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Amrfen is an antipyretic and pain reliever with the main ingredient being Dexibuprofen 200mg. The drug works in the treatment of musculoskeletal diseases: rheumatoid arthritis, osteoarthritis,... So how does Amrfen work, dosage and indications? We invite you to read the article below.
1. Uses of Amrfen
Amrfen is indicated to relieve symptoms of bone and joint diseases: rheumatoid arthritis, rheumatism, osteoarthritis.
In addition, Amrfen is also effective in the treatment of mild pain, moderate pain in the following cases: back pain, pain after surgery, spondylitis, headache, toothache, muscle pain, neuralgia, due to the common cold, acute gout, arthritis, sprains, bruises, pain secondary to tendinitis, tenosynovitis, synovitis. The active ingredient Dexibuprofen is the S(+) isomer of ibuprofen, which blocks prostanoid synthesis in inflammatory cells through COX-2 inhibition of COX arachidonic acid.
Amrfen has anti-inflammatory effects stemming from the reduction of prostaglandin E2 and prostacyclin leading to reduced vasodilation and edema increasing blood permeability and the activity of inflammatory mediators, when prostaglandin reduction in the hypothalamus causes antipyretic effect of the drug.
Amrfen's analgesic effect stems from decreased levels of prostaglandins that sensitize nociceptors to inflammatory mediators at pain sites and enhance transmission from pain-causing fibers in the spinal cord.
2. Dosage - How to take Amrfen
Amrfen dosage is for reference only. In order to have the right dosage for each medical condition and severity of the disease, doctors and medical staff give specific dosages for each different patient.
Dosage in adults: Pain relief: 600-900mg/day divided into 2 -3 times, up to a maximum of 400mg once a day. If pain is acute, severe pain, the dose can be increased to 1200mg/day. Dosage in children: Amrfen is not recommended for use in children under 18 years of age because the safety of this age group is not well documented. Dosage in the elderly: The lowest dose of Amrfen that responds well to the patient should be used. Dosage for patients with hepatic impairment, mild and moderate renal impairment should be closely monitored. If you forget to take a dose of Amrfen, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and never take a double dose.
3. Drug interactions
Drugs that can interact with Amrfen:
Methotrexate; ACE inhibitors; Anticoagulants such as aspirin, warfarin; diuretics such as furosemide; Lithium.
4. Contraindications to taking Amrfen
Patients with advanced peptic ulcer disease. Severe hematological disorders. Severe liver and kidney dysfunction: severe liver failure, severe renal failure. Severe hypertension. Severe heart failure. Patients with hypersensitivity to the ingredients in Amrfen Asthma Bronchospasm when taking aspirin Other NSAIDs
5.Side effects when taking Amrfen
Digestive disorders Anaphylaxis Hematologic disorders Stevens-Johnson syndrome Lyell syndrome Liver, kidney, central nervous system, circulatory, sensory, cardiovascular system dysfunction. It is possible that patients using Amrfen will appear other undesirable effects that are not specified above. The patient's family or patient should immediately notify the doctor or pharmacist of their unusual condition while taking the drug to be promptly dealt with other serious adverse effects
In short, Amrfen is a Antipyretic, analgesic, anti-inflammatory effects prescribed by doctors. To make sure that you are using Amrfen safely, for the correct indication, and at the right dose, you need to consult with your doctor. If you still have any questions about the use of the drug or the side effects of the drug, please contact your doctor/pharmacist immediately for advice.
