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Anikef Sterile is a semi-synthetic antibiotic, with a broad antibacterial spectrum, commonly indicated for the treatment of respiratory and urinary tract infections,...
1. What is Anikef Sterile750mg?
Anikef Sterile drug with the main ingredient is Cefuroxime sodium - a 2nd generation Cephalosporin antibiotic.
Anikef Sterile is antibacterial through inhibition of bacterial cell wall synthesis by binding to essential proteins on the wall. cells, thereby preventing the multiplication of bacteria. The drug has a broad spectrum of activity against many common pathogenic Gram-negative and Gram-positive bacteria, including strains of beta-lactamases. In particular, the Cefuroxim component of Anikef Sterile is very stable to many beta-lactamase enzymes of gram-negative bacteria.
After entering the body, Anikef Sterile is rapidly absorbed into the plasma, enters the circulatory system and is eliminated in the urine.
2. Indications of the drug Anikef Sterile
Anikef Sterile is indicated for the treatment of the following infections
Respiratory tract infections. Gastrointestinal and abdominal infections. Urinary tract and genital infections. Sepsis . Skin and soft tissue infections. Meningitis. Prophylaxis of post-operative infections.
3. Contraindications of the drug Anikef Sterile
Anikef Sterile should not be used in patients who are allergic to Cefuroxime or cephalosporin antibiotics and any other ingredient of the drug.
Precautions when using Anikef Sterile:
Caution should be exercised when using Anikef Sterile in patients allergic to Penicillin due to the possibility of cross-reactivity. Long-term use of Anikef Sterile can lead to the proliferation of non-susceptible, resistant bacteria in susceptible strains. Monitor for symptoms of pseudomembranous colitis while taking Anikef Sterile. There are no studies demonstrating the toxicity of Anikef Sterile in embryos and children. However, the benefits still need to be weighed before using Anikef Sterile for pregnant women, especially the first 3 months of pregnancy and women who are breast-feeding.
4. Dosage and usage
How to use:
Anikef Sterile is prepared as a powder for injection. Mix the drug with a suitable solvent for intramuscular or intravenous injection. Dosage:
Common bacterial infections in adults: 750mg (1 vial) x 2-3 times/day. Intramuscular or intravenous injection; Severe infections in adults: From 750mg - 1.5g (1-2 vials) x 2-3 times/day. Intravenous injection. Maximum dose 3-6g/day x 10 days. Patients with renal failure glomerular filtration rate 10-20mL/min: 750mg (1 vial) x 2 times/day. Intravenous injection. Patients with renal failure glomerular filtration rate <10mL/min: 750mg (1 vial)/day. Intramuscular or intravenous injection. Common bacterial infections in children > 3 months: Dose 50-100mg/kg/day, divided into 2-3 times. Intravenous injection. Severe infections in children: 100mg/kg/day, divided into 2-3 times. Intravenous injection. Bone and joint infections in children: 150mg/kg/day, divided into 2-3 times. Intravenous injection. Meningitis in children: 200-240 mg/kg/day, divided into 2-3 times. Intravenous injection.
5. Anikef Sterile drug interactions
Anikef Sterile can interact with some drugs when taken together as follows:
Sodium bicarbonate and ranitidine reduce the effect of Anikef Sterile, should be taken at least 2 hours apart. High doses of probenecid resulted in decreased elimination of Anikef Sterile, higher plasma concentrations and a longer duration of action. Combination of Anikef Sterile and aminoglycoside drugs, potent diuretics increases the risk of nephrotoxicity. Using alcohol, tobacco, and alcoholic foods while taking medication can change the effect of the drug.
6. Anikef Sterile side effects
Some unwanted effects may occur when taking Anikef Sterile medicine
Abdominal pain, nausea, vomiting, enteritis, loss of appetite and weight gain. Sudden high fever and chills. Allergic reactions, itchy rash and swollen glands. Heart palpitations, shortness of breath, and chest pain. Jaundice, pale skin and bruising. Anemia and bleeding. Symptoms of epilepsy. Liver and kidney dysfunction. Vaginal itching. Thus, Anikef Sterile is a Cephalosporin antibiotic with a broad antibacterial spectrum, indicated on many infections caused by susceptible bacteria. To avoid superinfection and drug resistance, it is necessary to use the correct dose and time prescribed by the doctor.
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