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Atovast 10mg medicine has the main active ingredient is Atorvastatin 10mg and other excipients in sufficient quantities. Atovast drug 10mg is a cardiovascular drug effective in the treatment of total cholesterol lowering disease, treatment of beta-lipoprotein disorder.
1. What is Atovast 10?
Atovast 10mg medicine has the main active ingredient is Atorvastatin (in the form of Atorvastatin calcium trihydrate) 10mg and other excipients in sufficient quantity. The drug is prepared in the form of film-coated tablets, suitable for direct oral administration. Atovast drug 10mg is a cardiovascular drug effective in the treatment of total cholesterol lowering disease, treatment of blood betalipoprotein disorders.
1.1. Pharmacodynamics of the main active ingredient The main active ingredient Atorvastatin is an HMG-CoA reductase inhibitor.
1.2. Pharmacokinetics of the main active ingredient: Absorption: The main active ingredient, Atorvastatin, is rapidly absorbed from the gastrointestinal tract, absorption of the drug is not affected by food. The bioavailability of the active substance Atorvastatin is low, because of its extensive first-pass metabolism (more than 60%). Peak serum concentrations of the drug occur after about 1 to 2 hours. Distribution: Active substance Atorvastatin is strongly bound to plasma proteins over 98%. Atorvastatin is lipophilic and therefore crosses the blood-brain barrier. Metabolism: Atovast 10mg is converted mainly in the liver (>70%) to active or inactive metabolites. Elimination ability: Atovast 10mg drug is excreted mainly in the feces, less than 2% excreted by the kidneys. 1.3. Main active ingredient Atorvastatin is a cholesterol-lowering drug. The drug is capable of inhibiting cholesterol production in the liver by inhibiting a cholesterol-producing enzyme, HMGCoA reductase. Atovast 10mg reduces the level of total cholesterol as well as LDL cholesterol in the blood (LDL cholesterol is considered the "bad" cholesterol that plays a major role in coronary heart disease). Lowering LDL cholesterol levels slows the progression and even reverses coronary heart disease. Unlike other drugs in this class, the active ingredient Atorvastatin can also lower blood triglyceride levels. High blood triglyceride levels are also associated with coronary heart disease.
2. What disease does Atovast 10 treat?
Atovast 10mg is effective in the treatment of specific conditions as follows:
Active ingredient Atorvastatin is indicated to reduce total cholesterol, LDL-cholesterol, apolipoprotein B and triglycerides and to increase HDL-cholesterol in People with primary hypercholesterolemia Treatment of blood betalipoprotein disorders that do not respond adequately to daily nutrition. Atorvastatin is also indicated for the reduction of total cholesterol and LDL-cholesterol in individuals with homozygous familial hypercholesterolemia.
3. Usage and dosage of Atovast 10mg
Atovast 10mg is not affected by food, so you can take it at any time of the day, regardless of the meal.
Treatment of hypercholesterolemia (heterozygous familial and non-familial) and mixed dyslipidemia: the recommended initial dose is 10-20mg once daily. Those who need a significant reduction in LDL cholesterol (more than 45%) can start with a therapeutic dose of 40mg, taken once a day. The therapeutic dose range of Atovast 10mg is 10-80mg once daily. After starting treatment and/or increasing the dose of Atovast 10mg, it is necessary to assess blood lipids within 2 to 4 weeks and to adjust the therapeutic dose accordingly. Treatment of homozygous familial hypercholesterolemia: dose is 10-80mg/day. Your doctor may prescribe additional use or in combination with other lipid-lowering measures. Combination therapy: Active ingredient Atorvastatin can be used in combination with resin to increase the therapeutic effect. Dosage for patients with renal impairment: no dose adjustment is required.
4. Undesirable effects of Atovast 10mg
Atovast 10mg is generally well tolerated, side effects are usually mild and transient. During use, side effects may occur when using the drug such as: digestive disorders, constipation, flatulence, indigestion, abdominal pain, nausea, vomiting, headache accompanied by dizziness.
5. Drug interactions of Atovast 10mg
Atovast 10mg drug may interact with the following drugs:
Anticoagulants, indandione combined with the active ingredient Atorvastatin will increase bleeding time or blood clotting time. The treating doctor usually prescribes blood clotting time monitoring for people who take the combination of anticoagulants Cyclosporine, erythromycin, gemfibrozil, immunosuppressants, niacin: combined use with Atovast 10mg may cause a risk. increased risk of myopathy. Digoxin: Co-administration with the active ingredient Atorvastatin causes a slight increase in the serum concentration of Digoxin.
6. Some notes when using Atovast 10mg
6.1. Contraindications of Atovast 10mg: People with known hypersensitivity or hypersensitivity to HMG-CoA reductase inhibitors People with progressive liver disease or persistent elevation of serum Transaminase without known cause. Subjects are pregnant and lactating women. 6.2. Precautions of Atovast 10mg Before starting treatment with Atovast 10mg, care should be taken to exclude the causes of secondary dyslipidemia and to measure lipid indices. no less than 4 weeks. During treatment with HMG-CoA reductase inhibitors, if creatine kinase is elevated, myositis develops, or serum liver enzymes are elevated 3 times the upper limit of normal, the dose should be reduced or treatment discontinued. . Use Atovast 10mg with caution in people with liver dysfunction, patients who drink a lot of alcohol. You need to have a reasonable diet before treatment with the drug, and should maintain this diet throughout the treatment with Atovast 10mg. Atovast medicine 10mg has the main active ingredient is Atorvastatin 10mg and other excipients in sufficient quantities. Atovast drug 10mg is a cardiovascular drug effective in the treatment of total cholesterol lowering disease, treatment of beta-lipoprotein disorder. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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