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Alvofact is indicated for premature infants at high risk of respiratory distress syndrome (RDS). To ensure safety and effectiveness in using the drug, you need to follow the instructions of your doctor.
1. What is Alvofact?
Alvofact medicine contains the main ingredient is phospholipids isolated from bovine embryos. Each vial contains 50.76 to 60.00 mg of phospholipid fraction (powder) equivalent to an amount of 66 mol or 50 mg of total phospholipid as lyophilized powder. Excipients include: 1 syringe of 1.2ml containing sodium chloride, sodium hydrogen carbonate, water for injection.
The drug is prepared in the form of a powder and a solvent to make a suspension. Packing includes 1 vial of dry powder, 1 syringe containing 1.2ml solvent, 1 catheter and 1 connecting tube.
2. Indications and contraindications to the drug Alvofact
Indications for use of Alvofact drug in the following cases:
Prophylaxis of premature infants at risk of respiratory distress syndrome (RDS). Contraindications to Alvofact:
Hypersensitivity to the ingredients in the drug Alvofact. Precautions: The benefits and risks of Alvofact therapy for congenital infections in premature infants have not been established. The latter effect may be reduced if congenital pneumonia is suspected. Pulmonary function may also be impaired in the presence of hypoplasia of embryonic tissue (prolonged oligohydramnios due to gill rupture or congenital renal impairment).
3. Dosage and how to use Alvofact
Dosage of Alvofact:
It is recommended to use a single dose of 1.2ml/kg body weight (equivalent to 50mg total phospholipids/kg body weight), used in the hour postpartum. Depending on respiratory needs, after the first dose, the next 3 similar doses can be used. The total dose administered should not exceed 4 doses (equivalent to 200 mg total phospholipids/kg body weight) within the first 5 days postpartum. How to use Alvofact:
Give Alvofact a single dose of 1.2ml/kg body weight by rapid injection into the trachea through a catheter. Inject additional air to ensure that the drip is completed. During catheter removal the patient should be reinserted with an artificial ventilator. Overdose treatment:
There have been no reports of overdose cases with Alvofact. In the majority of cases where there is uncertainty about the cause of a drug overdose, it is recommended to aspirate as much fluid as possible if that is the way to reduce the clinical effect. Combined with the treatment of symptoms occur as needed.
5. Alvofact drug side effects
Alvofact may cause the following side effects:
Due to the amount of fluid, tracheal or bronchial obstruction may develop rapidly after taking Alvofact . This symptom can be treated by increasing the inspiratory pressure for 30 to 60 seconds. It is uncertain whether premature infants are sensitive to cattle embryonic proteins, but there is a condition that can cause hypersensitivity reactions, requiring usual emergency measures. Inform your doctor about any unwanted effects you may experience while using the drug.
6. Drug interactions
So far there have been no interactions related to the active ingredients in Alvofact. No adverse effects from the above drug therapy were observed after antenatal respiratory distress syndrome prophylaxis with Ambroxol infusion solution or maternal glucocorticoids.
7. Notes and storage of Alvofact
Precautions when taking Alvofact:
Preclinical studies demonstrate that granulocyte-protective cells (macrophages, leukocytes) phagocytize emulsified lipids. This process can be disrupted by taking Alvofact in case of pneumonia and/or infection. Alvofact should only be used when there are good means of ventilation and monitoring of premature infants with respiratory distress syndrome. There have been reports of isolated cases of tracheal tube obstruction due to sticky mucus. The origin and composition of this is unknown. Storage of Alvofact:
Do not store powder or solvent at temperatures above 30 degrees Celsius. Do not freeze powder, solvent or diluent mixture. The diluted suspension can be stored for 6 hours at 25°C or 24 hours at 2-8°C. In this case the vial and syringe should be gently shaken before use. The article has provided information about the drug Alvofact has the effect, dosage and note when using. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Alvofact exactly as directed by your doctor.
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