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Aminomux drug has the main ingredient Pamidronate disodium, commonly used in the treatment of malignant hypercalcemia and bone diseases such as multiple myeloma, Paget's bone,... Let's learn about the use of Aminomux in article below.1. What is Aminomux?
Aminomux is manufactured by Cardinal Health Company - USA and is circulated on the market with registration number VN-3484-07. Aminomux is a prescription drug, classified in the group of analgesics, antipyretics, non-steroidal anti-inflammatory drugs, drugs for the treatment of Gout and osteoarthritis. The main active ingredient of Aminomux is Pamidronate disodium.
Dosage form: Capsules, each containing 100mg of Pamidronate disodium and other excipients of the manufacturer.
Packing form: Blister of 15 tablets, each box includes 2 blisters and drug instruction sheet.
2. Uses of Aminomux
Pharmacodynamics:
Pamidronate disodium has the ability to inhibit bone resorption caused by osteoclasts. In vitro, Pamidronate disodium strongly binds to hydroxyapatite crystals and inhibits their formation and dissolution. In vivo, the inhibition of osteoclastogenesis by osteoclasts is at least partly due to the drug's binding to bone minerals. Pamidronate blocks the penetration of osteoclast precursors to bone and prevents them from converting into osteoclasts. However, the binding of bisphosphonates to bone is considered to be the main mechanism by which the drug has direct local action against bone resorption. In addition, Pamidronate has an inhibitory effect on hypercalcemia due to tumor pathology, which is noted by a decrease in blood calcium and phosphate, and a decrease in urinary excretion of calcium, phosphate and hydroxyproline. In clinical trials in patients with multiple myeloma or with metastatic bone cancer, pamidronate was effective in preventing and delaying complications (fractures, hypercalcemia, radiation therapy, spinal cord compression). life, bone surgery) and bone pain relief. Pharmacokinetics:
Absorption: Pamidronate disodium is completely absorbed following intravenous infusion. Distribution: The binding rate of Pamidronate disodium to plasma proteins is approximately 54%. Peak plasma concentrations occur 1 hour after the 60 mg infusion. Elimination: Pamidronate disodium is virtually not eliminated by biotransformation.
3. Indications and contraindications of Aminomux
Aminomux is usually indicated in the following cases:
Malignant hypercalcemia. Paget's disease of bone. Bone cancer metastasis from breast cancer. Bone loss due to multiple myeloma. Contraindications: Absolutely do not use Aminomux for cases of hypersensitivity to any ingredient of the drug.
4. Dosage and how to use Aminomux
Aminomux is a prescription drug, so patients only use this drug when prescribed by a doctor and must adhere to the treatment schedule. To ensure safety, do not arbitrarily stop the drug, change the dose or route of administration. In addition, Aminomux should not be shared with others or given to others to use even if they have the same diagnosis.Dosage: It is necessary to monitor and adjust the dose of Aminomux according to the patient's age, comorbidities and current condition.
Recommended dose in the treatment of malignant hypercalcemia: A single dose of 60-90 mg/time, infusion lasting over 2 hours. In patients who respond to the drug, the initial dose can be resumed at least 7 days after the first dose. Recommended dose for treatment of bone Paget: 30mg/time/day infusion over 4 hours, continuously for 3 days. The recommended dose for the treatment of bone damage due to multiple myeloma, metastatic bone cancer from breast cancer: 90mg/time/month, infusion lasts for 4 hours. Usage: The component Pamidronate disodium in Aminomux will combine with divalent cations, so it should not be mixed with calcium-containing intravenous fluids.
How to handle when missed dose of Aminomux?
Aminomux is administered intravenously at a medical facility by medical staff. There is no daily dosing schedule. How to deal with Aminomux overdose?
When the patient shows signs of overdose, it is necessary to quickly notify the medical staff for timely treatment.
5. Undesirable effects
In addition to the therapeutic effect, Aminomux may cause some unwanted effects during use. However, these symptoms are usually mild and transient. The most common undesirable effects are: Asymptomatic hypocalcemia and fever,...
Common systemic symptoms are fever, flu-like symptoms, fatigue, chills, hot flushes, Symptoms Symptoms on organ systems: Musculoskeletal pain, systemic fatigue, digestive disorders, gastritis, headache, anemia, leukopenia, hypotension, hypertension, left ventricular failure, renal failure acute, conjunctivitis, episcleritis,... This is not a complete list of Aminomux undesirable effects. Patients may experience symptoms that have not been listed, studied, or reported. If you have any unusual symptoms while taking Aminomux, contact your healthcare provider immediately.
6. Drug interactions
The combination of drugs in treatment sometimes causes competition or synergies between the ingredients in the drug. In addition, certain foods and diseases can affect the absorption and effectiveness of the drug. Therefore, in order to be prescribed Aminomux safely, patients need to inform their doctor about the medicines they are taking, including prescription and over-the-counter medicines, dietary supplements, herbal products and other medicines. existing medical conditions (cancer, immunodeficiency, diabetes),... At the same time, discuss with your doctor some foods that should be avoided while taking Aminomux (especially tobacco, alcohol, fermented foods, etc.).
Drugs that can interact with Aminomux:
Potentially nephrotoxic drugs such as aminoside antibiotics, 1st generation cephalosporins, amphotericin B,... Thalidomide.
7. Some notes when using Aminomux
Use of Aminomux in pregnancy: Aminomux is toxic to the embryo and fetus, so do not use Aminomux during pregnancy. Use of Aminomux during lactation: Do not use Aminomux during this period. If use is mandatory, breast-feeding should be discontinued. Use caution when using Aminomux for patients undergoing radiation treatment, thyroid surgery, epilepsy, liver and kidney disease,... Need to check teeth and treat dental problems if any before use. Aminomux because it can cause serious problems with your jaw, especially in people who have surgery or dental treatment.
8. Preservation of drugs
Store Aminomux in the original manufacturer's packaging, in a cool, clean place away from direct sunlight. Keep Aminomux out of reach of children as well as pets, avoid them not knowing how to chew can cause serious unwanted effects. Aminomux has a shelf life of 36 months, do not use expired medicine or show signs of change in color, properties, taste, no labels. Do not throw Aminomux down the toilet or plumbing unless told to do so.
