Uses of bacsulfo

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1. What is Bacsulfo?

Bacsulfo drug is a product manufactured at Branch 3 - Imexpharm Binh Duong Pharmaceutical Joint Stock Company. The drug has the main ingredients: Cefoperazone 1g and Sulbactam 0.5g.
The drug is prepared in the form of a powder for injection. With the active ingredients in the drug, Bacsulfo is effective in the treatment of infectious diseases.

2. Indications of Bacsulfo and contraindications to the use of Bacsulfo

2.1. Indications of the drug Bacsulfo Thanks to the active ingredients in the drug Bacsulfo should be indicated for the treatment of the following diseases:
Bacterial infections, respiratory infections. Peritonitis, bacterial infection in the abdomen. Sepsis . Skin and soft tissue infections. Endometritis, pelvic inflammatory disease, and other bacterial infections of the female genital tract. Urinary tract infections Enterococcus. 2.2.Contraindications of Bacsulfo 1g/0.5g Bacsulfo is contraindicated in patients with hypersensitivity to cephalosporin and beta-lactam antibiotics.

3. Usage and dosage of Bacsulfo

Because Bacsulfo is prepared in the form of a powder for injection, the drug is administered intravenously, intramuscularly and slow intravenous infusion.
Specific dosage for each subject is as follows:
Adults: Most infections will respond to doses from 2 to 4 g/day, so it can be divided into 2 doses 12 hours apart and used for 7 days. day. In case of severe infection, the dose can be adjusted up to 6-16g. When done intravenously, divide the dose into 2-4 times / day and last for 7-14 days. Children: Currently, there are no studies on the effectiveness and safety of Bacsulfo when used in children under 18 years of age. Elderly: In the elderly, the elderly do not need to adjust the dose Renal impairment: Patients with renal failure do not need to adjust the dose, because Cefoperazone can be lightly dialyzed. Accordingly, additional doses are recommended after completion of dialysis. Hepatic Impairment: Impaired liver function causes the serum half-life to be prolonged by 2-4 times. Therefore, dose reduction should be considered in patients with impaired liver function. For patients with liver failure and renal failure, dose reduction is almost mandatory. However, care should be taken not to exceed 1–2 g/day, unless serum concentrations are closely monitored through blood drug measures.

4. Notes when using Bacsulfo

During the use of Bacsulfo, patients should note:
Care should be taken when using cefoperazone and sulbactam for patients who are allergic to penicillin. Pseudomembranous colitis has been reported in patients receiving cefoperazone and other broad-spectrum antibiotics. Disulfiram-like reactions have been reported in patients who consumed alcohol within 72 hours of cefoperazone administration. Patients should be advised not to use alcohol and stimulants when using cefoperazone/sulbactam injection. Pregnancy: Cefoperazone and sulbactam can cross the placenta. In addition, there are currently insufficient well-controlled studies in pregnant women. Because animal studies cannot be used exclusively with humans. Therefore, this drug should only be used in pregnant women when clearly needed. Lactation: Small amounts of cefoperazone and sulbactam may be excreted in breast milk. Although relatively small, care should be taken when using the drug for women who are breastfeeding. Driving and operating machines: Use Bacsulfo with caution when driving or operating machinery.

5. Side effects of Bacsulfo

During use, Bacsulfo drug may occur some side effects as follows:
Digestive disorders, constipation, diarrhea, flatulence, indigestion Fever, itching, rash, urticaria. Nausea and vomiting. In addition to the side effects mentioned above, during use, patients may experience other serious side effects. Therefore, during use, if there are abnormal symptoms, the patient should immediately notify the doctor or pharmacist for advice and early treatment.

6. Bacsulfo interactions

Aminoglycosides: Concomitant use of Aminoglycosides with cefoperazone may increase nephrotoxicity. Concomitant use with anticoagulants increases the risk of bleeding. Concomitant use of bacsulfo with loop diuretics may increase nephrotoxicity. Bacsulfo should not be taken with alcohol for 72 hours or more, because it causes a disulfiram reaction.

7. Treatment of missed dose and drug overdose

7.1. Treatment of missed dose In case of forgetting a dose, the patient should take the medicine as soon as he remembers. However, if it is almost time for the next dose, the patient should skip the missed dose and take the next dose as usual. Never take a double dose to make up for it.
7.2. Treatment of overdose In case the patient overdose occurs due to renal failure, hemodialysis can be used to remove cefoperazone and sulbactam from the body.
Symptoms of drug overdose include increased neuromuscular excitability, convulsions, especially in people with renal failure. Visit a medical facility for medical examination and advice.
In summary, Bacsulfo drug has the main ingredients Cefoperazone 1g and Sulbactam 0.5g. The drug is indicated in the treatment of infectious diseases. To ensure effective treatment and avoid side effects, patients need to take the drug according to the prescription or consult a doctor or pharmacist.
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