This is an automatically translated article.
Folic acid is known to be an important and necessary nutrient for metabolic processes in the body. In addition to dietary supplements, some cases of high risk of folic acid deficiency can use Aginfolix 5mg to supplement this nutrient.1. What is Aginfolix 5?
Aginfolix is a product of Agimexpharm Pharmaceutical Joint Stock Company, the main ingredient is Folic Acid with 5mg content. Aginfolix 5mg is classified as a nutritional supplement for the following cases of folic acid deficiency in megaloblastic anemia, large red blood cell size due to folate deficiency, used for pregnant women, folic acid supplementation in patients with chronic hemolytic anemia (such as thalassemia or sickle cell anemia) or those on hemodialysis. Folic acid in Aginfolix 5mg is a B vitamin. When put into the body, Aginfolix is reduced to tetrahydrofolate, a coenzyme that plays a role in many metabolic processes in the body, including biosynthesis. Nucleotide with a purine or pyrimidine nucleus. Therefore, folic acid supplementation may have an effect on DNA synthesis.
When vitamin C is present, folic acid is converted into leucovorin, which is necessary for the synthesis of DNA and RNA. In addition, folic acid is an important nutrient indispensable in the synthesis of nucleoprotein and normal red blood cell production. This explains why folic acid deficiency will lead to megaloblastic anemia similar to anemia caused by vitamin B12 deficiency.
Pharmacokinetic characteristics of the drug Aginfolix 5mg:
Aginfolix is rapidly released in the stomach, then absorbed mainly in the first small intestine. The amount of folic acid supplement in the normal daily diet is absorbed very quickly and distributed in most tissues in the body; After absorption, the drug Aginfolix 5mg will be stored mainly in the liver and can be actively concentrated in the cerebrospinal fluid; In terms of elimination, every day about 4-5 micrograms of folic acid passes out through the urine. At the same time, the more folic acid is added, the higher the amount of folic acid excreted in the urine; Aginfolix 5mg can cross the placenta and is present in breast milk. Aginfolix 5mg is made in the form of hard capsules, packed in boxes of 10 blisters x 10 tablets.
2. Uses of Aginfolix 5
Aginfolix 5 is indicated for additional treatment of Folic Acid for the following cases:
Folic acid deficiency in patients with megaloblastic anemia and macrocytic anemia due to folate deficiency; Pregnant women used to prevent neural tube defects in the fetus during the period from 4 weeks before pregnancy and maintain in the first 3 months of pregnancy; Folic acid deficiency in people with chronic hemolytic anemia such as thalassemia or sickle cell anemia; Supplement for patients on hemodialysis.
3. Dosage of the drug Aginfolix 5
Aginfolix 5mg drug is prepared for oral use with specific doses as follows:
Prevention and treatment of folic acid deficiency in people with megaloblastic anemia and macrocytic anemia due to folate deficiency: Take 1 daily Aginfolix 5mg tablets for a period of 4 months, malabsorption cases can be increased to 15mg (3 tablets) per day; Prophylaxis in pregnant women at risk of neural tube defects in the fetus: Take 1 tablet of Aginfolix 5mg daily, starting 4 weeks before pregnancy and maintaining until the end of the first 3 months of pregnancy; Thalassemia, sickle cell anemia and prevention in hemodialysis patients: Take 1 tablet of Aginfolix 5mg continuously every 1 or 7 days depending on nutrition and hemolysis rate.
4. Side effects of Aginfolix 5
When using Aginfolix 5, there is still a risk of some unwanted effects (ADRs). However, these effects are relatively rare (ADR < 1/1000) such as
Skin itching, rash or urticaria; Digestive disorders . Stop using Aginfolix 5mg and quickly inform the doctor about the unwanted effects that the patient experiences during the use of the drug.
5. Some notes when taking Aginfolix 5mg
Aginfolix 5mg product is not used (contraindicated) for people who have previously had a history of allergy to the ingredients contained in the drug.
Do not use Aginfolix 5mg alone or in combination with vitamin B12 supplements with insufficient doses to treat megaloblastic anemia without a definitive diagnosis. Multivitamin preparations may contain folic acid, which when used can be dangerous by masking the true extent of vitamin B12 deficiency in megaloblastic anemia caused by vitamin B12 deficiency.
Although Aginfolix 5mg can induce a hematopoietic response in people with megaloblastic anemia due to vitamin B12 deficiency, this case should not be supplemented with folic acid alone because of the risk of promoting spinal degeneration. semi-level.
Caution should be exercised when administering Aginfolix in people who may have folate-dependent tumors.
Aginfolix 5mg does not affect the ability to drive or use machines.
Folic acid supplementation for pregnant women is very necessary, especially in cases of epilepsy or malaria because treatment drugs can cause folic acid deficiency.
Folic acid can be excreted in breast milk, but nursing mothers can still use Aginfolix 5mg.
6. Aginfolix drug interactions
Co-administration of Aginfolix 5mg with sulphasalazine may reduce the absorption of folic acid; Aginfolix 5mg and oral contraceptives may interact, thereby reducing folic acid metabolism and may reduce folate and vitamin B12 to a certain extent; Drugs Aginfolix 5mg and drugs to treat seizures: If Aginfolix 5mg is used to supplement folate deficiency caused by anticonvulsants, the concentration of anticonvulsants in the blood may be reduced; The drug Aginfolix in combination with Cotrimoxazol may reduce the effect of folic acid in the treatment of megaloblastic anemia.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
