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Agicetam 400 has the main ingredient Piracetam, which belongs to the group of psychotropic drugs. The drug Agicetam 400 is commonly used in the treatment of nervous system disorders, ischemic stroke, alcoholism... Find out information about Agicetam 400 that will help patients improve the effectiveness of the treatment. treatment and prevention of drug-induced side effects.
1. What is Agicetam 400?
Agicetam 400 is made in the form of hard capsules, with the main ingredients including:
Active ingredients: Piracetam 400 mg. Excipients: Colloidal silicon dioxide, Sodium starch glycolate, Magnesium stearate just enough 1 hard capsule 400 mg. Active ingredient Piracetam is a cyclic derivative of Gamma Aminobutyric Acid (GABA), has the following mechanisms of action:
Increases activity in the brainstem region, which is involved in cognitive activities, consciousness, alertness, memory and memory. study. Acts on neurotransmitters such as Dopamine, Acetylcholine, Noradrenalin... thereby improving the metabolic environment to help nerve cells work well in learning or memory. Increases brain resistance to hypoxia, thereby protecting against metabolic disorders caused by cerebral ischemia. Increases oxygen-independent glucose utilization and mobilization, facilitating the Pentose pathway, while maintaining brain energy synthesis. Reduces platelet aggregation and helps stiffened red blood cells recover their ability to deform to pass through capillaries. Anti-vibration.
2. What are the effects of Agicetam 400?
Agicetam 400 is indicated for the treatment of the following cases:
Common symptoms in the elderly such as mental decline, poor concentration or lack of alertness, mood changes, poor attention to self , dementia due to cerebral infarction , behavioral disorders. Dizziness symptoms. The patient had an acute ischemic stroke. Treatment of patients with alcohol dependence. Treatment of sickle cell anemia. Support the treatment of myoclonic tremor caused by damage to the cerebral cortex.
3. Contraindications of Agicetam 400
Agicetam 400 is contraindicated in the following cases:
Hypersensitivity to any ingredient of Agicetam 400. History of allergy to antibiotics containing Piracetam. People with Huntington's disease. People with severe liver and kidney dysfunction.
4. Dosage and how to use Agicetam 400
Usual dose:
Take 30-160mg/kg/day x 2-3 times/day. Symptoms of neuropsychiatric disorders in the elderly:
Dose: Take 1-2 tablets (400-800mg)/time x 3 times/day. The maximum dose should not exceed 12 tablets/day. Alcoholic patients:
Attack dose: Take 12000mg/day. Maintenance dose: Take 4 tablets (1600mg)/time x 3 times/day. Consciousness decline after traumatic brain injury:
Attack dose: Oral 9000 - 12000mg/day. Maintenance dose: Take 2 tablets (800mg)/time x 3 times/day. Sickle cell anemia:
Dose: 160mg/kg/day x 4 times/day. Myoclonic tremor:
Initial dose: Take 6-9 tablets (2400-3600mg)/time x 2-3 times/day. Increase dose by 4800mg/day every 3 to 4 days. The maximum dose is 20000mg/day. Reduce dose after reaching the optimal dose, and reduce the dose of drugs used in combination with Agicetam 400. Patients with impaired renal function use a dose based on Creatinine clearance (CrCl) or blood creatinine levels:
Dose CrCl 60 - 40ml/min or blood creatinine level 1.25 - 1.7mg/ 100ml: Take 1⁄2 usual dose (Take 15 - 80mg/kg/day x 2-3 times/day). Dose of CrCl 40 - 20ml/min or blood creatinine level 1.7 - 3.0mg/ 100ml: Take 1⁄4 of the usual dose (Take 7.5-40mg/kg/day x 2-3 times/day).
5. Precautions when using Agicetam 400
Treatment with Agicetam 400 drug with high dose or long term, can cause side effects such as:
Common: Digestive disorders such as nausea, vomiting, abdominal pain, bloating, diarrhea. Nervous and systemic symptoms such as fatigue, restlessness, headache, insomnia, somnolence, excitability Uncommon: Neurological and systemic symptoms such as dizziness, tremor, sexual arousal. The drug should be stopped immediately when detecting the above undesirable symptoms after using Agicetam 400 or promptly notify the doctor and immediately go to the nearest medical facility for supportive treatment.
Notes on the use of Agicetam 400 in the following subjects:
Caution should be exercised when using Agicetam 400 in patients with renal failure, the dose should be reduced and renal function should be monitored regularly in this subject. Agicetam 400 should be used with caution in patients with a history of hemorrhagic stroke, peptic ulcer disease, and who are being treated with drugs that cause bleeding because Agicetam 400 causes coagulation disorders and increases the risk of bleeding. . Pregnancy: Studies have shown that Agicetam 400 can cross the placenta, causing harmful effects during pregnancy, so Agicetam 400 should not be used in this population. Lactation: There are currently some studies indicating that the active ingredient Piracetam in Agicetam 400 can be excreted in breast milk. Therefore, Agicetam 400 should not be used on this subject. Drivers or workers who operate machinery may experience symptoms such as dizziness, headache, drowsiness...after using Agicetam 400.
6. Agicetam 400 . drug interactions
Interactions with other drugs:
Using Agicetam 400 together with Warfarin can cause blood clotting disorders manifested by prolonged Prothrombin time. Concomitant use of Agicetam 400 with thyroid-containing medicinal products may cause sleep disturbance, confusion and excitability. The above is information about the ingredients, uses, doses and side effects when using Agicetam 400 medicine. In order to bring the best treatment results, patients and family members should carefully read the instructions for using Agicetam 400, strictly follow the instructions of the treating doctor.
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