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Anthelmintic drug Alxac Tab is indicated in the treatment of intestinal worms, liver flukes, tapeworms and tissue larvae. To ensure the effectiveness of use, users need to carefully read the instructions and consult a doctor, professional pharmacist.
What is Alxac Tab?
Alxac Tab is a broad-spectrum oral antihelminthic drug with the main active ingredient being Albendazol. The drug is prepared in the form of film-coated tablets with a strength of 400mg. Albendazol is a benzimidazol carbamate derivative, with a broad spectrum of activity against intestinal worms and migratory muscle and skin larvae; tapeworms and tissue tapeworm larvae.
At present, the mechanism of action of Albendazole is not fully known. The drug has a strong, specific affinity for binding to the free beta-tubulin protein in the parasite's cells, thereby inhibiting the polymerization of cytoplasmic microtubules, which are essential organelles for cell activity. parasites. Besides, the drug also inhibits glucose absorption of parasites at larval and adult stages, depleting glycogen, leading to parasites immobilization and death.
Indications and contraindications of the drug Alxac Tab
2.1. Indications for Alxac Tab
Alxac Tab is indicated in the following cases:
larval disease of the nervous system. Cystic disease in the liver, lungs and peritoneum before surgery or when surgery is not possible. Infection with one or more types of intestinal parasites such as roundworms, whipworms, whipworms, strongyloides, pinworms, and filariasis. Skin or visceral migration of larvae caused by Toxocara canis or T.cati. Disease caused by Giardia. Liver fluke disease 2.2.Contraindications
People who are allergic or hypersensitive to Albendazol or Benzimidazol compounds or certain components of the drug. Pregnant women. History of bone marrow toxicity.
How to take Alxac Tab
Alxac Tab tablets can be chewed, swallowed or crushed and mixed with food. Accordingly, patients do not need to fast before taking the drug.
Dosage of Alxac Tab specifically as follows:
Tuberculosis in nervous tissue
Adults and children from 6 years of age or older or weighing >= 60 kg: 400 mg/time x 2 times/day , taken with food for 8-30 days. If weight < 60 kg: 15 mg/kg/day (not to exceed 800 mg/day), divided into 2 times/day, taken with food for 8-30 days. Currently, there is no exact dose for children under 6 years of age.
Canine cystic disease
Dosage is the same as above but a course of treatment lasts 28 days, then repeated after a 14-day break. Drug treatment in 3 consecutive courses.
Roundworms, hookworms, whipworms, pinworms
Adults and children 2 years of age and older: 400 mg/time x 1 single dose/day. Repeat after 3 weeks if needed. Children < 2 years: single dose of 200 mg/dose for 1 day. Repeat after 3 weeks if needed. Strongyloidiasis
Adults and children 2 years of age and older: Use 400 mg/time/day orally for 3 days. Repeat after 3 weeks if needed. Children under 2 years old: 200 mg/time/day x 3 days. Repeat after 3 weeks if needed. Capillaria worm
Adults and children: 200 mg/time x 2 times/day, orally for 10 days Skin migrating larvae
Adults: 400 mg/time/day, orally for 3 days. If necessary, the treatment time can be increased by 5-7 days without worrying about being affected by side effects. Children: 5 mg/kg/day, used for 5 days Small fascioliasis
Children and adults: 10 mg/kg/day, used for 7 days Toxocarca infection (internal migration larvae) )
Dosage 400 mg/time x 2 times/day for 5 days, in both adults and children.
4. Some notes when using anti-helminth drugs
During the use of Alxac Tab, patients should note:
Identify the right cause to use the drug effectively. Most antihelminthic drugs are contraindicated for pregnant women, patients with cirrhosis of the liver, severe stomach ulcers. During the treatment of helminths, the patient needs to take the drug again every 2-3 weeks because the first dose only kills the adults, while the eggs and larvae do not. For the treatment of strongyloidiasis, indiscriminate use of immunosuppressive drugs such as corticosteroids can cause strongyloidiasis to flare up. It is necessary to screen to see if the patient has strongyloidiasis or not before using corticosteroids.
5. Undesirable effects when using Alxac Tab
Treatment for a short period of no more than 3 days may cause gastrointestinal discomfort (such as epigastric pain, diarrhea) and headache. In the case of high doses and long-term use, such as in the treatment of Echinococcus cyst or swine flu with brain damage, undesirable effects are more common and more severe. Usually, side effects are not too serious and go away on their own without treatment. Discontinue use in case of leukopenia (0.7%) or liver abnormalities (3.8% in cystic disease). Undesirable effects when using Alxac Tab may occur such as fever, headache, dizziness, increased intracranial pressure, increased liver enzymes, abdominal pain, nausea, vomiting. Less common side effects include allergic reactions, leukopenia, skin rash, urticaria and acute renal failure.
Precautions while using Alxac Tab
Before treating cysticercosis in the brain, the patient should have an eye exam to rule out retinal damage.
Albendazole is extensively metabolised in the liver. Cirrhotic patients have a reduced rate of hepatic drug clearance, which increases drug accumulation and increases undesirable effects of Albendazole. Albendazol should be used with caution in patients with impaired liver function. Monitor liver function and blood count twice during each treatment cycle and during long-term and high-dose Albendazol treatment in cysticercosis or cysticercosis.
The possibility of pregnancy should be excluded before 1 month before starting high-dose and long-term Albendazol therapy (use of contraception is necessary during and 1 month after taking the drug).
Pregnancy: Animal studies have shown that Albendazole is teratogenic. Currently, the drug has not been studied in pregnant women, so its use is contraindicated in this population. Women of childbearing age should take Albendazol within the first 7 days of their menstrual cycle. When starting to use the drug, contraception should be used during and for 1 month after stopping the drug. Lactation: It is not known how much Albendazole is excreted in human milk. Use caution when using Alxac Tab in lactating women.
Alxac Tab drug interactions
Concomitant administration of Alxac Tab with dexamethasone increases plasma concentrations of the active substance Albendazol sulfoxide by more than approximately 50%. Praziquantel administered at a dose of 40 mg/kg increased the mean plasma concentration and AUC of Albendazol sulfoxide by approximately 50% compared with albendazole alone (400 mg). Cimetidine: Albendazol sulfoxid in bile and in cyst fluid increased concentrations approximately 2 times in patients with cysts when used in combination with Cimetidine (10 mg/kg/day). Alxac Tab is indicated in the treatment of intestinal worms, liver flukes, tapeworms and tissue larvae. To ensure effective use, users need to carefully read the instructions and consult a doctor, professional pharmacist.
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