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What is Arduan? Arduan is used effectively to relax muscles in anesthesia in many different types of surgery. The drug is prepared in the form of lyophilized powder for injection. Refer to the article below to get more useful information about Arduan.1. Uses of the drug Arduan
Arduan medicine has the main active ingredient is Pipecuronium Bromide 4mg and other excipients. In particular, Pipecuronium Bromide has a non-barbiturate structure, has an oil body structure that is worse than that of water, so the anesthetic time is quite slow (about an hour after injection). The drug temporarily inhibits the central nervous system, so during surgery, the patient will lose pain sensation.Drugs that inhibit the autonomic nervous system including the sympathetic and parasympathetic systems but do not affect the heart and do not stimulate the body to secrete anti-inflammatory substances such as Histamine, Cytokine,...
Arduan is prescribed to anesthetize the patient before going to the operating table so that the catheter can be easily inserted into the trachea. At the same time, this drug also helps relax muscles for 20-30 minutes longer, no longer feeling pain during surgery.
On the other hand, Arduan is contraindicated in patients with myasthenia gravis, hypersensitivity to any ingredient of the drug. In addition, the drug is also not prescribed for people with mobility impairments, lung diseases such as respiratory failure,...
2. Dosage and usage of the drug Arduan
The anesthetic Arduan is administered intravenously. The drug will be most effective when it is infused right after the preparation is complete. The recommended dosage of the drug is as follows:Before surgery, it is necessary to inject 0.06-0.08 mg/kg body weight (ie, about 1 vial of 4 mg for a person weighing 50 kg) with catheterized patients. endotracheal. In succinyl catheters, the initial anesthetic dose is approximately 1⁄2 doses compared with intubated patients. The maintenance dose for muscle relaxation and anesthesia is 1⁄4 of the initial dose. For people with kidney damage, do not use doses exceeding 0.04 mg/kg body weight. If a repeat injection is required, use 1/4-1/3 of the starting dose. Higher doses may prolong the effect of the drug. To use the drug safely, patients need to strictly follow the doctor's regulations on dosage and use. The drug does not usually cause an overdose or missed dose because Arduan is used under the guidance of medical professionals.
3. Side effects of the drug Arduan
It has been recorded that patients using Arduan encountered unwanted side effects such as anaphylaxis, cardiac arrhythmia,... Some rare side effects such as severe hypotension. This symptom will quickly disappear and do not cause serious health effects.In addition, some side effects that are less common to patients such as: rash, scattered blood clots, oliguria, shortness of breath...
The above are not all side effects of Arduan. If during the course of taking the drug, you experience any unusual side effects, you should notify your doctor for advice and timely treatment.
4. Arduan drug interactions
Drug interactions may decrease the effectiveness of Arduan, or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including over-the-counter medicines, vitamins, prescription drugs, and herbal products. Do not start, stop or change the dose of any medicine without your doctor's consent. Here are some drugs/drugs that may interact with Arduan.Prior blockade, caused by depolarization of succinylcholine, may potently enhance the effect of pipecuronium bromure. Inhalation anesthetics (halothane, methoxyflurane, diethylether) and thiobarbiturates may potentiate or prolong the effects of pipecuronium bromure. Among the antibiotics that have been studied at routine surgical doses (gentamicin, clindamycin, ampicillin and tetracycline) have not been found to affect the effect of Arduan, as tested by spasticity test. Since this test is not available, the possibility of an interaction cannot be ruled out - as with other non-depolarizing muscle relaxants - which in some cases may prolong the postoperative period. So when using Arduan and antibiotics at the same time, you should be careful and carefully monitor the patient.
5. Use Arduan safely
For people with kidney, liver or movement disorders, attention should be paid to monitoring. There is not enough evidence to conclude how the drug affects the development of the fetus, so it should only be used in an emergency when the benefits outweigh the risks. Breastfeeding women can use this medicine if prescribed by a doctor. Store Arduan medicine in a dry, well-ventilated place, avoiding excessive humidity and sunlight. The above article has helped readers answer questions about the use of Arduan as well as important notes. Hopefully with the above information, readers will use the drug safely and avoid unwanted side effects.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
