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Amoxicillin is a widely used penicillin antibiotic. This antibiotic is present in many different commercial products, including Amoxicillin 250 of Mekophar Pharmaceutical Chemical Joint Stock Company. What are the effects of Amoxicillin 250?
1. What is Amoxicillin 250?
What is Amoxicillin 250? Amoxicillin 250 is a product of Mekophar Pharmaceutical Chemical Joint Stock Company (Vietnam), prepared in the form of an oral powder with each 2.5g pack.
Ingredients in each package of Amoxicillin 250 include:
Main active ingredient: Amoxicillin trihydrate equivalent to antibiotic Amoxicillin 250mg; Some excipients are just enough in one package such as Gelatin, strawberry flavor powder, RE sugar... Amoxicillin belongs to the beta-lactam family, class A penicillin group with broad antibacterial spectrum on many strains of Gram-negative bacteria and Gram-positive bacteria. positive . The action of Amoxicillin 250 is very effective on growing and mitotic strains of bacteria through the mechanism of blocking the biosynthesis of the bacterial cell wall.
The extent of absorption of the antibiotic Amoxicillin is not affected by food, occurs rapidly and completely from the gastrointestinal tract when compared with an antibiotic of the same class, Ampicillin. Peak plasma concentrations of Amoxicillin reach about 5 mg/ml after oral administration of 1 sachet of Amoxicillin 250 about 1-2 hours. Notably, Amoxicillin crosses the placenta and is excreted in human milk in small amounts.
The half-life of Amoxicillin is about 1-1.5 hours, which may be prolonged in neonates, elderly patients or with impaired renal function. Approximately 60% of an oral dose of Amoxicillin 250 is excreted unchanged in the urine within 6 hours.
2. Indications of Amoxicillin 250
The effect of Amoxicillin 250 is applied in the treatment of infectious diseases caused by strains still sensitive to Amoxicillin, including:
Respiratory tract infections; Biliary tract infection; Digestive infections; Genitourinary infections; Skin or joint infections.
3. Contraindications of Amoxicillin 250
Contraindications of Amoxicillin 250 in the following cases:
Patients with predisposition or history of hypersensitivity to Amoxicillin, other Penicillins or Cephalosporins; The patient was diagnosed with infectious mononucleosis.
4. Dosage of Amoxicillin 250
Dosage of Amoxicillin 250 can refer to the following:
The recommended adult dose is 2-4 packs of Amoxicillin 250 each time, taking 2-3 times a day.
For children, it is recommended to use Amoxicillin at a dose of 25-50mg/kg/day, divided into 2-3 oral doses, depending on age as follows:
Children over 12 years old: The dose is the same as adults; Children 5-12 years old: Take 1-2 packets of Amoxicillin 250 each time, 2 times a day; Children 1-5 years old: Take 1 pack of Amoxicillin 250 each time, 2 times a day; Children under 1 year old: Take 1⁄4 to 1⁄2 packets of Amoxicillin 250 each time, 2 times a day. It should be noted: The above dosage of Amoxicillin 250 is for reference only, patients need to strictly follow the instructions, Amoxicillin 250 prescription of the doctor to achieve high efficiency and avoid unwanted side effects.
Cases of antibiotic overdose Amoxicillin often show no symptoms. Depending on the individual patient with unusual symptoms such as electrolyte imbalance will have appropriate treatment. During the use of Amoxicillin 250 with high doses, patients need to ensure adequate water supply and excretion through the urine to limit the possibility of Amoxicillin crystalluria.
5. Amoxicillin 250 . side effects
Undesirable effects of Amoxicillin 250 are more likely to occur in patients who are sensitive to penicillin or have a history of bronchial asthma, allergic rhinitis and urticaria.
Some common side effects of Amoxicillin 250 include stomatitis, glossitis, nausea, diarrhea, colitis, acute interstitial nephritis, decreased platelet count, leukocytosis, leukopenia and loss White blood cells.
Patients need to quickly stop the drug and inform the doctor about the unwanted effects encountered when using Amoxicillin 250.
6. Amoxicillin 250 . drug interactions
Interactions with Amoxicillin 250 may occur during use as follows:
Bacteriostatic antibiotics such as Chloramphenicol, Erythromycin, Sulfonamides or Tetracyclines can affect the effect of Amoxicillin 250 and other Penicillins. Probenecid may decrease renal tubular secretion of Amoxicillin, leading to increased serum Amoxicillin concentrations or toxicity. Therefore, caution should be exercised when combining Amoxicillin 250 with Probenecid. Do not combine Amoxicillin 250 with Allopurinol, because it increases the risk of skin allergies. The antihypertensive drug Nifedipine may increase the absorption of Amoxicillin 250. To avoid drug interactions, patients need to inform their doctors about the drugs, herbs, and supplements they are using so that the doctor can consider and adjust them accordingly.
7. Be careful when taking Amoxicillin 250
Caution should be taken when using Amoxicillin 250 in the following cases:
In case of allergic manifestations, treatment with Amoxicillin 250 should be discontinued and appropriate alternative therapies should be sought. Amoxicillin 250 should be avoided when patients with infectious mononucleosis are suspected. Note that during treatment with Amoxicillin 250, there is a possibility of superinfection with fungi and resistant strains of bacteria. Patients with renal impairment require an adjustment in the dose of Amoxicillin 250. Pregnancy: The safety of Amoxicillin 250 during pregnancy has not been established. Therefore, only use Amoxicillin 250 when absolutely necessary. Lactation: Since Amoxicillin is excreted in human milk, caution should be exercised when Amoxicillin 250 is administered to this patient. Amoxicillin is a widely used penicillin antibiotic. This antibiotic is available in many different commercial products. The effect of Amoxicillin 250 is applied in the treatment of infectious diseases caused by strains that are still susceptible to Amoxicillin. To ensure effective use, patients need to carefully read the manufacturer's instructions for use and follow the doctor's instructions on dosage and usage.
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