Uses of Aromasin 25mg

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Aromasin drug has the main active ingredient Exemestane - a selective, irreversible steroid aromatase inhibitor. It is used as adjuvant treatment of estrogen-receptor positive postmenopausal women or unknown early breast cancer to reduce the risk of breast cancer recurrence. (spread and localized) and contralateral breast cancer.

1. What is Aromasin? Aromasin effects

Aromasin medicine contains the main active ingredient is Exemestane and other excipients. The drug works as follows:
Exemestane is a member of a new class of drugs used for second-line treatment in postmenopausal women with advanced breast cancer long after treatment with tamoxifen has failed. Exemestane has a particularly favorable mechanism of action compared with other drugs. Exemestane binds irreversibly to the oestrogen-producing enzyme, preventing oestrogen production, until a new enzyme is formed. That, in turn, causes the tumor to starve for estrogen and stop growing. Exemestane is indicated for the first-line treatment of hormone receptor-positive advanced breast cancer in postmenopausal women, either physiologically or under the influence of other causes. Exemestane is indicated for the second-line treatment of advanced breast cancer in physiologically postmenopausal women or postmenopausal women after monotherapy with anti-estrogen therapy. . Exemestane is also indicated as a third-line treatment in the treatment of advanced breast cancer in women following combination hormone therapy.

2. Indications for treatment with Aromasin

Aromasin medicine 25mg is indicated in the treatment of diseases such as:
Late stage breast cancer in postmenopausal women (natural or artificial) after failed treatment with anti-estrogen drugs. As an adjunct to the treatment of early-stage, estrogen-receptor-positive breast cancer in postmenopausal women after 2 to 3 years of initial therapy with tamoxifen.

3. Undesirable effects of Aromasin

The undesirable side effects that occur are usually relatively mild and moderate. Common adverse reactions that may be associated with Aromasin are fever, nausea, fatigue, increased sweating and dizziness. Other less common adverse reactions include headache, insomnia, pain, skin rash, abdominal pain, anorexia, depression, vomiting, hair loss, peripheral and leg edema, constipation or abdominal distension, dyspepsia, and dyspepsia. . A rare side effect is a decrease in lymphocytes in people taking Aromasin, especially in people with pre-existing lymphocytopenia. However, the mean lymphocyte counts in these cases did not change significantly over time and no corresponding increase in viral infection was noted. Other side effects include leukopenia and thrombocytopenia.

4. Dosage and how to use Aromasin

4.1. How to use Aromasin: Aromasin 25mg is a tablet that is taken orally. Drink after eating.
4.2. Dosage of Aromasin: For adults and the elderly:
The recommended dose is 1 tablet of Aromasin 25mg/time/day. The doctor will prescribe continued treatment with Aromasin 25mg until the tumor has not progressed anymore. No dose adjustment is necessary for patients with impaired liver or kidney function. For children:
Aromasin is not recommended for use in children. People with early breast cancer must take the drug for as long as 5 years under sequential adjuvant therapy (tamoxifen followed by Exemestan). If the tumor recurs, discontinue use of Exemestane.
People with advanced breast cancer must take Exemestane until there are signs of good progress.
At the same time, when using it, it is necessary to supplement vitamin D and calcium.
4.3. Aromasin Overdose Currently, there is no specific antidote for Aromasin overdose. If overdosage is suspected, vital signs should be closely monitored, symptomatic treatment, supportive treatment (eg, fluid rehydration, electrolyte supplementation in case of severe vomiting or severe diarrhea).

5. Aromasin drug interactions

Drugs that stimulate the CYP3A4 isoenzyme (eg, rifampicin, phenytoin, deferasirox) decrease Exemestane concentrations. The dose of Aromasin should be increased to 50 mg/day in patients receiving these drugs concomitantly. Hypericum perforatum (St. John's grass) reduces the concentration of the active ingredient Exemestane. Do not use the drugs Cimicifuga racemosa (thang ma), Angelica sinensis (dong quai) for people with estrogen-dependent breast cancer. Do not use in combination with estrogen-containing drugs because these drugs reduce the effect of Exemestane. Exemestane reduces the concentration and effect of the active ingredient Maraviroc (a drug that prevents HIV from entering CD4 T cells by blocking the CCR5 receptor).

6. Note when using Aromasin

Aromasin 25mg should not be used in premenopausal women because the effectiveness and safety of the drug has not been evaluated in this population. Therefore, in clinical practice, doctors often order some laboratory tests to make sure you are in a postmenopausal state by performing tests to evaluate the levels of LH, FSH and estradiol. Aromasin should not be used in combination with estrogen-containing drugs because it is possible to reverse the pharmacological effects of Aromasin. For pregnant or lactating women: In animal reproduction studies, Aromasin 25mg has caused some toxicity. Therefore, Aromasin is contraindicated in pregnant and lactating women. If you accidentally take the drug, stop using it immediately.

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