This is an automatically translated article.
Balversa is indicated in the treatment of carcinomas that have spread to other organs in the body or where surgery cannot be removed. However, Balversa can cause some unwanted side effects during treatment. Therefore, before using Balversa, patients need to learn carefully the information of Balversa and follow the doctor's instructions during treatment.
1. Mechanism of action of the drug Balversa
Balversa belongs to the group of FGFR fibroblast growth receptor kinase inhibitors in oral form, which inhibits the enzyme activity of FGFR1, FGFR2, FGFR3 and FGFR4. Components of the drug Balversa also inhibit the phosphorylation as well as the signaling of FGFR. Thereby reducing the viability of cells with FGFR changes, including mutation, amplification and gene loss. Furthermore, Balversa has been shown to have a tumor suppressor effect on FGFR-expressing cells and on murine tumors including bladder cancer.2. Indications and contraindications to the use of Balversa
Balversa is indicated in the treatment of adult patients with locally advanced or metastatic carcinoma, with altered susceptibility to FGFR3, FGFR2. Or cases progressing to or following at least one prior line of platinum-containing chemotherapy. Included in the 12-month period following adjuvant platinum-based therapy.
However, the drug Balversa may be contraindicated in cases of hypersensitivity to the components of the drug.
3. Dosage and how to use Balversa
Balversa brand-name drug is indicated for the treatment of patients with mutations in the FGFR gene. The recommended starting dose is 8 mg, which corresponds to 2 Balversa 4 mg tablets, taken once daily. Then from day 14 to 21 can increase the dose of the drug to 9mg corresponding to 3 pills of Balversa.
If the patient vomits immediately after taking the medicine, the patient can take the next dose the next day.
Note: The above recommended therapeutic dose for Balversa is for reference only. Therefore, before using Balversa, patients need to be prescribed by a doctor.
If the patient has missed a dose of Balversa, use the missed dose as soon as you remember. However, if the interval between the missed dose and the next dose is too close, skip the missed dose. Patients should not use a double dose of Balversa, because it can cause an overdose.
In case of accidental overdose of Balversa and some signs of unwanted side effects, it is necessary to take the patient to the nearest medical facility for prompt medical assistance. time.
4. Unwanted side effects and some notes when using Balversa
Balversa may cause some unwanted side effects during treatment. These include: dry eyes, swollen eyelids, mouth may become dry and sore, hair loss and breakage is heavy, dry skin, muscle pain, patient feels tired, liver function tests show abnormal results. ....
Balversa may also interact with you to change how it works or may increase the effects of side effects. Therefore, before using Balversa, patients need to inform their doctor about a list of previously used drugs including prescription, non-prescription, herbal medicines so that they can choose the right treatment regimen. and at the same time avoid drug interactions that reduce the effectiveness of the drug.
Some drugs interact with Balversa: alpha blockers, antiarrhythmics, anticancer drugs, azole antifungals, calcium channel blockers, diabetes drugs, H2 receptor blockers, enzyme inhibitors HIV non-nucleoside clones, HIV protease inhibitors...
Some notes when using Balversa
Before using Balversa, patients need to inform their treating doctor about their medical condition or medical history so that the doctor can make an appropriate prescription. People using Balversa may experience vision changes. Therefore, if you notice changes in your vision, including blurred vision, cloudiness, or decreased vision, you should notify your doctor immediately. Balversa may cause higher levels of phosphorus in the blood than is normal. At that time, the patient needs to perform a blood test to check. If a pregnant woman uses Balversa, it can cause serious harm to the fetus and mother. With the information about the drug Balversa, hopefully, it will help patients better understand the mechanism of action of the drug as well as how to use it for the best treatment effect.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
