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AmoDHG 500 is an oral antibiotic with a broad spectrum of action against most gram-positive and gram-negative bacteria. The drug is used under the prescription of a doctor, for safe and effective use of the drug, please refer to the information about the drug through the article below.
1. What is AmoDHG 500?
AmoDHG 500 has the main content of Amoxicillin (as Amoxicillin trihydrate) 500mg. The drug is prepared in the form of hard capsules (silver green - silver purple brown).
Amoxicillin is a beta lactam antibiotic, this is an aminopenicillin, stable in acid medium, has a broader spectrum of action than benzylpenicillin, especially has additional effects against gram-negative bacilli. Similar to other beta-lactam antibiotics, amoxicillin also has a bactericidal effect, by inhibiting the biosynthesis of mucopeptides of the bacterial cell wall.
Amoxicillin is active against most gram-positive and gram-negative bacteria such as: Streptococcus, non-penicillinase-producing staphylococci, H. influenzae, Diplococcus pneumoniae, N.gonorrhoeae, E.coli, and proteus mirabilis...
Amoxicillin is inactive against beta-lactamase-producing bacteria, especially methicillin-resistant staphylococci, all strains of Pseudomonas and most strains of Klebsiella and Enterobacter. Because the drug is inactivated by the enzyme beta-lactamase secreted by bacteria. Therefore, to increase the effectiveness of antibiotics, in some preparations people often combine with clavulanic acid to avoid the effect of this enzyme and expand the spectrum of action.
2. Indications and contraindications of AmoDHG 500
2.1.Indications AmoDHG 500 is indicated for use in a number of infections caused by susceptible bacteria in the following locations:
Upper respiratory tract, ear infections including: tonsillitis, nasopharyngitis , sinusitis , otitis media; Lower respiratory tract, as in acute bronchitis and chronic bronchitis, lobar pneumonia and bronchopneumonia; Gastrointestinal tract: such as fever caused by typhoid bacteria; Uncomplicated urogenital tract: As in urethritis, cystitis, gonorrhea, miscarriage, there is a risk of infection or obstetric infection. Infections such as sepsis, endocarditis, and meningitis caused by bacteria sensitive to amoxicillin should be treated initially with high-dose parenteral therapy and often in combination with another antibiotic. In this case, antibiotics should be used. In combination with other antibiotics and PPIs in the treatment of gastric ulcers caused by Helicobacter pylori. Endocarditis Prophylaxis: Amoxicillin can be used to prevent bacteremia that can cause the development of endocarditis. 2.2.Contraindications History of hypersensitivity to beta-lactam antibiotics (penicillins, cephalosporins). Patients with hypersensitivity to any ingredient of the drug.
3. Dosage and how to use AmoDHG 500
3.1.How to use AmoDHG 500 is used orally, due to its antacid properties, it can be better absorbed than Oral Ampicillin. Patients can drink at any time, food almost does not reduce drug absorption, but to ensure the best effect, you should drink before eating.
3.2. Dosage Adults and children over 40kg: If there is normal kidney function, take 500mg / time and 2 times / day for mild infections. Use 500mg / time and 3 times / day for severe infections. For gonorrhea take a single dose of 3g. Children under 40kg: Use at a dose of 20-50mg/kg/day, divided into 2 to 3 times. Amoxicillin oral solution should be given to children under 6 months of age. Renal impairment: Need to adjust dose according to creatinine clearance:
Creatinine clearance: Over 30ml/min, no dose adjustment is required. Creatinine clearance: From 10 to 30ml/min, use up to 500 ng, twice a day. Creatinine clearance less than 10 ml/min administered at a dose of 500 mg/24 h.
4. Side effects of AmoDHG 500
Possible but uncommon or rare side effects include:
Rare hypersensitivity reactions: Skin rash, pruritus, urticaria; erythema multiforme and Stevens-Johnson syndrome; toxic epidermal necrolysis, exfoliative dermatitis, and acute generalized pustular pustulosis (AGEP). Angioedema (Quincke's edema), anaphylactic reactions, serum sickness and hypersensitivity vasculitis; interstitial nephritis. If one of the above disorders occurs, you should not continue to take the drug and immediately go to a medical facility for treatment. Gastrointestinal side effects: Nausea, vomiting and diarrhea; superinfection causing intestinal candidiasis; antibiotic-associated colitis (including pseudomembranous colitis and hemorrhagic colitis). Hepatic effects: As with other beta-lactam antibiotics, hepatitis and cholestatic jaundice may occur. Transient leukopenia, transient thrombocytopenia, can cause hemolytic anemia; prolongs bleeding time and prothombin time. Hyperactivity, dizziness, may cause convulsions. Convulsions may occur in patients with renal impairment or in those taking high doses of the drug. When using AmoDHG 500, if the patient has any abnormal signs, it is necessary to notify or re-examine for advice.
5. Notes when using AmoDHG 500
Inform the doctor about the history of allergies and medical conditions encountered. Serious, sometimes fatal, hypersensitivity reactions have been reported in patients receiving beta-lactam antibiotics. If an allergic reaction occurs, Amoxicillin should be discontinued and appropriate alternative therapy instituted. Amoxicillin should be avoided if infectious mononucleosis is suspected. Prothrombin time prolongation has been reported, although very rarely, in patients receiving amoxicillin, so close monitoring is required when patients are treated with anticoagulants. When patients take drugs in high doses, kidney function must be carefully monitored, through the amount of urine. Pregnant women: The drug can be used by pregnant women, but consult your doctor before use. Lactation: Amoxicillin can be used during breastfeeding, but because the drug is excreted in breast milk, it should be used with extreme caution; Drug interactions:
Probenecid reduces the renal tubular secretion of amoxycillin. Concomitant use of AmoDHG 500 with amoxycillin may increase and prolong blood levels of amoxycillin. Your doctor may consider and consider changing your dose. Amoxicillin may decrease the effectiveness of oral contraceptives. Nifedipine, when co-administered, increases the absorption of amoxicillin. Taking allopurinol with amoxicillin increases the likelihood of amoxicillin causing a rash. There may be antagonism between amoxicillin and bacteriostatic agents such as chloramphenicol, tetracycline. Storage: Store in a tightly closed container at a temperature of 15-30 degrees Celsius. Keep the medicine out of reach of children and pets.
AmoDHG 500 is indicated for the treatment of infections caused by susceptible bacteria and is used under the direction and prescription of a doctor. Patients do not arbitrarily use drugs to avoid unwanted side effects affecting health.
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