting dose is 1-2mg/time/day. The maintenance dose in the next times is 1-2mg/time x 1-2 times/day; Treatment of Parkinson's disease after encephalitis: The starting dose is 2mg/day orally once a day before going to bed or divided into 2-4 times. In highly sensitive patients, a lower starting dose of 0.5 mg orally at bedtime should be considered. The dose can then be increased to 0.5 mg every 5 - 6 days based on the patient's ability to respond, maintaining a dose of 1-2 mg/day; Treatment of Parkinson's: For idiopathic Parkinson's disease, the starting dose of Benztropine is 0.5-1mg/day taken as a single dose at bedtime. Maintenance dose may be increased to 0.5 mg every 5 to 6 days based on patient tolerance (usually 1-2 mg/day). Dosage in children:
Extrapyramidal syndrome: Adolescents and children 3 years of age and older use a dose of 0.02 - 0.05 mg/kg/dose x 1-2 times/day; Early-onset schizophrenic syndrome: Children over 8 years old dose 0.5mg/time every 12 hours. Dosage in patients with hepatic and renal impairment: No dose adjustment is required. Use with caution in children under 3 years of age due to anticholinergic effects.
3. Benztropine side effects
Benztropine can cause some of the following side effects:
Common: Blurred vision, dry mouth, dilated pupils, nervousness, nausea, tachycardia, nervousness, constipation, paralytic ileus; Frequency not determined: Toxic schizophrenia, finger numbness, disorientation, confusion, visual hallucinations, memory impairment, exacerbation of psychotic symptoms, depression, tension vertigo, fever, hyperthermia.
4. Notes when using Benztropine
4.1. Contraindications Contraindicated to use Benztropine in the following cases:
Patients with hypersensitivity to Benztropine or to any component of Benztropine; Children under 3 years old due to the risk of adverse effects such as fatal hyperthermia, severe dehydration. 4.2. Precautions for use Some precautions when using Benztropine are as follows:
Risk of decreased sweating, increased body temperature: The drug can cause hyperthermia and severe anhidrosis. The risk of this condition increases in hot weather conditions, the elderly, alcoholics, people with CNS diseases. Therefore, patients need to use it with caution in hot weather or when exercising. Anticholinergic effects: Benztropine causes anticholinergic effects with symptoms including metabolic disturbances, constipation, urinary retention, blurred vision; Effects on the central nervous system: Patients may experience hallucinations, confusion, and euphoria. Toxic psychotic symptoms or disturbances may occur in patients with psychosis. Therefore, the use of Benztropine in large doses or in patients with hypersensitivity may cause weakness or inability to move certain muscle groups; Use with caution in patients with tachycardia, patients with gastrointestinal obstruction, glaucoma patients, patients with prostatic hyperplasia and/or urinary retention; It is not recommended to use the drug in the treatment of patients with tardive dyskinesia, Benztropine may aggravate the disease symptoms; Note to pregnant women: There have been reports of paralytic ileus in the newborn when the mother used the combination of Benztropine and Chlorpromazine during the second and third trimesters of pregnancy. Therefore, the use of Benztropine is contraindicated in pregnant women; Caution for lactating women: There are no studies demonstrating the excretion in breast milk of Benztropine. However, anticholinergics can inhibit lactation. Therefore, it is recommended that breast-feeding be discontinued during treatment with Benztropine; Note to drivers, operating machines: Benztropine can cause nervous breakdown, mental and physical impairment. Therefore, patients should be warned about performing tasks that require high alertness such as driving or operating machinery.
5. Overdose of Benztropin and how to handle it
Overdosage of Benztropine causes neurasthenia, nervousness, enhancement of psychotic symptoms, listlessness, psychosis in patients being treated with tranquilizers.... In case of occurrence of symptoms. Symptoms of drug overdose, the patient should be taken to a medical facility for timely treatment and treatment.
6. Benztropin drug interactions
6.1. Drug-Drug Interactions Anticholinergics: Concomitant use with Benztropine increases the risk of side effects.
Tricyclics, antidepressants, Haloperidol: Increased risk of death from hyperthermia, increased paralytic ileus or heat intolerance.
Phenothiazines: Concomitant use with Benztropin enhances psychotic symptoms in patients with psychosis, increases the risk of death due to hyperthermia, paralytic ileus or heat intolerance.
6.2. Food-Drug Interactions Alcohol enhances the sedative effect of Benztropine. Drug interactions occur increasing the risk of side effects, reducing the therapeutic effect of the drug. Therefore, in order to ensure safety and effectiveness in treatment, patients need to inform their doctor about all medicines they are using (including non-prescription drugs, prescription drugs, functional foods).
Above is important information about taking Benztropine. Hope to bring you useful information for the treatment process to achieve high efficiency.
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