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Amapirid medicine 4mg is a diabetes drug, belongs to the group of Sulfonylureas. The active ingredient is Glimepiride. What are the uses of Amapiride? Refer to the article below for more useful information.
1. Uses of Amapiride
Amapirid medicine 4mg is effective in the treatment of non-insulin dependent diabetes mellitus type 2 in adults. It is used when blood glucose levels cannot be controlled with diet, exercise, and weight loss alone. In addition, thanks to the ingredient Glimepiride, Amapirid 4mg can be used in combination with metformin or with glitazone or with insulin.
On the other hand, the drug is not indicated for prescription in the following cases:
Insulin-dependent diabetes Patients with renal failure, severe liver failure Diabetic ketoacidosis Hypersensitivity to the drug's ingredients, to other sulfonylureas Women pregnant or planning to become pregnant Women who are breastfeeding Pre-coma or coma due to diabetes.
2. Dosage and usage of Amapirid 4mg
2.1. Dosage The following is the recommended dose for each patient:
Start with 1mg x 1 time/day. Dosage varies according to the clinical symptoms of the patient.
Usual dose in patients with well controlled blood sugar: 1-4mg x 1 time/day. Daily doses above 6mg are only effective in some patients
However, in some cases, the doctor will adjust the dose, specifically:
As insulin sensitivity improves as the disease is under control, The need for glimepiride may be reduced with treatment over a period of time. To avoid hypoglycaemia, care should be taken to reduce the dose or discontinue the drug at the right time. The patient's weight and activities change. Factors that may increase sensitivity to hypoglycemia or hyperglycemia. It can also be used in combination with other non-beta-cell-directed oral antidiabetic agents. 2.2. How to take Amapirid 4mg is taken orally. The patient will be instructed to take the drug once a day, before or right in the morning with a lot of food or before the first main meal of the day.
2.3. In the process of using the drug, the patient may encounter an overdose. Some of the signs of this condition are: headache, fatigue, shivering, sweating, cold skin, anxiety, fast heart rate, low blood pressure, nervousness, restlessness, chest tightness, arrhythmia. heart, hunger pangs, nausea, vomiting, drowsiness, decreased concentration, decreased flexibility,... These symptoms can appear up to 1 day from the time of taking the drug.
When overdose, the patient should be taken to the hospital for timely treatment:
If the case is mild, the patient is prescribed to drink glucose or sugar 20-30 g mixed in a glass of water and blood glucose monitoring. Give once every 15 minutes until blood glucose returns to normal limits.
If the case of a severe overdose, the patient is comatose or unable to drink, the doctor will prescribe 50 ml of a 50% glucose solution intravenously. After that, a slow intravenous infusion of 10-20% glucose solution is required to gradually raise the blood glucose to the normal range. Blood glucose should be continuously monitored for up to 24-48 hours because recurrent hypoglycaemia is likely to occur. If severe, 1 mg glucagon may be administered subcutaneously or intramuscularly. If too much glimepiride is taken, gastric lavage and activated charcoal should be given.
In order for the drug to be effective in treating the disease, the patient needs to follow the instructions on the dose and how to use the drug from the doctor, avoiding the case of overdose or missed dose.
3. Amapiride side effects
Due to many reasons, people with diabetes may experience some unwanted side effects such as headache, digestive disorders, diarrhea, sensory disturbances, increased liver enzymes, decreased liver function, etc. Hemolytic anemia, red blood cells, leukopenia...
The above are not all the side effects that patients taking Amapirid encounter. Therefore, if you experience any side effects suspected of using the drug, the patient should stop taking the drug and notify the doctor.
4. Amapiride drug interactions
Drug interactions can reduce the effectiveness of treatment drugs or cause unwanted side effects. Here are some drugs that can interact with Amapiride that you need to avoid:
Insulin, oral diabetes medicine, chloramphenicol, coumarin derivatives, MAOIs, miconazole, phenylbutazol, Acetazolamide -blocker, diuretics, barbiturates, phenytoin , glucagons H2 antihistamines, clonidine, reserpine, alcohol Glimepiride
5. Be careful when taking Amapiride 4mg
Before prescribing, the doctor will carefully explain to the patient how to use the drug properly, such as complying with the dosage, following a scientific diet, and exercising regularly. The doctor will instruct the patient on how to manage the complications of hypoglycemia due to the glimepiride component, especially patients with poor nutrition, adrenal insufficiency, liver failure, and hypopituitarism who are prone to hypoglycemia. Patients who are stable on glimepiride regimen may become uncontrollable under stress, trauma, surgery, infection, and high fever. At that time, insulin should be used in combination with Glimepiride or insulin alone instead of Glimepiride. Patients may be advised not to operate machinery or drive a vehicle at the start of treatment because the drug may cause temporary visual disturbances due to changes in blood glucose levels. Patients should not drink alcohol during treatment with glimepiride because this can reduce the effectiveness of the drug. Check your blood sugar and urine sugar often, especially during the first week you start taking the medicine. Patients must absolutely not skip meals, fast after taking the drug. In case of missed dose, do not take a higher dose, it will cause an overdose, negatively affecting the patient's health. If the patient needs surgery or has an infection, high fever, difficulty eating, loss of appetite or is used in combination with other drugs such as anti-inflammatory drugs, -blocker, birth control pills, etc., it is necessary to notify the doctor. doctor. Always store the medicine under normal temperature conditions, away from direct sunlight, away from moisture. Thus, the quality and effectiveness of Amapirid will be guaranteed. The above article has helped readers answer questions about the use of Amapirid 4mg. Hopefully, it will help readers use the drug safely and promote its maximum effectiveness. In case. Long-term use of the drug, the condition is not improved, the patient should notify the doctor for more thorough advice.
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