Uses of Autifan 20mg

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1. Uses of Autifan 20mg

Autifan 20mg belongs to the group of drugs to treat dyslipidemia and cardiovascular drugs, with the main ingredient being Fluvastatin 20mg. Fluvastatin works by increasing the number of LDL receptors on the cell surface in the liver, thereby increasing the absorption and catabolism of LDL, while inhibiting the synthesis of VLDL in the liver and reducing VLDL and LDL. In addition, the active ingredient Fluvastatin in Autifan 20 mg also helps to reduce total cholesterol, LDL and triglycerides, and increase HDL in people with high blood fat and mixed dyslipidemia.
Autifan 20mg is made in the form of hard capsules and is used in the following cases:
Primary or mixed dyslipidemia in adults, however, children and adolescents are included in the group. heterozygous family. Autifan 20mg is used as an adjunct in cases where the patient cannot respond to treatment with diet and non-pharmacological therapies (eg exercise, weight loss). Secondary prevention of cardiovascular events affecting the health and life of patients with coronary artery disease after percutaneous coronary intervention. Autifan 20mg drug is effective when used as monotherapy, but recently it is recommended to be used in combination with cholestyramine, fibrates and nicotinamide acid, which still ensures the effectiveness of the drug as well as the safety of use.

2. How to use and dose of Autifan 20mg

Autifan 20mg drug is taken orally, should take the tablet whole with a sufficient amount of water. The drug can be taken on an empty stomach or on a full stomach, should be taken in the evening or before bedtime.
Note, patients need to have a cholesterol-restricted diet and practice this diet before starting as well as maintaining it continuously while taking Autifan 20mg.
Within 4 weeks, the blood fat reduction effect of a single dose of the drug will reach its maximum. Dosage should be adjusted according to the patient's ability to respond to the drug and taken every 4 weeks or possibly longer. Using Autifan 20 for a long time still maintains the effect of the drug.
The starting dose recommended by the doctor is from 40 - 80mg / time / day. Because 20mg dose is only suitable for mild cases. This initial dose should be adjusted according to the individual patient's LDL-C concentration and the therapeutic goal to be achieved.
When using Autifan 20mg in elderly patients or those with renal impairment, no dose adjustment is required. Currently, the use of Autifan 20mg in the treatment of blood fat reduction is still limited. There is no cure for drug overdose. Depending on the symptoms of overdose, the patient will receive appropriate symptomatic treatment along with other functional support measures. In addition, liver function tests should be performed and serum CK levels monitored.

3. Side effects of Autifan 20mg

Autifan 20mg drug can cause some unwanted side effects with the following frequency:
Common: Insomnia, headache, abdominal pain, nausea, dyspepsia, increase in serum creatine phosphokinase and transaminase. Rare: Hypersensitivity reactions with manifestations such as urticaria, rash, myopathy, muscle weakness, myalgia. Very rare: Autifan 20mg very rarely causes thrombocytopenia, anaphylaxis, desensitization, loss of sensation, paresthesia, vasculitis, pancreatitis, hepatitis, facial edema, angioedema, skin reactions with manifestations such as dermatitis, eczema, bullous rash, myositis, lupus, rhabdomyolysis. Frequency unknown: The frequency with which Autifan 20mg causes immune-mediated muscle necrosis has not been determined. Other side effects related to the statin component: Sleep disturbance, insomnia, nightmares, sexual dysfunction, depression, interstitial lung disease, diabetes, hyperglycemia, cognitive impairment with manifestations such as confusion, memory loss, increased HbA1c. For Autifan 20mg in particular and most drugs in general, after taking the drug, if the patient has strange or abnormal symptoms, the patient and family and relatives should immediately contact the doctor. In case of necessity, the patient can be taken to a medical facility for timely and appropriate treatment.

4. Some notes when using Autifan 20mg

Do not use Autifan 20mg in people with hypersensitivity to the ingredients of the drug, people with advanced liver disease, persistently elevated serum transaminase levels without an identifiable cause, pregnant women and nursing mothers. suck. People with risk factors for muscle damage such as the elderly (over 65 years old), people with hypothyroidism, people with kidney disease need to be cautious when using Autifan 20 mg because the statin component is easy to cause effects. secondary is muscle atrophy. In this group of subjects, during treatment, it is necessary to closely monitor for adverse drug reactions. People with liver failure, a history of liver disease or alcoholism should be cautious when using Autifan 20mg because it can lead to death when liver function is impaired. When there are signs of liver failure such as loss of appetite, nausea, vomiting, jaundice, easy bleeding or bruising, impaired brain function, the patient should stop taking the drug. It is best to test liver enzymes before treatment, if AST and ALT are 3 times higher than normal, they should not be used. Hepatitis symptoms will subside after stopping the drug. If you have unexplained muscle pain, muscle weakness, fever, or feel uncomfortable while taking Autifan 20, you should contact your doctor. Before treatment with Autifan 20mg, patients should be checked for CK levels, if the value is 5 times higher than normal, the drug should not be used. Indications for CK test before treatment with Autifan 20mg drug is done in people with renal failure, hypothyroidism, history of hereditary myopathy or statin drug use, history of liver disease or alcoholism, elderly people. 70 years of age) with risk factors for rhabdomyolysis. The benefits and risks need to be weighed in this population. If the CK level test shows 5 times higher than normal levels, then the test should be repeated after 5-7 days. If the results remain the same, do not treat with Autoifan 20mg. In case it can be treated, the patient should immediately notify the doctor when there are symptoms such as muscle pain, weakness, muscle stiffness, cramps, etc. At that time, the patient may be instructed to discontinue the drug depending on the patient's preference. on CK levels and symptoms. People who are taking immunosuppressive drugs such as ciclosporin, erythromycin, fibrate, nicotinic acid, other HMG - CoA reductase inhibitors need to be cautious when taking Autifan 20mg at the same time. Do not use Autifan 20mg with systemic fusidic acid or after stopping fusidic acid treatment for 7 days. If fusidic acid is required, Autifan 20 mg should be discontinued or administered under close supervision. If you have symptoms of muscle pain or weakness, the patient should immediately notify the doctor. Long-term treatment with Autifan 20mg can cause interstitial lung disease. Therefore, if you see symptoms such as dry cough, shortness of breath, fever, fatigue, weight loss, the patient should stop taking the medicine and notify the doctor. Limit driving or operating machinery that requires concentration and high alertness because Autifan 20mg can cause headaches and insomnia. Some undesirable effects such as headache, insomnia may occur, if affected patients should not drive, operate machinery or work at height. Autifan 20 may interact with the following drugs: increased risk of myopathy or rhabdomyolysis when used concurrently with fibrates, high doses of niacin, colchicine, fusidic acid. If combined with ciclosporin, the lowest dose of Autifan 20 mg should be used, including both initial and maintenance doses, because of the potential for increased bioavailability. When Autifan 20mg is used together with warfarin and other coumarin derivatives, caution should be exercised because of the potential for bleeding or an increase in prothrombin time, although the incidence is low. To ensure the lipid-lowering effect of Autifan 20mg, the dose of rifampicin should be adjusted because of the potential for reduced bioavailability. If used concomitantly with glibenclamide, patients should be closely monitored and monitored, especially when the dose of Autifan is 80mg/day. To limit interactions with resins, take the two drugs at least 4 hours apart. Caution should be exercised when Autifan 20mg is co-administered with fluconazole because of the potential for increased drug concentrations. Increased bioavailability of Autifan 20mg when co-administered with H2 antihistamines and proton pump inhibitors. To limit and avoid the effects of drug interactions, before taking Autifan 20, patients need to tell their doctor/pharmacist about their medical history as well as medications (including prescription and non-prescription drugs). ), functional foods, herbs have been used. The use of Autifan 20mg is to reduce blood fat in adults with primary or mixed dyslipidemia. In addition, the drug is also used for the secondary prevention of cardiovascular events in patients with coronary artery disease who have undergone intervention.

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