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Basaglar is a long-acting insulin that helps lower blood sugar levels. The drug is indicated for use in the control of blood sugar in adults and children with diabetes. However, in the process of using the drug can cause some unwanted side effects. Therefore, before using Basaglar, the patient needs to learn carefully the information and must comply with the instructions of the treating doctor.1. Mechanism of action of the drug Basaglar
The compound insulin glargine in Basaglar is similar to insulin in the human body, with a low solubility structure at neutral pH. This compound is completely soluble at the acidic pH of Basaglar injection solution. After injection into the subcutaneous tissue, the acidic solution is polymerized leading to the formation of micro-precipitates, which continuously release small amounts of insulin glargine to help stabilize the concentration of Basaglar over time. Although there is no peak in drug concentrations, the concentration data are predictable. time with the prolonged duration of action of the drug. Insulin glargine is metabolized to two active metabolites M1 and M2. The main action of insulin helps to regulate glucose metabolism. Thus, insulin and similar compounds may lower blood glucose levels by stimulating peripheral glucose uptake, particularly in skeletal muscle and adipose tissue. Insulin also inhibits lipolysis in adipocytes, inhibits proteolysis, and increases protein synthesis.
2. Indications and contraindications to the use of Basaglar
It is indicated for the treatment of lowering blood sugar in adults, adolescents and children 6 years of age and older with diabetes mellitus and requiring insulin therapy.
Basaglar should be used for people with type 1 diabetes. However, Basaglar drug may be contraindicated in cases where the patient is suffering from hypoglycemia, or in a state of ketoacidosis.
3. Dosage and how to use Basaglar
Basaglar is used in the dosage prescribed by the doctor. Furthermore, patients should not use Basaglar in larger amounts or for longer than indicated. Because it can cause harmful effects on the patient's health.
Basaglar is injected under the skin and must not be used with an insulin pump or mixed with other insulins. Additionally, Basaglar should not be injected into a vein or muscle. Because the drug may cause skin damage, bruising, pitting, thickening, scaling, scarring.
4. Side effects and some notes when using Basaglar
Basaglar drug can cause some unwanted side effects during treatment such as lowering blood sugar to low levels and even seriously affecting patients. In addition, there are other side effects such as eye reactions, in some cases insulin treatment can cause the body to produce anti-insulin antibodies, or cause temporary water retention in the body.
Basaglar drug interactions may alter how it works or may increase the effects of side effects. Therefore, before using Basaglar, the patient should inform the doctor of the list of previously used drugs including prescription, non-prescription, herbal medicines so that the appropriate treatment regimen can be selected. At the same time, avoid drug interactions that reduce the effectiveness of Basaglar drugs. Some Basaglar drug interactions:
Basaglar can change blood sugar levels. In this case, it is necessary to adjust the insulin dose to avoid this effect. However, patients need to be cautious when using and stopping using Basaglar. Basaglar drugs can interact with angiotensin-converting enzyme inhibitors, diopyramid, fluoxetin,... Basaglar drugs may interact to increase blood sugar when used together with corticosteroids, danazol, glucagon, estrogen, progestin.. Blood sugar levels may increase or decrease if patients use Basaglar with beta-blockers or other sympathomimetic drugs such as clonidine, guanethidine, reserpin... Some notes when using Basaglar Patients should pay attention to carefully read the instructions before using Basaglar, and strictly follow the instructions of the treating doctor on dosage, how to monitor blood and urine test results, and follow the regimen. eat and exercise. Do not share injection pens with others, even after changing needles. Because infection can occur and spread from person to person. Do not use Basaglar if it is cloudy or discolored or has any unusual signs. The drug is given once a day at the same time so the patient will be instructed to do it at home. However, patients should not arbitrarily use it without understanding how to use it. People with related medical conditions such as liver disease, kidney disease, heart failure or heart problems should inform their doctor before using Basaglar. The above is important information about Basaglar, but it is not a substitute for your doctor's advice. Therefore, before planning to use the drug, the patient should consult the doctor to have the appropriate indications.
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