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Flurbiprofen is a non-steroidal anti-inflammatory drug with little clinical use. This active ingredient is in the preparation Axofinen 100. So how is Axofinen 100mg indicated and what should be noted when using it?
1. What is Axofinen 100?
What is Axofinen 100? Axofinen medicine has ingredients including Flurbiprofen 100mg and some excipients just enough for 1 tablet. Axofinen 100 is a product researched and manufactured by 2/9 Nadyphar Pharmaceutical Joint Stock Company (Vietnam), circulated in the country with the registration number VD-32203-19.
Axofinen 100mg is prepared in the form of film-coated tablets, packing specifications for each box of 3 blisters x 10 tablets.
Flurbiprofen in Axofinen 100 is a non-steroidal anti-inflammatory drug (NSAID) so it has analgesic and anti-inflammatory effects. Axofinen 100 is non-narcotic and is capable of treating mild pain caused by trauma, menstrual cramps or osteoarthritis pain.
Flurbiprofen's mechanism of action is to inhibit the enzyme Cyclooxygenase, thereby blocking the biosynthesis of prostaglandins (a substance that plays an important role in inflammation).
2. Indications and contraindications of Axofinen 100mg
2.1. Indications Axofinen 100mg is indicated for the treatment of the following cases:
Patients with rheumatoid arthritis, other osteoarthritis and ankylosing spondylitis Certain musculoskeletal disorders and injuries, including inflammation bursitis, periarthritis, shoulder stiffness, tendinitis or peritendonitis, low back pain, sprain; Relieves toothache, menstrual pain, postoperative pain and migraine. 2.2. Contraindications Axofinen 100 is contraindicated in the following cases:
Patients with hypersensitivity to Flurbiprofen and any excipients in the drug; Patients with a history of or ongoing peptic ulcer disease; Patients with a history of allergic reactions, including bronchial asthma, rhinitis or urticaria following the use of Aspirin and other NSAIDs; The patient is pregnant in the last 3 months; Children under 12 years of age should not take Axofinen 100.
3. Dosage, how to use Axofinen 100mg
The recommended dose of Axofinen 100 is as follows:
Adults: 200mg/day, divided into 2 oral doses (corresponding to 1 tablet of Axofinen 100 ). Severe cases or acute exacerbations can be increased to 300 mg/day; Dysmenorrhea: start taking 1 tablet of Axofinen 100, then maintain 50-100mg every 4-6 hours; Osteoarthritis: 200-300mg/day, divided into 2-4 times orally; Dosage of Axofinen 100 for patients with renal failure and the elderly needs to be adjusted accordingly. How to use: Axofinen 100 tablets are prepared for oral use, preferably after meals.
4. Some cautions when using Axofinen 100mg
Patients using Axofinen 100 should be aware of the risk of adverse events as follows:
The most common side effects are stomach ulcers, pain, heat and spasms in the epigastric region, accompanied by sadness. vomiting, regurgitation; In some serious cases, side effects of gastrointestinal bleeding and liver toxicity may occur. Some patients may bleed from peptic ulcers without presenting with abdominal pain. Symptoms of melena, muscle weakness, and dizziness upon change of position suggest gastrointestinal bleeding; Some other side effects of Axofinen 100 include skin rash, kidney failure, ringing in the ears, and delirium. Axofinen 100mg should be used with caution in the following cases:
Axofinen 100 should be especially cautious when prescribed to patients with infectious diseases or a history of peptic ulcer; Absolutely do not prescribe Axofinen 100 to patients with a history of asthma, skin rashes and allergies to Aspirin or other NSAIDs; Patients diagnosed with cardiovascular disease, liver disease or kidney disease should use Axofinen 100 with caution; Do not use Axofinen 100 for pregnant patients (especially the last 3 months) and breastfeeding; Use caution when prescribing Axofinen 100 to drivers and operators of machinery.
5. Drug interactions of Axofinen 100
Caution when using Axofinen 100 in combination with anticoagulants increases the risk of unwanted bleeding that may occur. Flurbiprofen increases the concentration of Lithium in the blood, which can lead to toxicity in the body, so Axofinen 100 should not be combined with Lithium. Axofinen 100 may increase the nephrotoxicity of Cyclosporin when used concomitantly. Although there is not enough clinical and experimental basis to prove that there is an interaction between Acetylcholine chloride (or carbachol) with Axofinen 100. However, in practice, patients with eye surgery are prescribed drops of Flurbiprofen together with Acetylcholine chloride or Carbachol will lose the effect of these two drugs.
Axofinen medicine has ingredients including Flurbiprofen 100mg. Axofinen medicine 100mg is indicated for pain relief, anti-inflammatory in some medical cases. To ensure effective use, patients need to carefully read the instructions of the drug, and strictly follow the instructions of the doctor or pharmacist. Do not arbitrarily change the dose, the way of use to avoid affecting health and causing drug interactions and unwanted side effects.
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