Uses of Avatrombopag

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1. Uses of the drug Avatrombopag

Avatrombopag belongs to the class of thrombopoietin receptor agonists, which increase platelet count but do not activate platelet function. In patients with thrombocytopenia and chronic liver disease, platelet transfusions are often indicated before surgery to reduce the risk of bleeding. Thrombocytopenia is a common complication of chronic liver disease, as a result of the liver disease itself and interferon therapy.
Avatrombopag was approved by the US Food and Drug Administration (FDA) on May 21, 2018 for thrombocytopenia in adults with chronic liver disease. It is the first-line choice for oral therapy in chronic liver disease, reducing the patient's need for blood transfusion prior to surgery. Avatrombopag can increase the platelet count to a minimum of 50,000/mcL.

2. How to use Avatrombopag correctly?

Dosage and frequency of Avatrombopag administration will be determined by the individual patient's platelet count. Avatrombopag comes in tablet form, which is to be taken orally and should be taken with food. Swallow the tablet whole, do not chew or crush for the drug to work well.
When you miss a dose, take it as soon as you remember. If you miss a dose and it is close to the next scheduled dose, skip the missed dose. Do not take 2 doses at once to make up for the missed dose. If you accidentally overdose, monitor your own health. If any of these symptoms appear, contact an emergency center immediately for instructions. Additionally, you will have your platelet levels checked regularly while taking Avatrombopag. Your doctor will review these results and decide if you need to change the dose of your medicine.

3. Avatrombopag . side effects

During treatment with Avatrombopag, you may experience the following undesirable effects:
Fatigue: is a common symptom during treatment with Avatrombopag and is a feeling of exhaustion that often does not go away. when resting. As a result, you may need to adjust your routine to manage fatigue. Plan detailed work and rest times during the day and save energy for more important activities. Gentle exercise can help reduce fatigue, and walking or cycling can help. Headache Thrombotic problems (less common): In rare cases, Avatrombopag can cause a blood clot (blood clot) in a vein or artery leading to stroke, heart attack, embolism. pulmonary embolism or deep vein thrombosis. If you have any signs of a blood clot such as sudden shortness of breath, new or worsening headache, confusion, chest pain, left arm pain, weakness on one side of the body, trouble speaking, loss of consciousness awake, swollen limbs, or pain/redness in limbs, go to the nearest emergency center. Reproductive problems: Exposing your unborn baby to Avatrombopag can cause birth defects, so you should not become pregnant or father a child while you are taking this medicine. During treatment, both women and men need to use safe and effective methods of contraception (condoms, birth control pills, IUDs, ...). Even if you don't menstruate or stop producing sperm, you may still be able to conceive and conceive. You should not breast-feed while you are taking this medicine and for 2 weeks after your last dose.

4. Drug interactions

Blood levels of this drug can be affected by certain foods and drugs, so the combination should be avoided, including: itraconazole, fluconazole, rifampin and verapamil, among others. If you are using enzalutamide, fluconazole, mifepristone, or rifampin, the dose of Avatrombopag may need to be adjusted to address this interaction depending on how your platelet count is. Make a list of all the medications you are taking, including prescription and over-the-counter medicines, herbs, vitamins, and supplements to your doctor for better prescriptions.

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Reference source: oncolink.org