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Amondys 45 is used in the treatment of Duchenne muscular dystrophy in both adults and children. The use of medication helps relieve the symptoms of the disease and helps slow the progression of complications.
1. Uses of Amondys 45
Amondys 45 has the main active ingredient casimersen. Amondys 45 is an FDA-approved medication and is used to treat Duchenne muscular dystrophy in adults and children with certain genetic mutations.
Duchenne dystrophy is an X-linked recessive genetic disease that causes a decrease in dystrophin, a protein in muscle cell membranes. This condition causes the patient to develop significant, progressive muscle weakness that can cause severe disability, including mobility difficulties, frequent falls, dilated cardiomyopathy, and early death from respiratory failure. steam.
Casimersen is engineered to bind to exon 45 located on the pre-mRNA of the dystrophin gene leading to removal of this exon during mRNA generation processing. Removing Exon 45 allows the body to still produce a shortened, but truncated, dystrophin protein that still functions.
2. How to use Amondys 45
2.1. How to take Before taking this medicine you will have blood tests done to make sure you do not have any medical conditions that could prevent the safe use of Amondys 45.
Amondys 45 is formulated as an intravenous infusion. You will have an intravenous infusion, usually once a week, by a healthcare provider. Amondys 45 must be infused slowly, and the infusion can take 35 to 60 minutes. During the use of the drug, you will be assessed for kidney function.
2.2. Dosage The dosage of Amondys 45 is based on body weight. Dosage requirements may change if you gain or lose weight. This will be done by your doctor to determine the right dose.
If you forget to take your medicine as directed, call your doctor for instructions on using Amondys 45 instead of the missed dose.
3. Possible side effects when using Amondys 45
When you take Amondys 45 the following side effects may occur:
Some very serious side effects may occur. You need emergency medical help if you have signs of an allergic reaction. reactions such as: Rash, itching, rash, blistering or peeling of the skin, fever, trouble breathing, swelling of the face, lips, tongue or throat. Serious side effects you may experience include: Pink, brown, or red urine; foamy urine; or swelling in the face, hands, feet, or abdomen. You should call your doctor right away if you have these symptoms. Common side effects may include: Headache, fever, joint pain, cough, cold symptoms such as stuffy nose, sneezing, sore throat. You may experience other side effects while taking this medicine, so it is important to tell your doctor about any side effects if you experience them.
4. Some notes when using Amondys 45
Do not use the drug if you have a history of allergy to the drug or any of its ingredients, severe kidney disease, pregnant and lactating women. Before taking the drug, you need to inform your doctor about your medical history, history of allergies. Other drugs may affect Amondys 45, including prescription and over-the-counter medicines, vitamins, and even herbal products. You need to tell your doctor about all of your current medications and any medications you start or have recently stopped using. Should be used strictly according to the doctor's instructions, in the process of using, if you gain or lose weight, you should talk to your doctor to adjust the appropriate dose. If you have any questions, you should consult your doctor directly.
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