This is an automatically translated article.
Agenerase belongs to the Amprenavir class of drugs that inhibit the protease of immunodeficiency virus. Some side effects can be dangerous if you take them the wrong way. The treating doctor will prescribe and guide specifically how to use as well as note to avoid when using Agenerase drug.1. What is Agenase?
The drug Agenerase combines several excipients into a 50 mg capsule. The capsule and the excipients that form the capsule are not therapeutically active. The composition of the capsule shell is made of soft gelatin, which is safe for patients to swallow. In 50 mg of the drug contains 36.3 IU of vitamin E.
The drug Agenerase binds to the protease that can stop the virus from attacking the body's immune system. Especially the viruses in the immature stage meet the drug Agenerase, which will limit the ability to infect or not infect.
2. Uses of the drug Agenase
According to the experimental analysis results, the drug Agenerase can fight the HIV virus. Lymphoblasts with acute or chronic viral infections will improve their function with the use of drugs. For each patient, the level of resistance to the virus is not the same, so it is difficult to give a general dose. One limitation is that the results were mainly in rats, with too few studies involving humans. The ability to inhibit against agents that weaken the immune system is still a speculation without really convincing evidence.
Although no confirmed ability to inhibit the virus that weakens the immune system has been published, this virus is quite sensitive to the drug Agenerase. When interacting with drugs, the virus under the lens was found to have the ability to change structure. Some argue that the virus that weakens the immune system has a complex genetic modification that limits the effectiveness of the drug. Some studies have shown that when viruses mutate they can reduce the inhibition brought by the drug Agenerase.
3. Dosage and how to use the drug Agenerase
3.1 How to take the medicine and the prescribed dose
Adults after taking the drug the body will quickly be absorbed and metabolized. A few subjects with the disease of the century participated in the treatment program with the drug Agenerase. Dosage for patients ranges from 150 to 1200 mg. They will use it twice a day for about 3-12 weeks and continuously monitor blood counts. Analysis of HIV patients after 3 weeks of using Agenerase at a dose of 300 - 1200 mg, there was an increase in plasma drug concentration. People infected with HIV after taking the drug, the concentration of the drug measured in the blood peaked after the first 1-2 hours.
If you are diagnosed with liver failure, use a single dose of 600 mg with the supervision of a doctor. The more severe the liver cirrhosis, the doctor will consider reducing the dose accordingly. Similar to patients with renal failure, this organ cannot excrete metabolites if the function is impaired.
Children between the ages of 4 and 12 should be considered for Agenerase. If injection to children, the single dose is 5 mg/kg or 20 mg/kg for capsules. Children under 4 years old should not use the drug because the body is still immature and there is a risk of toxicity from the excipients of the drug. Drug use is not influenced by factors such as gender or race.
3.2. Treatment of an overdose of Agenase
Currently, there is no treatment for patients with toxicity after using Agenerase. When overdosing, you need to quickly check and do tests to determine the level of toxicity. The patient may be considered for treatment with peritoneal dialysis or hemodialysis. After that, the doctor will monitor other reactions and manifestations of the patient's health to avoid dangerous reactions to health and life.
4. Statistical drug side effects
If you experience nausea, diarrhea or discomfort, tell your doctor. During the first 12 weeks of use, gastrointestinal reactions occur quite commonly. Some patients develop a skin rash after taking Agenerase. On average, after 10 days of taking the drug, a rash will appear in about 22% of patients. About 3% of patients who identify a skin rash will be asked to stop by their doctor for monitoring.
In experiments with mice, the drug Agenerase capsules caused cancer. with high dose 600 - 750 mg/kg will appear hepatocellular adenoma and carcinoma in mice. This experiment carried results on mice, so it needs to be carefully examined. It is not possible to guarantee that every reaction in a mouse will occur in a human body. But it is possible that the drug Agenerase is the cause of the chromosomal aberration of human lymphocytes.
5. Interactions of Agenerase Drugs Interactions can occur when you are sensitive to Agenerase drugs or drugs in the Sulfonamide group. When taking the drug, the liver is the organ of metabolism, so some patients will have an increase in SGOT (AST) and SGPT (ALT) in the total blood count analysis. If you are suffering from liver failure, you need to determine the extent of the disease so that your doctor can advise you to adjust the dose to avoid harm to the liver. You will take vitamin E supplements while taking Agenerase to avoid excess vitamin E causing anemia.
When you are treated with agenerase in combination with ritonavir, there will be an increase in triglyceride and cholesterol levels. To prevent this interaction from happening it is necessary to test for triglycerides. At the same time, you should reduce fat so as not to affect the body's absorption of the drug Agenerase.
Hormonal contraceptives are suspected to reduce levels of the drug Agenerase. If you are taking both hormonal birth control pills and Agenerase, tell your doctor. Contraceptives that limit hormonal effects will be preferred to reduce drug interactions. In addition, sedatives, herbal medicines, HMG Co-reductase inhibitors are also contraindicated to use with Agenerase.
6. How to use the drug Agenerase The drug Agenerase is used according to the doctor's prescription. Dosage will be based on the medical record of each treatment subject. If you miss a dose more than 4 hours, skip it and take the next dose to maintain your treatment. However, if the time to forget the dose is not long, the dose can be guaranteed. If the medicine does not work or if you have unusual symptoms, tell your doctor. You need to follow the doctor's instructions to avoid changing the dose or stopping taking the medicine on your own.
7. Several other studies on the drug Agenerase The interaction of the drug Agenerase with hormonal contraceptives prompted researchers to continue to analyze fertility and the effect of the drug on the fetus. Fertility tests were conducted in rats and showed no effect on fertility. However, mice tested after pregnancy had an increased risk of miscarriage or offspring with altered bone structure.
Pregnant women with HIV will not breastfeed to reduce HIV transmission to the newborn. They may be considered for medication because they are not breastfeeding. Some extended studies will examine the drug's metabolism into the mammary glands to assess the effect on nursing women. Children over 4 years old can take the drug if the doctor prescribes it.
The side effects of the drug Agenerase listed above are not all. Some of the more dangerous side effects can happen when you take your medicine without a prescription from your doctor. Always tell your doctor or go to the hospital to get the best treatment support.
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