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Bactirid contains the active ingredient cefixime trihydrate - a cephalosporin antibiotic. Let's learn about the uses and notes when using Bactirid through the article below.
1. Uses of Bactirid
Bactirid medicine 100mg/5ml is prepared in the form of a suspension with two volumes of Bactirid 60ml and 30ml. The main active ingredient of the drug is cefixime trihydrate - a 3rd generation cephalosporin antibiotic indicated in the following cases:
Respiratory tract infections including: otitis media, pharyngitis, tonsillitis, rhinitis, exacerbation of chronic bronchitis, acute bronchitis; Uncomplicated urinary tract infections include: acute cystitis, acute pyelonephritis, gonorrhea, urethritis. Bactirid is contraindicated in patients with hypersensitivity to cefixime, beta-lactam antibiotics or any component of Bactirid.
Pharmacodynamics
Active ingredient cefixime is an antibiotic belonging to the 3rd generation cephalosporin group. Its mechanism of action is inhibition of bacterial cell wall synthesis. Cefixime is less affected by beta - lactamase, so many bacteria resistant to penicillin and some cephalosporins due to the action of beta - lactamase are sensitive and destroyed by cefixime.
The effect of cefixime is effective against common bacteria such as Streptococcus pyogenes, Streptococcus pneumoniae, Salmonella typhi, Escheriachia, Proteus - mirabilis, Haemophilus influenzae, Enterobacter spp., Moraxiella catarrhalis...
Cefixime also has very high activity In vitro, clinical infections caused by anaerobic bacteria such as Lactobacillus, Peptostreptococcus spp., Veillonella spp....
Pharmacokinetics
Absorption process: Cefixime is well absorbed from parenteral and parenteral routes. chemical. After oral administration, about 40-50% of the drug is absorbed through the digestive system, absorption efficiency increases when taking the drug with meals. Cefixime crosses the placenta and the breast milk barrier. Metabolism: Cefixime is metabolised by the liver. Elimination: Cefixime is eliminated primarily by the kidneys.
2. Dosage of Bactirid 60ml and Bactirid 100mg/5ml
Dosage of Bactirid 100mg/5ml depends on the age and infection status of the patient. The dose of the drug should be prescribed by the treating doctor, all information about the dosage below is only a recommendation, the patient absolutely should not use the drug without being prescribed by the treating doctor. The recommended dose of Bactirid is as follows:
Children under 6 months of age: The recommended dose is 0.4ml/kg/day, divided into 1 or 2 oral doses; Children from 6 months to 1 year: The recommended dose is 3.5ml/day; Children from 1 to 4 years old: The recommended dose is 5ml/day; Children from 5 to 10 years old: The recommended dose is 10ml/day; Children from 10 years of age and older: The dose equivalent to an adult is 20ml/day. The recommended dose in patients with renal failure is as follows:
Patients with creatinine clearance greater than 60ml/min: The drug dose is applied as normal; Patients with creatinine clearance from 21 to 60ml/min: Use a dose equal to 75% of the normal human dose; Patients with creatinine clearance less than 20ml/min: Use a dose equal to 50% of the normal human dose. Bactirid is prepared in the form of a suspension, so patients take it orally. For Bactirid 60ml, the patient uses boiled water to cool it into the powder to a volume of 60ml, shake the powder to disperse evenly in the vial, use the oral dose prescribed by the doctor. Note that the drug suspension after reconstitution is only used within 1 week, stored in a dry place, the temperature is below 30oC and protected from sunlight. Shake the suspension well before each use.
In case of forgetting a dose of Bactirid, the patient should take it as soon as he remembers. If the time to forget is close to the next dose, the patient should skip the missed dose and continue taking the medicine as scheduled. Never take a double dose.
3. Bactirid 100mg/5ml side effects
Bactirid medicine 100mg/5ml can cause some side effects as follows:
Digestive disorders such as abdominal pain, diarrhea, vomiting, nausea, flatulence; Uncommon: Dizziness, headache, pruritus, urticaria; Rare: Thrombocytopenia, pseudomembranous colitis, eosinophilia, Lyell's syndrome, changes in liver and kidney function, Stevens-Johnson syndrome. In case of experiencing side effects, the patient should stop using the drug and notify the treating doctor for timely treatment.
4. Note when using
Be careful when using Bactirid in patients with kidney failure, liver failure.
Discontinue use in case of suspected allergic reaction to Cefixime.
Cefixime should be treated with caution in patients with known allergy to other cephalosporins and penicillin-sensitive patients because there is evidence of cross-allergenicity between cephalosporins and penicillins.
Treatment with cefixime in particular and with broad-spectrum antibiotics in general can alter the beneficial flora in the gastrointestinal tract and increase the risk of Clostridium overgrowth. Studies have demonstrated that toxins secreted by Clostridium are a major cause of severe antibiotic-associated diarrhea, including pseudomembranous colitis.
Efficacy and safety of Cefixime have not been established in children under 6 months of age, so its use is not recommended in this population.
Currently, there are no studies proving the safety of Bactirid in pregnant women, women who are breastfeeding should not use the drug in these subjects.
Drivers and machine operators: The drug does not affect the patient's ability to drive or operate machinery.
5. Drug interactions
Bactirid drugs can cause some drug interactions as follows:
Bactirid drugs increase the effect of anticoagulants (warfarin), increase the concentration of Carbamazepine in plasma when used simultaneously; Use of Bactirid can lead to false positive results when performing a urine glucose test using Clinitest, Fehling's solution, Benedict's solution; Use of Bactirid may result in a false-positive result when performing the Coomb test.
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