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Bavencio drug has the main ingredient made from avelumad compound belonging to the monoclonal antibody group. Bavencio is indicated in the treatment of some dangerous diseases such as renal cell carcinoma. However, Bavencio can cause some unwanted side effects. Therefore, before using Bavencio, patients need to carefully study and follow the instructions of the treating doctor.
1. Mechanism of action of the drug Bavencio
What is Bavencio? Bavencio contains avelumad that inhibits tyrosine kinase receptors, including the endovascular growth factor receptors VEGFR-1, VEGFR-2, and VEGFR-3. These receptors are known to be involved in angiogenesis, concurrent tumor growth and cancer progression. The compound in Bavencio binds to PD-L1 to help prevent the interaction between PD-L1 and the PD-1 and B7.1 receptors. This then releases the inhibitory effect of PD-L1 on T lymphocytes. This helps restore immune responses, including an anti-tumor immune response. The association of PD-L1 with PD1 on T and B7.1 lymphocytes will lead to inhibition of T lymphocyte activity and proliferation. Besides, it also inhibits cytokine production.
2. Indications and contraindications to the use of Bavencio
Bavencio is indicated for the treatment of adult patients with metastatic Merkel cell carcinoma. Or the subject needs maintenance treatment for patients with locally advanced/metastatic adenocarcinoma. Or treat patients with advanced renal cell carcinoma.However, Bavencio is also contraindicated in cases of hypersensitivity to the drug's ingredients, or people who regularly drink alcohol, beer, or children under 12 years of age.
3. Dosage and how to use Bavencio
The drug is used by intravenous infusion, when used, it is necessary to have the supervision of the treating doctor.
Dosage of Bavencio will depend on several factors: the condition being treated, the patient's other medical conditions, the patient's response to the drug and current weight. The recommended dose of Bavencio is 10 mg/kg body weight intravenously over a period of 60 minutes every 2 weeks.
The duration of treatment for Bavencio until disease progression or unacceptable toxicity
Before the first 4 infusions of Bavencio, the patient should use antihistamines and paracetamol to prevent associated reactions related to infusion such as skin redness, chills, fever, back pain, abdominal pain, allergies... If no reaction occurs by the fourth infusion, the treating physician may decide to discontinue use. the above drugs before the next infusion is indicated. Or if side effects occur, treatment can be delayed or stopped.
4. Side effects and some notes when using Bavencio
Bavencio drug can cause unwanted side effects in patients when performing treatment. Side effects will vary from case to case. Common side effects include: diarrhea, high blood pressure, fatigue, nausea and vomiting, shortness of breath, decreased appetite, hypothyroidism, cough, headache, joint pain. In addition, some cases may experience side effects such as constipation, infusion-related reactions, weight loss. When experiencing the above symptoms, the patient should immediately contact the doctor for timely support.
Besides, if Bavencio is used in combination with other drugs, some common side effects may occur. These side effects affect more than 1⁄5 users with symptoms such as: diarrhea, high blood pressure, fatigue, nausea, shortness of breath, decreased appetite, hypothyroidism,...
Some notes when using the drug Bavencio
Interaction with the drug Bavencio. The interaction of Bavencio with other drugs has not been determined at this time. However, when using Bavencio, patients should tell their doctor about any drugs they have ever used including prescription drugs, over-the-counter drugs, supplements, herbs... This information will help your doctor. The doctor prescribes the right prescription for each patient. For women who are pregnant or planning to become pregnant, Bavencio may have an adverse effect on the fetus. Therefore, patients should use effective contraception during treatment with Bavencio. For women who are breastfeeding, there is still no clear evidence on the extent to which Bavencio passes through breast milk. Therefore, if a patient in this group intends to use Bavencio, it is necessary to carefully discuss the benefits and risks with their doctor before using it. Hopefully, the above sharing has helped you understand Bavencio medicine as well as how to use it effectively and safely for the health of patients.
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