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Anastrozole Stada 1mg drug has the main active ingredient Anastrozole 1g and other excipients in sufficient quantities. Anastrozole Stada 1mg is a medicine that treats cancer and affects the immune system.
1. What is Anastrozole Stada 1mg?
Anastrozole Stada 1mg drug has the main active ingredient Anastrozole 1g and other excipients in sufficient quantities. Anastrozole Stada 1mg is a medicine that treats cancer and affects the immune system. The drug is prepared in the form of film-coated tablets, suitable for direct oral use.
1.1. Pharmacodynamics of the active ingredient Anastrozole is a non-steroidal aromatase inhibitor, highly selective and potent for postmenopausal women, oestradiol is produced mainly from the conversion of Androstenedione to Oestrone by the aromatase enzyme complex in peripheral tissues, then Oestrone is converted to oestradiol. A decrease in the amount of Oestradiol in the blood has been shown to have beneficial effects in people with breast cancer.
1.2. Pharmacokinetics of the active substance Absorption: Anastrozole is rapidly absorbed and reaches maximum plasma concentrations within 2 hours after oral administration. Elimination: Anastrozole is eliminated slowly with a half-life of 40-50 hours. Food may slightly decrease the rate of absorption but does not have a clinically significant effect on steady-state plasma concentrations when administered as a single daily dose. Anastrozole pharmacokinetics are also independent of the age of postmenopausal women. Metabolism: In postmenopausal women, Anastrozole is extensively metabolised, anastrozole is metabolised by N-dealkylation, hydroxylation and glucuronication.
2. What disease does Anastrozole Stada 1mg treat?
Anastrozole Stada 1mg is indicated for the adjuvant treatment of postmenopausal women with estrogen receptor-positive early breast cancer. Anastrozole Stada 1mg is also indicated in the treatment of advanced breast cancer in postmenopausal women.3. Usage and dosage of Anastrozole Stada 1mg
3.1. How to use Anastrozole Stada 1mg drug is prepared in the form of film-coated tablets, suitable for direct oral use.
3.2. Dosage The therapeutic dose for adults, including the elderly, is 1 tablet per day.
For children: Do not use the drug for children Liver failure: No dose adjustment is required for people with mild hepatic impairment Renal impairment: No dose adjustment is required for people with mild renal impairment and fit
4. Undesirable effects of the drug Anastrozole Stada 1mg
A very common vascular adverse effect is the occurrence of hot flashes, usually of mild or moderate severity.
Common adverse effects, including
Systemic: Mild or moderate body weakness. For the musculoskeletal system, connective tissue and bones: Pain or stiffness in the joints is usually mild or moderate. For the reproductive system and mammary glands: Vaginal dryness, usually mild or and moderate. For skin and subcutaneous tissue: Hair thinning, usually mild or moderate. Rash, usually mild or moderate. For the digestive system: Nausea is usually mild or and moderate. Diarrhea is mild and moderate. Nervous system: Headache, usually mild or moderate. For the hepatobiliary system: Increases alkaline phosphatase, alanine aminotranferase and aspartate aminotransferase. Uncommon (0.1-1.0%) Reproductive system and mammary gland: Vaginal bleeding is usually mild or moderate. Metabolism and nutrition: The occurrence of anorexia is usually mild or moderate. Increase in blood cholesterol, usually mild or moderate. For the digestive system: Vomiting is usually mild or and moderate. Very rare side effects of the drug are the appearance of erythema multiforme, allergic reactions including angioedema, urticaria, anaphylaxis, Steven-Johnson syndrome.
5. Interactions of Anastrozole Stada 1mg
Clinical drug interaction studies of Anastrozole Stada 1mg with Antipyrin and Cimetidine showed that co-administration of Anastrozole Stada 1mg with other drugs did not result in clinically significant cytocrome P450 receptor-mediated drug interactions. Concomitant use of estrogenic therapies with Anastrozole Stada 1mg is not recommended. The reason is that it can negate the pharmacological effect of the active ingredient Anastrozole. Tamoxifen should not be used concurrently with Anastrozole Stada 1mg because it may reduce the pharmacological effect of Anastrozole active ingredient.
6. Some notes when using Anastrozole Stada 1mg
6.1. Contraindications of the drug Women are in the perimenopausal stage. Pregnant women and those who are breastfeeding. Patients with severe renal impairment with creatinine clearance less than 20ml/min. People with moderate to severe liver disease. People with sensitive or hypersensitivity to the main drug Anastrozole or to any of the excipients of the drug. Estrogen-containing therapies should not be used in conjunction with Anastrozole as they may negate the pharmacological effect of the drug. Anastrozole Stada 1mg should not be used at the same time as tamoxifen. 6.2. Drug precautions Anastrozole Stada 1mg should not be used in children because safety and efficacy have not been established in this population. A woman's menopausal status should be determined by biochemical testing in those with suspected endocrine status. There are no data on the safety of the use of Anastrozole Stada 1mg in patients with moderate to severe hepatic impairment, or in patients with severe renal impairment with creatinine clearance less than 20ml/min. Women with existing osteoporosis or at risk of osteoporosis should have a formal evaluation of bone density with a bone density meter such as a Dexa scanner before treatment with Anastrozole Stada 1mg and periodically thereafter. Because Anastrozole Stada 1mg reduces circulating estrogen levels, leading to a decrease in bone mineral density. The data correspond to the effect of Bisphosphonate on Anastrozole-induced bone mineral density loss. Use of drugs for pregnant and lactating women: Anastrozole Stada 1mg is not used for pregnant and lactating women. Anastrozole Stada 1mg drug has the main active ingredient Anastrozole 1g and other excipients in sufficient quantities. Anastrozole Stada 1mg is a medicine that treats cancer and affects the immune system. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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