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Alembic Irbatal H has the main active ingredients Irbesartan and Hydroclothiazid. Alembic Irbatal H belongs to the group of drugs for cardiovascular disease. It is used in the treatment of primary hypertension in people whose disease is not controlled by irbesartan or hydroclothiazid alone.
1. What is Alembic Irbatal H?
The active ingredient Alembic Irbatal H is Irbesartan 150mg and Hydrochlorothiazide 12.5mg. Alembic Irbatal H belongs to the group of drugs for cardiovascular disease. Packaging is a box of 10 blisters, each blister contains 10 tablets. The dosage form of the drug is a film-coated tablet, suitable for oral use.Alembic Irbatal H is used in the treatment of primary hypertension in people whose disease is not controlled by irbesartan or hydroclothiazid alone.
2. What disease does Alembic Irbatal H treat?
Alembic Irbatal H is used in the treatment of primary hypertension in people whose disease cannot be controlled with Irbesartan or Hydrochlorothiazide alone.
3. Usage and dosage of Alembic Irbatal H
Patients need to use Alembic Irbatal H only once a day. Because Alembic Irbatal H is not affected by food, you can take it with or without food. Accordingly, the dosage adjustment of the treatment depends on the individual components of Irbesartan and Hydrochlorothiazide.
Note: Treatment doses higher than 300 mg Irbesartan/25 mg Hydrochlorothiazide once a day are not recommended. The combination of drugs with other antihypertensive drugs must be prescribed by the treating doctor.
4. Undesirable effects of the drug Alembic Irbatal H
4.1. Undesirable effects due to active ingredient Irbesartan Adverse effects caused by active ingredient Irbesartan are generally mild and transient.
Common unwanted effects when using Alembic Irbatal H include: darkening of the face, dizziness; headache and dose-related orthostatic hypotension; hypotension may occur in volume-depleted patients (e.g. when the patient is taking high-dose diuretics); renal failure and severe hypotension in the presence of bilateral renal artery stenosis.
4.2. Undesirable effects due to the active ingredient Hydrochlorothiazide Hydrochlorothiazide may cause excessive loss of potassium. This effect is dose dependent and may be reduced by low therapeutic doses (12.5 mg/day), the best therapeutic dose for lowering blood pressure while minimizing adverse reactions.
Common unwanted effects when using Alembic Irbatal H such as: feeling tired, dizzy, dizzy, headache; decreased blood potassium, increased uric acid in the blood, increased blood sugar index, increased blood lipids (at high therapeutic doses). Uncommon and rare adverse effects such as hyperuricemia may trigger a potential gout attack. Orthostatic hypotension may occur when Alembic Irbatal H is co-administered with alcohol, anesthetics and sedatives.
5. Drug interactions of Alembic Irbatal H
Some possible drug interactions when taking Alembic Irbatal H are as follows:
With other antihypertensives: The antihypertensive effect of Alembic Irbatal H may be increased when used with other antihypertensives. other hypertension. Drugs that affect potassium: The potassium-depleting effect of Hydrochlorothiazide is minimized by the potassium-sparing effect of Irbesartan. However, this effect of the active ingredient Hydrochlorothiazide on serum potassium is likely to occur when other drugs that cause potassium loss and hypokalemia are co-administered (e.g., potassium-sparing diuretics, laxatives, etc.). amphotericin, carbenoxolone, penicillin G sodium, salicylic acid derivatives). Drugs Affected by Disturbances in Serum Potassium: Periodic monitoring of serum potassium is recommended when Alembic Irbatal H is co-administered with medicinal products affected by disturbances in serum potassium. Lithium: Increased serum lithium concentrations and reversible increases in toxicity have been reported in combination with ACE inhibitors. In addition, the renal clearance of lithium will be reduced by thiazides. Therefore, the risk of lithium toxicity may be further increased with Alembic Irbatal H. Patients should be cautious when co-administering lithium with Alembic Irbatal H and careful monitoring of serum lithium levels.
6. Some notes when using Alembic Irbatal H
6.1. Contraindications of the drug Alembic Irbatal H People with hypersensitivity or hypersensitivity to any component of the drug Alembic Irbatal H or to a sulfonamide derivative (hydrochlorothiazide is a sulfonamide derivative). Women who are pregnant and those who are breastfeeding. Contraindications related to the active ingredient Hydrochlorothiazide: People with severe renal impairment with creatinine clearance < 30 ml/min; Inert hypokalemia, hypercalcemia; People with liver disease such as severe liver failure, biliary cirrhosis and cholestasis. 6.2. Notes and precautions when using Alembic Irbatal H Due to the active ingredient Irbesartan
Decrease in blood volume: Symptomatic hypotension may occur, especially after taking the first therapeutic dose. In individuals with hypovolaemia, such as salt and water loss caused by strong diuretics, dietary salt restriction, diarrhea or vomiting, these conditions should be corrected prior to initiating therapy with medicinal products. Contains the active ingredient Irbesartan. Renal artery stenosis: There is an increased risk of severe hypotension and renal failure for patients with bilateral renal artery stenosis or artery stenosis of one functional kidney being treated with drugs that act on the system. renin-angiotensin-aldosterone. Renal failure and kidney transplantation: When using irbesartan-containing preparations for people with renal failure, it is necessary to regularly check serum potassium and creatinine levels. Hyperkalemia: There may be an increase in blood potassium when using the active ingredient Irbesartan, especially in people with poor heart and kidney function. Avoid concomitant use of preparations containing the active ingredient Irbesartan with potassium-sparing diuretics. Mitral and aortic stenosis, hypertrophic obstructive cardiomyopathy: Particular caution should be exercised in those with existing mitral or aortic stenosis, or with obstructive hypertrophic cardiomyopathy. congestion. Patients with primary hyperaldosteronism: Irbesartan is not recommended. Active ingredient Hydrochlorothiazide
Because Alembic Irbatal H contains Hydrochlorothiazide, your doctor will prescribe periodic monitoring of serum and urine electrolytes, especially those who are taking corticosteroids, ACTH or digitalis, quinidine (risk torsades de pointes causing ventricular fibrillation). People with severe kidney failure: Increases blood urea nitrogen and may further impair kidney function. People with liver failure: prone to hepatic coma. People with gout will have a more severe course of the disease. Diabetes: Pay attention to adjusting the therapeutic dose of drugs (insulin, blood sugar-lowering drugs). The antihypertensive effect of the active ingredient hydrochlorothiazide is increased in postsympathomimetic subjects. Increased cholesterol and triglycerides in the blood. Be careful when using Alembic Irbatal H in the elderly, because it is easy to lose electrolyte balance. 6.3. Use of Alembic Irbatal H for pregnant and lactating women For pregnancy: Contraindicated using Alembic Irbatal H for pregnant women. In the first 3 months of pregnancy contraindicated due to caution. During the second or third trimester of pregnancy, the use of Alembic Irbatal H may affect the growth and development of the fetus or cause neonatal toxicity. For lactation: Alembic Irbatal H is contraindicated in women who are breast-feeding. Effects of the drug on the ability to drive and use machines: You need to be careful when using Alembic Irbatal H when driving or operating machinery. This is because the drug can cause dizziness and fatigue. Alembic Irbatal H has the active ingredients Irbesartan and Hydroclothiazid. Alembic Irbatal H belongs to the group of drugs for cardiovascular disease. It is used in the treatment of primary hypertension in people whose disease is not controlled by irbesartan or hydroclothiazid alone. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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